Arginine, a semi-essential amino acid, has been studied extensively for many years as a protective agent against cardiovascular disease. It stimulates production of nitric oxide (NO), a substance that helps relax the smooth muscle cells in blood vessels and thus promotes dilation of arterial vessels.
Silicon is recognised as playing a key role in protecting connective tissue. Concentrated inside the arteries, it reduces permeability of the tissue surrounding the artery wall, boosts and improves the flexibility of arterial walls and thus increases blood flow.
By combining arginine and silicon in a single molecule, arginine-silicate-inositol, this new patented form offers synergistic effects designed to promote increased NO production, which helps improve dilation of vessels and enhances blood flow.
Preclinical animal studies and scientific experiments have confirmed that:
• it is fully absorbed;
• it reaches the blood just 30 minutes after ingestion and remains effective for up to three hours thereafter;
• it produces a significant and long-lasting increase in NO levels, unlike standard arginine.
Research has examined the effects of taking arginine-silicate-inositol compared with arginine HCI, following administration of bradykinin, a standard vasodilator used as a control.
It showed that arginine-silicate-inositol:
• increased blood flow two-fold compared with arginine HCI, and four-fold compared with controls;
• produced five times greater relaxation of blood vessels than arginine HCI;
• increased absorption of silicon by more than 200% compared with that from dietary intake.
Clinical studies have confirmed the safety of this substance which now has recognised GRAS status (Generally Recognized As Safe).
In clinical studies, male volunteers aged 18-40 were given 1500mg/day of arginine-silicate-inositol for 14 days. When researchers analysed blood proteins known for their direct relation with vessel dilation and cardiovascular health, they found positive results on eight of the most important protein markers, and in particular, a 70% reduction in cystatin-C (higher levels being associated with increased cardiovascular risk) and a 32% increase in kallistatin (a potent vasodilator).
Other arginine supplements are also available from our catalogue: , the specific form or the arginine precursor .
Given that a simple initial single dose of arginine-silicate-inositol is enough to increase plasma concentrations of arginine and silicate, as well as to accelerate nitric oxide concentration, there is no doubt that this new molecule is ideal for anyone wishing to maintain healthy artery walls as well as for athletes looking to support muscle growth and recovery by improving blood flow before and after exercise.
Adults. Take one tablet once or twice a day on an empty stomach.
Each tablet contains 750 mg de Nitrosigine®