PermeaGut Formula Supplement to Help Support Digestive Wellness and Gut Barrier Integrity *

PermeaGut Formula is a dietary supplement that combines key nutrients studied for their potential role in supporting the integrity and balance of the intestinal barrier.*

"Leaky gut" is a commonly used term to describe a situation where intestinal permeability may be higher than normal.*

PermeaGut Formula is part of our category dedicated to Digestive & Gut Health.*

What Natural Options May Help Support Intestinal Barrier Health?*

What is Leaky Gut, and What May Help Support Intestinal Balance?*

Intestinal hyperpermeability, often referred to as leaky gut, describes a potential change in the natural barrier function of the intestine.* Various factors such as stress, dietary imbalances, microbial shifts, or certain lifestyle influences may play a role in this process.*

When the intestinal barrier is not functioning optimally, it may become more permeable. This can allow certain compounds (such as microbes or food particles) to cross into areas they normally would not. This change has been studied for its potential links to immune activity and digestive balance.*

Increased intestinal permeability is often discussed in the context of lifestyle and dietary choices.* Approaches that may be considered include adopting a more balanced diet, supporting microbial balance, and exploring nutritional supplements such as glutamine, which has been studied for its potential role in digestive wellness.*

Comparison between a healthy gut and a leaky gut, where the barrier becomes more permeable, which could allow certain compounds to pass more easily and influence overall balance in the body.*

Composition and Potential Benefits of Our Supplement*

PermeaGut Formula combines 6 carefully selected nutrients that have been studied for their potential role in supporting intestinal barrier health.*

• L-glutamine: an amino acid naturally produced by the body. It serves as an important fuel source for intestinal cells (enterocytes) and has been studied for its potential role in supporting intestinal barrier function and mucus layer maintenance.* Research suggests it may contribute to a balanced gut environment and overall digestive wellness.*
• L-carnosine zinc: a combination of zinc and the peptide L-carnosine. Zinc contributes to the normal function of the immune system and the maintenance of normal cells and tissues.* Studies have explored zinc-L-carnosine for its potential role in supporting the integrity of the intestinal lining and helping to promote overall digestive comfort.*
• Butyrate: a short-chain fatty acid naturally produced in the gut, studied for its potential role in supporting the intestinal lining by providing fuel for colon cells (colonocytes).* It may also play a part in maintaining tight junction integrity and supporting mucin production that contributes to the protective layer of the intestine.* ButiShield™ is a microencapsulated form designed for targeted release in the colon, with reduced odor and gradual delivery of the active compound.*
• Beta-carotene (vitamin A): in the body, beta-carotene can be converted into vitamin A, which contributes to the maintenance of normal mucous membranes, including those in the intestine.* Vitamin A also plays a role in the differentiation and renewal of epithelial cells, which are important for overall tissue balance and integrity.*
• Vitamin D3: also known as cholecalciferol, vitamin D3 contributes to the normal functioning of the immune system*. Research also suggests it may play a role in cell differentiation and could influence the balance of the gut microbiota*, which may be relevant for maintaining intestinal wellness.*
• Quercetin: a naturally occurring flavonoid that has been studied for its potential role in supporting immune balance*. Research suggests it may also influence proteins linked to tight junction function* in the intestinal lining and contribute to antioxidant support*, which together may help maintain overall gut wellness.*

4 Key Benefits of Our Supplement to Help Support Intestinal Barrier Health*

PermeaGut Formula is a synergistic blend of nutrients with 4 key strengths for supporting intestinal barrier wellness:*

1. A multifactorial approach: this carefully selected blend of ingredients is designed to support intestinal lining integrity, balanced immune function, and overall digestive comfort.*
2. Rare, carefully selected ingredients: unlike many standard formulas, this supplement features specialized compounds such as ButiShield™ butyrate and L-carnosine zinc, provided at meaningful levels studied for their potential to support digestive wellness.*
3. Its gastro-resistant capsules: designed to withstand stomach acid and support the targeted release of ingredients in the intestine, where they may be more available for use by the body.*
4. Its clean formulation: the capsules are plant-based (made from hypromellose) and free from unnecessary additives, offering a simple composition designed with digestive comfort in mind.*