What is a Calcium AKG Supplement?
Calcium AKG is a highly dosed calcium alpha-ketoglutarate (Ca-AKG) dietary supplement.
Alpha-ketoglutarate (AKG) is a molecule naturally involved in cellular energy production and has been studied for its potential role in healthy aging. When combined with calcium, AKG becomes more stable and bioavailable.
Calcium AKG is classified in our Longevity category.
Benefits of Calcium Alpha-Ketoglutarate
Definition and role of alpha-ketoglutarate (AKG)
Alpha-ketoglutarate (AKG) is an organic acid naturally present in the body that plays a key role in the Krebs cycle, a central metabolic pathway that takes place in the mitochondria.
This cycle is essential for energy metabolism (ATP production) and for mitochondrial function, which is closely linked to the vitality and longevity of cells.
Researchers suggest AKG may:
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activate the AMPK pathway, supporting energy balance and cellular repair;
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influence the mTOR pathway, helping promote autophagy (a natural cell renewal process);
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help regulate inflammatory balance by modulating pathways associated with oxidative stress.
Alpha-ketoglutarate levels and aging
AKG levels tend to decline with age, being up to 10 times lower at 80 than at 40. This reduction is linked with decreased mitochondrial efficiency and higher oxidative stress.
Animal and early human studies have investigated AKG supplementation for its potential to support longevity and cellular health (1-4).
Combining AKG with calcium to form calcium alpha-ketoglutarate helps improve its bioavailability and stability for oral use.
The 3 Strengths of our Calcium AKG Supplement
Our formula stands out from other AKG supplements for three reasons:
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Enhanced bioavailability with calcium: binding AKG to calcium forms a stable salt called calcium alpha-ketoglutarate (Ca-AKG). This pairing helps improve stability, absorption, and effectiveness. Calcium also contributes to normal energy metabolism, muscle function, and plays a role in cell division.
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High and safe daily dosage: our supplement provides 1,000 mg of calcium alpha-ketoglutarate per day, a dosage aligned with those studied in scientific research on metabolism and healthy aging.
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Clean, plant-based formulation: packaged in 100% vegan capsules (hypromellose, HPMC) with acacia gum as the only excipient. Free from GMOs, nanoparticles, gluten, and lactose.
Where to Buy Alpha Ketoglutarate Supplements?
If you’re searching for where to buy alpha ketoglutarate supplements, look for brands that clearly state the AKG form (Ca-AKG, AAKG), the dosage per serving, complementary ingredients, and provide transparency on third-party testing and GMP manufacturing standards.* Reputable retailers also offer clear batch tracking, return policies, and customer support to ensure product authenticity and proper handling.*
WARNINGS
Do not exceed the recommended daily dose. This product is a nutritional supplement and should not be used as a substitute for a varied and balanced diet or a healthy lifestyle.
STORAGE
Store in a cool, dry place away from direct sunlight, heat, and humidity.
Keep out of reach of children.
PREGNANCY AND MEDICAL CONDITIONS
If you are pregnant, breastfeeding, or have any medical conditions, consult your healthcare provider before using this product.
SUPPLEMENT INTERACTIONS
Consult your healthcare provider before use, especially if you are taking any medications or other supplements as there may be potential interactions.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Daily dose: 2 capsules
Number of doses per box: 30
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Daily dose
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Calcium alpha-ketoglutarate
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1,000 mg
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Other ingredients: hypromellose capsule, gum acacia.
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Serving size: Take 2 capsules per day.
Servings per container: 30
Storage: Store away from direct light, heat, and humidity.
Cautions: For adults only. Do not exceed the recommended daily dose. Keep out of reach of children. Consult a healthcare provider before taking this supplement and if you are pregnant, breastfeeding, or having health concerns.*
This product is a dietary supplement and should not be used as a substitute for a varied, balanced diet and a healthy lifestyle.
- Asadi Shahmirzadi A, Edgar D, Liao CY, Hsu YM, Lucanic M, Asadi Shahmirzadi A, Wiley CD, Gan G, Kim DE, Kasler HG, Kuehnemann C, Kaplowitz B, Bhaumik D, Riley RR, Kennedy BK, Lithgow GJ. Alpha-Ketoglutarate, an Endogenous Metabolite, ... Mice. Cell Metab. 2020 Sep 1;32(3):447-456.e6. doi: 10.1016/j.cmet.2020.08.004. PMID: 32877690; PMCID: PMC8508957.
- Chin RM, Fu X, Pai MY, Vergnes L, Hwang H, Deng G, Diep S, Lomenick B, Meli VS, Monsalve GC, Hu E, Whelan SA, Wang JX, Jung G, Solis GM, Fazlollahi F, Kaweeteerawat C, Quach A, Nili M, Krall AS, Godwin HA, Chang HR, Faull KF, Guo F, Jiang M, Trauger SA, Saghatelian A, Braas D, Christofk HR, Clarke CF, Teitell MA, Petrascheck M, Reue K, Jung ME, Frand AR, Huang J. The metabolite α-ketoglutarate ... . Nature. 2014 Jun 19;510(7505):397-401. doi: 10.1038/nature13264. Epub 2014 May 14. PMID: 24828042; PMCID: PMC4263271.
- Lylyk, M. P., Bayliak, M. M., Shmihel, H. V., Storey, J. M., Storey, K. B., & Lushchak, V. I. (2018). ... of alpha‑ketoglutarate ... . Ukrainian Biochemical Journal, 90(6), 49–61. ISSN 2409‑4943. DOI: 10.15407/ubj90.06.049
- Naeini SH, Mavaddatiyan L, Kalkhoran ZR, Taherkhani S, Talkhabi M. Alpha-ketoglutarate as a ... : Evidences and perspectives. Exp Gerontol. 2023 May;175:112154. doi: 10.1016/j.exger.2023.112154. Epub 2023 Mar 20. PMID: 36934991.