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Sarcosine Supplement
Sarcosine Supplement
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Sarcosine
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Our Sarcosine supplement supports emotional well-being and provides brain nutrition.

  • Supports the body in adapting better to life's challenges.
  • Facilitates motivation and decision-making.
  • Supports cognition, including memory, rate of recall, and development of learning capacity.
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Sarcosine molecule and molecular structure

Sarcosine Supplement

Our sarcosine supplement provides nootropic effects and helps support emotional well-being. As with any nootropic, it helps the body adapt better to life's challenges, facilitates motivation and decision-making, and aids cognitive and neurosensory processes as a whole.

On this page, we will look closer at what sarcosine is, how it affects the brain, and what benefits you may receive from taking it on a regular basis. You will also learn about potential sarcosine side effects, as well as the appropriate way to take this high-quality supplement.

What is Sarcosine?

Sarcosine (N-methylglycine) is a methyl derivative of the amino acid glycine. It is found in egg yolk, turkey, ham, vegetables, and legumes. It was first isolated and named by the German chemist Justus von Liebig in the middle of the 19th century.

Sarcosine is naturally present in the body in muscles and various tissues via the enzyme glycine dehydrogenase. It is formed from choline intake and from the metabolism of methionine and is then broken down into glycine, an important constituent of protein.

Sarcosine contains a mild, sweet flavor that is quite distinct. In fact, it was used as the main ingredient in many types of toothpaste for several decades. Studies even show that a particular form of sarcosine may help combat cavities. It also creates the foaming action that people expect to see in a toothpaste.

However, toothpaste is no longer the primary purpose of sarcosine. With extensive research, many sarcosine supplement benefits have been found related to mental health.

Sarcosine may also aid memory and learning, as it has been shown to support brain health, in addition to mental health. Let's take a closer look at the science behind this supplement.

What Are Sarcosine's Effects on the Brain?

The human brain is by far the most complex organ in the body. It weighs only three pounds, but it is responsible for interpreting senses, initiating body movement, and controlling behavior.

Over time, the deterioration of the brain can lead to major neurological problems, including confusion and dementia. And, when ignored, the brain's nerves and tissue can even deteriorate completely.

Sarcosine affects the brain because of its relationship to GlyT1, a transporter that moves glycine and D-serine to the cells. With this transportation, the body's levels of D-serine and glycine increase.

D-serine is an amino acid located in the brain. It activates neurotransmitter receptors called NMDA receptors, needed for the formation of new synapses and vital for learning and memory.

Glycine is an amino acid the body needs for protein creation. These proteins are used for tissue growth and maintenance. They also create enzymes and hormones. Studies show this is one of three amino acids needed to make glutathione, an antioxidant that protects your cells from oxidative damage.

Research shows that glycine also calms the brain, allowing you to fall asleep easier and possibly sleep for longer. Furthermore, glycine is one of the main amino acids found in collagen, a core structural protein found in connective tissue needed for bone, ligament, skin, cartilage, and tendon health.

With the role sarcosine plays in promoting glycine and D-serine production, it is no wonder there are so many benefits from taking a sarcosine dietary supplement. We will take a closer look at what this supplement can be used for and the connection between sarcosine and cognition support.

Sarcosine Benefits

What benefits can you expect to receive from sarcosine? This supplement is essential for muscle synthesis and composition, but it is also the principal metabolic source of glutathione, creatine, and serine. In addition to its critical role in metabolic processes, there are three main sarcosine benefits:

  • It naturally increases levels of male reproductive hormone when combined with D-aspartic acid. By encouraging the production of GnRH by the hypothalamus, it boosts the release of FSH and LH, which in turn stimulates the testes to produce more male reproductive hormone.
  • It inhibits the transport of type 1 glycine (GlyT-1) and therefore increases glycine concentrations in the brain – activating N-methyl-D-aspartate (NMDA) receptors.
  • It may aid cognition and mental processes, including memory and recall rate, as well as the capacity for learning. These effects may be linked to its impact on glycine receptors in the brain.

Sarcosine capsules constitute a new nootropic, along with other supplements, such as Noopept and AFA extract, available to buy at Supersmart. Supplementation of sarcosine benefits healthy adults who are looking to alleviate degenerative cognition problems.

Sarcosine Side Effects

Before you buy a sarcosine supplement, you need to understand its potential side effects. While sarcosine supplements are considered safe in most situations, there are times when it is best to seek professional guidance from your healthcare practitioner before starting to take them daily.

We also recommend to use caution when taking a sarcosine nutritional supplement with any other medications or supplements. It is always best to review the supplements and medications you are taking with your doctor to avoid any negative reactions.

If you suffer from any underlying conditions, you should consult your doctor before beginning any supplement regimen. And while some studies suggest sarcosine may be effective in improving brain functionality and emotional well-being, you should still talk to your doctor before taking it.

As with any new supplement, watch for signs of interactions once you begin your new regimen. If anything out of the ordinary occurs, stop using it immediately and talk with your doctor. You may notice side effects when starting a new supplement. And, although some could be considered normal, it is always best to talk with someone who understands your health care needs to determine that.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Composition
Daily dose: 6 capsules
Number of doses per pack: 16
Amount per dose
Sarcosine 3 000 mg
Other ingredients: Acacia gum, rice flour.
Directions for use
adults. Take 3 to 6 capules a day.
Each capsule contains 500 mg of sarcosine.
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References
  1. Allen RH, Stabler SP, Lindenbaum J (November 1993). "Serum betaine, N,N-dimethylglycine and N-methylglycine levels in patients with cobalamin and folate deficiency and related inborn errors of metabolism". Metabolism. 42 (11): 1448–60. doi:10.1016/0026-0495(93)90198-W. PMID 7694037.
  2. Guastella J, Brecha N, Weigmann C, Lester HA, Davidson N. Cloning, expression, and localization of a rat brain high-affinity glycine transporter. Proc Natl Acad Sci U S A. 1992;89(15):7189–93.
  3. Zhang HX, Lyons-Warren A, Thio LL. The glycine transport inhibitor sarcosine is an inhibitory glycine receptor agonist. Neuropharmacology. 2009;57(5–6):551–5.
  4. Zhang HX, Hyrc K, Thio LL. The glycine transport inhibitor sarcosine is an NMDA receptor co-agonist that differs from glycine. J Physiol. 2009;587(Pt 13):3207–20.
  5. Huang CC, Wei IH, Huang CL, Chen KT, Tsai MH, Tsai P, Tun R, Huang KH, Chang YC, Lane HY, Tsai GE. Inhibition of glycine transporter-I as a novel mechanism for the treatment of depression. Biol Psychiatry. 2013;74(10):734–41.
  6. Lane HY, Liu YC, Huang CL, Chang YC, Liau CH, Perng CH, Tsai GE. Sarcosine (N-methylglycine) treatment for acute schizophrenia: a randomized, double-blind study. Biol Psychiatry. 2008;63(1):9–12.
  7. Singh SP, Singh V. Meta-analysis of the efficacy of adjunctive NMDA receptor modulators in chronic schizophrenia. CNS Drugs. 2011;25(10):859–85.
  8. Strzelecki D, Szyburska J, Rabe-Jablonska J. Two grams of sarcosine in schizophrenia - is it too much? A potential role of glutamate-serotonin interaction. Neuropsychiatr Dis Treat. 2014;10:263–6.
  9. Lee, MY., Lin, YR., Tu, YS. et al. Effects of sarcosine and N, N-dimethylglycine on NMDA receptor-mediated excitatory field potentials. J Biomed Sci 24, 18 (2017). https://doi.org/10.1186/s12929-016-0314-8
  10. Curtis, D. (2019). A possible role for sarcosine in the management of schizophrenia. British Journal of Psychiatry, 215(6), 697-698. doi:10.1192/bjp.2019.194

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