Dietary supplement for endometriosis, effective and hormone-free

Endometriosis Support is a dietary supplement designed to support women in managing their endometriosis.

Hormone-free, it contains only ingredients which scientific studies show have the potential to reduce endometriosis and its symptoms.

This supplement is part of our menstrual cycle product category.

Composition and benefits of this supplement for endometriosis

Endometriosis: definition & symptoms

Before describing the ingredients in the product, let’s briefly restate that endometriosis is a gynaecological condition characterised by the abnormal proliferation of endometrium-like tissue (tissue similar to the lining of the uterus) outside of the uterus.

The causes of this condition are poorly-understood but we do know it can give rise to various symptoms: inflammation, intestinal problems, intense pain (during a period, the excess tissue reacts to menstrual hormones and bleeds, but unlike a period, this blood has no way of escaping, leading to the formation of cysts, lesions, etc.) and fertility problems.

Benefits of the 5 ingredients in this hormone-free supplement

Endometriosis Support contains 5 ingredients carefully selected for their potential benefits against endometriosis:

• palmitoylethanolamide (PEA): PEA is a fatty acid derivative naturally produced by the body’s cells to reduce inflammation (1). A meta-analysis of 4 studies showed promising effects from the administration of PEA in cases of endometriosis-induced pain (2);
• N-acetylcysteine (NAC): NAC is a synthetic derivative of cysteine with greater stability and absorbability than cysteine itself. In vitro studies have shown NAC to have an antiproliferative action, which is particularly relevant in cases of endometriosis (3). Meanwhile animal studies have shown NAC to produce a significant reduction in the average size of lesions (4). Researchers have also observed a decrease in the size of endometriomas (painful cysts) in NAC-supplemented women and believe this compound can help combat ovarian endometriosis and prevent its recurrence (5);
• alpha-lipoic acid (ALA): ALA is an antioxidant organosulfur compound, small amounts of which are produced naturally by the body. Animal and human studies on subjects with endometriosis have suggested that supplementation with alpha-lipoic acid can reduce oxidative stress, decrease the volume of endometrial implants (6) and alleviate the pain associated with endometriosis (painful periods (dysmenorrhea), pain related to sexual intercourse (dyspareunia), mild to severe pelvic pain, etc.) (7);
• magnesium bisglycinate: magnesium supports normal muscle function which can help regulate spasms, cramps and contractions. This mineral relaxes smooth muscle in particular, which may reduce retrograde menstruation (when menstrual blood containing fragments of endometrial cells flows back into the pelvic cavity, a potential cause of endometriosis). It also supports normal nervous system function, potentially inhibiting nerve hyperexcitability, and helps to reduce the fatigue often caused by endometriosis. This mineral is also being studied for its potential to restrict angiogenesis (the formation of new blood vessels, a process which can aggravate endometriotic lesions) (8);
• trans-resveratrol from Japanese knotweed: trans-resveratrol is the most active form of resveratrol, a polyphenol found in grapes, blackberries and especially Japanese knotweed (Polygonum cuspidatum). Resveratrol is being studied for its potential anti-inflammatory, anti-angiogenesis and antioxidant benefits in the context of endometriosis (9-12). An in vitro study has also shown that resveratrol can induce apoptosis (programmed cell death) of endometrial cells, thus helping to reduce lesions (13).

The 5 key strengths of this natural solution for combatting endometriosis

Endometriosis Support, a major nutritional ally in fighting endometriosis, is notable in 5 key aspects:

1. its scientifically-supported synergy: the efficacy of the compounds in this product have been tested in studies on endometriosis. You can take it, with the approval of your gynaecologist, as an adjunct to conventional medical treatment. The composition of Endometriosis Support makes it suitable for long term use, with the minimum side-effects possible;
2. its highly-bioavailable forms: we have selected the best forms available for each of its ingredients. Trans-resveratrol, for example, is the most stable and bio-assimilable form of resveratrol. Similarly, magnesium bisglycinate is known for being both easily-usable by cells and the best-tolerated form in terms of digestion;
3. its optimal dose: its ingredients are all included at powerful but safe doses;
4. its absence of hormones: unlike many supplements for endometriosis which include plants containing phytohormones such as chasteberry (Agnus castuseither synthetic or phytohormones) in order to prevent any disruption to hormonal balance, which is already delicate in many endometriosis-sufferers;
5. its natural form of delivery: Endometriosis Support comes in the form of vegetarian capsules. The only excipient, acacia gum, is a totally natural ingredient.