Sulbutiamine is a synthetic derivative of thiamine (vitamin B1). As a dimer combining two modified thiamine molecules, it readily crosses the blood–brain barrier thus increasing levels of thiamine and thiamine phosphate esters in the brain. Sulbutiamine was developed in Japan by Taisho Pharmaceutical in 1965.
Sulbutiamine is a psychostimulant, the anti-asthenic and energising effects of which are the result of modification of the thiamine ring, formation of a disulfide bridge, creation of a lipophilic ester and opening of the thiazole cycle. The resulting new lipophilic compound is therefore responsible for its valuable properties.
Sulbutiamine's main benefit lies in its ability to combat asthenia by selectively targeting the areas involved in the condition. Asthenia is essentially a form of chronic fatigue that is cerebral rather than neuromuscular in origin. In trials conducted on this compound, in which sulbutiamine was given for 15 days to patients suffering from craniocerebral trauma or post-infectious chronic fatigue, 916 of the 1772 patients involved in the trial experienced complete recovery.
Following this positive result, scientists expanded their research to focus on other potential areas of activity:
|Daily dose: 2 capsules
Number of doses per pack: 50
|Amount per dose|
|Other ingredients: Acacia gum, rice flour.|
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