Osteoarthritis of the hands: a clinical trial tests the turmeric-boswellia combination

Why study the turmeric-boswellia combination for osteoarthritis of the hands?

Osteoarthritis is a chronic joint condition in which the cartilage covering the bones gradually breaks down. Joint discomfort can particularly affect the fingers and hands.

It is associated with inflammation, which causes disability and pain in the hands, as well as oxidative stress (1).

As part of a natural management approach, turmeric (Curcuma longa) and boswellia (Boswellia serrata) are attracting particular attention from researchers.

As a source of curcuminoids, including curcumin, turmeric is traditionally associated with maintaining joint health. It is used in particular to relieve inflammatory pain and maintain joint flexibility.

Boswellia resin, meanwhile, contains boswellic acids, which are being studied for their potential effect on joint comfort and the health of bones and joints in general.

According to some scientific studies, these compounds may modulate pathways involved in the inflammatory response and oxidative stress, as well as influencing the degradation of the cartilage matrix (2).

Experimental studies now suggest that curcumin and boswellic acids may act via distinct but complementary mechanisms, justifying the benefits of combining them (3).

A clinical study on turmeric and boswellia for osteoarthritis pain in the hands

A further reduction in pain compared with placebo

Published in 2025, the study followed 162 people aged 40 or over suffering from symptomatic osteoarthritis of the hands (4).

This multicenter, randomised, double-blind, placebo-controlled trial compared the daily intake of two tablets of a formula combining specific patented extracts of Curcuma longa and Boswellia serrata, as well as vitamin D3, with that of a placebo over a three-month period.

It was therefore not simply a mixture of plant powders.

The primary outcome measure was the change in pain on a visual analog scale ranging from 0 to 100 mm: the higher the score reported by the participant, the greater the pain experienced.

After three months, the study showed that the pain score had decreased more significantly in those who received the formula under investigation than in those taking the placebo.

In addition to pain scores, the participants’ overall assessment and certain quality-of-life indicators also improved favourably over the same period.

Results observed after 3 months in a multicenter, randomised, double-blind, placebo-controlled trial involving 162 people with symptomatic osteoarthritis of the hands (4).

Encouraging results for osteoarthritis of the hands

The results of this study are of interest, as few trials to date have specifically investigated this type of plant extract in osteoarthritis of the fingers and hands.

By focusing solely on this specific area, the study also has methodological strengths, as it was randomised and conducted as a double-blind, placebo-controlled trial across several centers.

However, certain limitations mean that the results should be interpreted with caution. On the one hand, the trial lasted only three months and involved a relatively small sample size.

Furthermore, in the absence of imaging, it is not possible to determine whether the structure of the joints has changed.

Finally, the results relate to a specific formulation based on patented extracts of turmeric and boswellia: they cannot therefore be extrapolated to just any supplement containing these plants at present.

This combination appears here to be a promising avenue for joint comfort, but its effectiveness will need to be confirmed by further research.

Are all turmeric and boswellia extracts equally effective?

Simply labelling a product ‘turmeric’ or ‘boswellia’ is not enough to determine the quality of an extract.

The extraction process, standardisation for active compounds and the bioavailability of these compounds are also important criteria to take into account.

Turmeric and boswellia extracts in separate individual formulations

Turmeric presents a challenge in terms of formulation due to the naturally low bioavailability of curcumin.

Various technologies therefore exist to improve its absorption.

One of these is the combination of curcuminoids with phospholipids, which help facilitate their passage into the bloodstream (5).

Discover the Super Curcuma dietary supplement, a turmeric extract standardized for curcuminoids and combined with Meriva® phosphatidylcholine to enhance their absorption.

Boswellia, for its part, contains various boswellic acids, one of the most extensively studied being AKBA.

To benefit from its documented biological properties, it is therefore recommended to choose a boswellia extract with a standardized composition (6).

Discover the Super Boswellia dietary supplement, a Boswellia serrata extract standardized to 20% AKBA.

It is entirely possible to combine these two types of extract to maximise their benefits for joint health. However, they are not the exact equivalent of the formula studied in the clinical trial discussed in this article.

Formulas combining turmeric and boswellia

Because they complement each other, turmeric and boswellia are sometimes combined in a single oral formula.

They may also be combined with other ingredients that have been studied for their benefits to joint health.

Discover the InflaRelief Formula dietary supplement, which combines 12 targeted active ingredients, including the patented Curcumin C3 Complex® standardized for curcuminoids and the patented boswellia extract standardized for AKBA 5-Loxin®.

Topical treatments based on plant extracts

To treat painful joints, there are also creams and topical treatments that can be applied to the affected areas.

However, their local action differs from the effects observed in the clinical trial discussed in this article (7).

Discover Smart Joints Cream, a topical treatment containing, amongst other ingredients, boswellia, eucalyptus, MSM and glucosamine.

What other approaches are there to promote joint comfort?

Joint comfort depends on various factors, which explains the interest in active ingredients other than boswellia or turmeric. For example:

• Type II collagen is known to be one of the main components of joint cartilage (8).
• PEA (9), ginger (10) and MSM (11) are the subject of research into joint comfort and mobility.
• Vitamin C has an antioxidant effect and contributes to the normal formation of collagen, which is necessary for the proper functioning of cartilage.

Discover the Arthro Fast Relief dietary supplement, which combines native type II collagen Collavant® n2, the patented PEA Levagen®+, Ferzinger® fermented ginger, MSM, vitamin C and astaxanthin.

Furthermore, bear in mind that dietary supplements are just one approach amongst many.

Maintaining finger mobility, doing suitable hand exercises and following the advice of a healthcare professional remain essential for preserving joint health.

Finally, osteoarthritis requires appropriate management: no supplement can replace the measures and treatments prescribed by a doctor.