PermeaGut Formula is a dietary supplement that combines key nutrients studied for their potential role in supporting digestive wellness and the normal function of the intestinal lining.*
Sometimes, people use the expression "leaky gut" as an informal way to describe changes in digestive balance and intestinal comfort. While not a medical diagnosis, it reflects interest in maintaining everyday wellness and healthy barrier function.*
PermeaGut Formula is part of our category dedicated to Digestive & Gut Health.*
What Natural Options May Help Support Digestive Balance?*
Understanding Digestive Wellness*
The intestine plays an important role in digestion and nutrient absorption. Lifestyle factors such as stress, diet, or microbial shifts may influence this balance.*
Research has explored how certain nutrients may help maintain digestive comfort and support the normal function of intestinal tissues.*
Composition and Potential Benefits of Our Formula*
PermeaGut Formula combines 6 carefully selected nutrients that have been studied for their possible roles in digestive wellness and maintaining a balanced intestinal environment.*
- L-glutamine: an amino acid naturally present in the body, studied for its possible role in supporting intestinal comfort and tissue balance.*
- Zinc L-carnosine: zinc contributes to the normal function of the immune system and the maintenance of normal cells and tissues.* Research has explored zinc-L-carnosine for digestive support and wellness.*
- Butyrate (ButiShield™): a short-chain fatty acid, microencapsulated here for targeted release. It has been studied for its potential role in intestinal comfort and supporting microbial balance.*
- Beta-carotene (vitamin A): contributes to the maintenance of normal mucous membranes, including those in the intestine.*
- Vitamin D3: contributes to the normal functioning of the immune system and may play a role in supporting overall balance.*
- Quercetin: a flavonoid that has been studied for its potential role in antioxidant support and maintaining general digestive wellness.*
4 Key Features of PermeaGut Formula*
- A multifactorial approach: combines six nutrients studied for digestive comfort, immune balance, and general intestinal wellness.*
- Thoughtful formulation: includes specialized compounds such as ButiShield™ butyrate and zinc L-carnosine, provided at meaningful levels.*
- Gastro-resistant capsules: designed to withstand stomach acid and support the targeted release of ingredients.*
- Clean composition: plant-based capsules (hypromellose), free from unnecessary additives.*
WARNINGS
Do not exceed the recommended daily dose. This product is a nutritional supplement and should not be used as a substitute for a varied and balanced diet or a healthy lifestyle.
STORAGE
Store in a cool, dry place away from direct sunlight, heat, and humidity.
Keep out of reach of children.
PREGNANCY AND MEDICAL CONDITIONS
If you are pregnant, breastfeeding, or have any medical conditions, consult your healthcare provider before using this product.
SUPPLEMENT INTERACTIONS
Consult your healthcare provider before use, especially if you are taking any medications or other supplements as there may be potential interactions.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Daily dose: 6 capsules
Number of doses per box: 30
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Daily dose
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L-glutamine
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3,000 mg
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Anhydrous quercetin extracted from Sophora japonica
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240 mg
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ButiShield™
35% microencapsulated calcium butyrate
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200 mg
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Zinc L-carnosine
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50 mg
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Beta-carotene
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7 mg
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Vitamin D3
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1,000 IU
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Other ingredient: hypromellose capsule.
ButiShield™ is a registered trademark of Kemin Industries, Inc.
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Serving size: Take 2 capsules 30 minutes before each of the three main meals.
Servings per container: 30
Storage: Store in a cool, dark, and dry place.
Cautions: For adults only. Do not exceed the recommended daily dose. Keep out of reach of children. Consult a healthcare provider before taking this supplement and if you are pregnant, breastfeeding, or having health concerns.*
This product is a dietary supplement and should not be used as a substitute for a varied, balanced diet and a healthy lifestyle.
- Wang B, Wu G, Zhou Z, Dai Z, Sun Y, Ji Y, Li W, Wang W, Liu C, Han F, Wu Z. Glutamine and intestinal barrier function. Amino Acids. 2015 Oct;47(10):2143-54. doi: 10.1007/s00726-014-1773-4. Epub 2014 Jun 26. PMID: 24965526.
- Zhou Q, Verne ML, Fields JZ, Lefante JJ, Basra S, Salameh H, Verne GN. Randomised placebo-controlled trial of dietary glutamine supplements for … . Gut. 2019 Jun;68(6):996-1002. doi: 10.1136/gutjnl-2017-315136. Epub 2018 Aug 14. PMID: 30108163; PMCID: PMC9549483.
- Kim MH, Kim H. The Roles of Glutamine in the Intestine and Its … in Intestinal … . Int J Mol Sci. 2017 May 12;18(5):1051. doi: 10.3390/ijms18051051. PMID: 28498331; PMCID: PMC5454963.
- Shu XL, Yu TT, Kang K, Zhao J. … of glutamine on markers of … and … : A meta-analysis. Exp Ther Med. 2016 Dec;12(6):3499-3506. doi: 10.3892/etm.2016.3799. Epub 2016 Oct 12. PMID: 28105083; PMCID: PMC5228558.
- Achamrah N, Déchelotte P, Coëffier M. Glutamine and the … of intestinal ... : from bench to bedside. Curr Opin Clin Nutr Metab Care. 2017 Jan;20(1):86-91. doi: 10.1097/MCO.0000000000000339. PMID: 27749689.
- Mahmood A, FitzGerald AJ, Marchbank T, Ntatsaki E, Murray D, Ghosh S, Playford RJ. Zinc carnosine, … . Gut. 2007 Feb;56(2):168-75. doi: 10.1136/gut.2006.099929. Epub 2006 Jun 15. PMID: 16777920; PMCID: PMC1856764.
- Efthymakis K, Neri M. The role of Zinc L-Carnosine in the … in humans: a review. Clin Res Hepatol Gastroenterol. 2022 Aug-Sep;46(7):101954. doi: 10.1016/j.clinre.2022.101954. Epub 2022 Jun 2. PMID: 35659631.
- Finnie IA, Dwarakanath AD, Taylor BA, Rhodes JM. … synthesis is increased by sodium butyrate. Gut. 1995 Jan;36(1):93-9. doi: 10.1136/gut.36.1.93. PMID: 7890244; PMCID: PMC1382360.
- Hamer HM, Jonkers D, Venema K, Vanhoutvin S, Troost FJ, Brummer RJ. Review article: the … butyrate … function. Aliment Pharmacol Ther. 2008 Jan 15;27(2):104-19. doi: 10.1111/j.1365-2036.2007.03562.x. Epub 2007 Oct 25. PMID: 17973645.
- Plöger S, Stumpff F, Penner GB, Schulzke JD, Gäbel G, Martens H, Shen Z, Günzel D, Aschenbach JR. Microbial butyrate and … in the gastrointestinal tract. Ann N Y Acad Sci. 2012 Jul;1258:52-9. doi: 10.1111/j.1749-6632.2012.06553.x. PMID: 22731715.
- Abdelhamid L, Luo XM. Retinoic Acid, … . Nutrients. 2018 Aug 3;10(8):1016. doi: 10.3390/nu10081016. PMID: 30081517; PMCID: PMC6115935.
- López-Muñoz P, Beltrán B, Sáez-González E, Alba A, Nos P, Iborra M. Influence of Vitamin D … . Nutrients. 2019 May 11;11(5):1059. doi: 10.3390/nu11051059. PMID: 31083541; PMCID: PMC6567866.
- Abbasnezhad A, Amani R, Hajiani E, Alavinejad P, Cheraghian B, Ghadiri A. … of vitamin D on … : a randomized double-blind clinical trial. Neurogastroenterol Motil. 2016 Oct;28(10):1533-44. doi: 10.1111/nmo.12851. Epub 2016 May 7. PMID: 27154424.
- Luthold RV, Fernandes GR, Franco-de-Moraes AC, Folchetti LG, Ferreira SR. Gut microbiota … of vitamin D in … individuals. Metabolism. 2017 Apr;69:76-86. doi: 10.1016/j.metabol.2017.01.007. Epub 2017 Jan 13. PMID: 28285654.
- Suzuki T, Hara H. Quercetin … intestinal barrier … through the assembly of zonula [corrected] occludens-2, occludin, and claudin-1 and the expression of claudin-4 in Caco-2 cells. J Nutr. 2009 May;139(5):965-74. doi: 10.3945/jn.108.100867. Epub 2009 Mar 18. PMID: 19297429.
- Shabbir U, Rubab M, Daliri EB, Chelliah R, Javed A, Oh DH. Curcumin, Quercetin, Catechins and …: The Role of Gut Microbiota. Nutrients. 2021 Jan 12;13(1):206. doi: 10.3390/nu13010206. PMID: 33445760; PMCID: PMC7828240.
- Sahoo DK, Heilmann RM, Paital B, Patel A, Yadav VK, Wong D, Jergens AE. … antioxidants … . Front Endocrinol (Lausanne). 2023 Aug 28;14:1217165. doi: 10.3389/fendo.2023.1217165. PMID: 37701897; PMCID: PMC10493311.