NMN supplement and precursor of NAD+ – repairs channels between cells

Nicotinamide mononucleotide (NMN) is a precursor of NAD+ (nicotinamide adenine nucleotide) and NADH biosynthesis, delivered in vegetarian capsules and providing anti-aging benefits. This new compound should not, however, be confused with nicotinamide riboside (NR) and other substances already on the market, even though they may share certain properties, particularly at a genetic level; NMN is significantly more powerful than NR.

Finding a way of stopping the aging process has been part of dreams for generations. But now, it is on the way to becoming a reality since Australian and American scientists believe they have found a way of not just pausing the aging process, but rewinding it.

What are the benefits associated with Nicotinamide Mononucleotide?

At a conference on the biology of aging organized by the Ellison Medical Foundation, Dr. Shin-Ichiro Imai demonstrated that sirtuins are necessary for calorie restriction to improve the activity of orexin, a brain hormone which enhances cells' sensitivity to the hormone that regulates blood sugar and prevents increases in body fat.

However, sirtuins alone are not enough – cellular NAD+ must also be present for these beneficial processes to work. The problem is that levels of NAD+ decline both with age and as a result of a high-fat diet. The good news, according to Dr. Imai, is that in NMN-treated mice, researchers observed an increase in NAD+ synthesis, suggesting NMN could be a potential treatment for type 2 diabetes.

• NMN not only helps extend life expectancy but has also shown promise in treating type 2 diabetes.
• This degenerative disease is directly linked to overconsumption of fat and calories which overwhelm adaptive metabolic pathways.
• Mouse studies showed that NMN improved glucose tolerance by restoring NAD+ levels.
• It enhances sensitivity to the hormone that regulates blood sugar in the liver, restores impaired gene expression related to oxidative stress, as well as the inflammatory response, and the circadian rhythm by activating SIRT1.

What is NAD+?

Found in all living cells, NAD+ is a coenzyme involved in redox reactions. It consists of two nucleotides linked by their phosphate group. One nucleotide contains an adenine, the other, a nicotinamide. It helps enzymes transfer electrons during redox reactions to form ATP and is thus an aid to energy supply.

However, levels decline with age – the NAD+ in a middle-aged person's cells will have fallen to half of its youthful levels. Mitochondria then produce less energy, and cells age. Fortunately, this process is not irreversible, and intercellular energy mechanisms can be restored if levels of NAD+ are increased.

In addition, NAD is an essential cofactor of key longevity enzymes called sirtuins, which it activates directly. Sirtuins play a fundamental role in life expectancy since they deactivate particular genes that lead to aging via inflammatory processes. Thus, the combined fall in sirtuins 1 and 3, and in NAD+, can cause cerebral degeneration, vascular inflammation, fatigue, loss of muscle strength, increased fat stores around the liver and abdomen, and resistance to the hormone that regulates blood glucose levels, leading directly to metabolic syndrome. All of these processes can be reversed by means of calorie restriction or supplementation with nicotinamide mononucleotide.

What do studies show about Nicotinamide Mononucleotide?

• An experiment on NMN in mice conducted by Professor David Sinclair from Harvard Medical School has produced impressive clinical results and may lead to the development of new treatments to combat aging and its associated diseases (cancer and type 2 diabetes).
• When Professor Sinclair and his colleagues injected this rare substance into two-year-old mice, they observed, after just one week's treatment, notable muscle improvement (a reduction in muscle atrophy), enhanced resistance to the hormone that regulates blood sugar, and reduced inflammation, making the mice indistinguishable from younger animals.
• According to Dr. Nigel Turner, a pharmacologist at the University of New South Wales, "it's like a 60-year-old being similar to a 20-year-old on some measures." Professor Sinclair added: "If these results stand, then aging may be a reversible condition, if it is caught early."
• In a report published in the journal Cell, researchers clearly show how the NMN injected into the animals converts into NAD to repair the compromised communication channels within a very short timescale – less than a week, in fact.
• The activity described by Professor Sinclair, who was previously responsible for research into resveratrol, highlights NMN's ability to activate all seven of the SIRT genes involved in extending longevity.
• He believes nicotinamide mononucleotide could be a new class of super drug capable of both preventing diseases such as cancer (via inhibition of HIF-1, a molecule that impairs intracellular communication and plays a role in cancer development) and Parkinson's disease, as well as extending life expectancy to 150 years.
• In humans, as in mice, nicotinamide mononucleotide, at an average daily dose of 125 mg – 1 capsule a day – could produce a natural reversal of the aging process. According to Professor Sinclair, this substance is fast-acting and could also benefit young, healthy people.

Why is it important to supplement with Nicotinamide Mononucleotide?

The mitochondria are at the heart of the problem. When they stop communicating properly with the cell nucleus, it is almost as if the cells are deprived of their energy source or battery – their nuclei shrink, and aging becomes inevitable. For Professor David Sinclair, "the aging process can be compared to a married couple – when they are young, they communicate well, but over time, communication breaks down. And just as with a married couple, restoring communication solves the problem."

Pr. Sinclair thus sees the decline in mitochondrial function and communication as a reversible process. He explains that NAD+ is the central pillar of cell communication but that it decreases sharply with age – until now, the only known way of preventing this loss has been through intensive exercise or calorie restriction.

In addition to this innovative formulation, you may also be interested in other anti-aging supplements that offer effective and long-lasting protection from the effects of aging, available to buy at Supersmart. The potent AMPK Booster, for example, is formulated to reactivate AMPK, a key enzyme of metabolism, levels of which decline with age. The complex Natural Rapalogs contains five natural inhibitors of mTOR proteins, inhibition of which may combat premature aging. You can also benefit from the optimized formulation Longevity Nutrients, which combines a selection of natural anti-aging nutrients.

Buy Nicotinamide Mononucleotide capsules to fight the aging process naturally.

Why Should I Buy NMN Supplements on Supersmart?

When you buy your NMN supplement online, you need to ensure that you have vetted your vendor of choice. Choosing a vendor like Supersmart means choosing a company that goes the extra mile to ensure the safety and efficacy of your nicotinamide mononucleotide supplement.

All of our supplements are ethically sourced and independently tested to ensure you get the nicotinamide mononucleotide benefits you expect. We also comb through the scientific material available to ensure that any supplement featured on our platform is safe for human consumption and effective.

Make the Supersmart choice and buy NMN from us.

Is Nicotinamide Mononucleotide Safe?

Before taking NMN capsules as part of your diet, you need to ensure these are the right supplements for you. Overall, nicotinamide mononucleotide capsules are enjoyed by millions worldwide without any adverse side effects.

However, taking control of your health means researching and analyzing your supplementary regime. Plenty of research exists on NMN supplements online. Read some scientific studies and talk to others who have already made this supplement a regular part of their diets.

It is vital that you monitor how you react to these supplements. While the majority will never experience any serious side effects, you must be extra careful if you take any prescription medications for acute or chronic conditions. Schedule an appointment with your doctor and tell them you plan to include an NMN NAD supplement in your diet.

Your doctor can advise you on whether you should take an NMN supplement or whether any alternate supplements may support your health and fitness goals.

How Should I Take these Nicotinamide Mononucleotide Capsules?

Each Super NMN capsule contains 125 mg of this compound. The average human can safely consume up to 1,200 mg daily without experiencing serious adverse health effects. However, it is strongly recommended that you take just one capsule to achieve the nicotinamide mononucleotide anti-aging benefits you expect.

Avoid exceeding the recommended daily dosage on the bottle. Most mild side effects result from people attempting to consume too much to amplify their benefits.

Always take NMN on an empty stomach. The problem with this compound is that stomach acid destroys it. These capsules contain a relatively large amount of NMN because most of it will be destroyed naturally in your stomach.

When consuming food, especially fatty foods, the presence of something in your stomach triggers it to make more acid. Although you can consume these capsules after a meal, you will not enjoy the full benefits.

As with any supplement, monitor yourself for any side effects. If you experience any uncomfortable sensations, stop taking this supplement and consult your doctor for advice.

1. Abhirup Das, George X. Huang, Michael S. Bonkowski et al. Impairment of an Endothelial NAD -H 2 S Signaling Network Is a Reversible Cause of Vascular Aging. Cell, 2018; 173 (1): 74 DOI: 10.1016/j.cell.2018.02.008