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Xanthohumol Supplement
Xanthohumol Supplement
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Xanthohumol Supplement
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Xanthohumol is an extract of hop flowers with unique chemopreventive properties.

  • Contains xanthohumol, a natural antioxidant 200 times more powerful than resveratrol in red wine
  • Helps fight oxidative stress and maintain cells in optimal health
  • Promotes drowsiness and calms irritability (nervous tension, agitation)
  • Supports hormone balance (reduces hot flashes and other menopause symptoms)
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Three hop flowers

Xanthohumol Supplement - Antioxidant Extracted From Hops

Xanthohumol is a hop flower supplement containing an exceptional antioxidant flavonoid. The xanthohumol supplement is a phenolic compound that's 200 times more powerful than the resveratrol in red wine and offers truly exceptional cell-boosting properties. Beer is the only dietary source of xanthohumol, though the levels it contains are very low, which causes people to look closer at xanthohumol uses and how to get it. So, what does xanthohumol do and where does it come from?

What is xanthohumol?

Wine-lovers appreciate the drink's subtlety and sophistication but they also know it's an exceptionally rich source of antioxidants, one of which is the most studied anti-aging substance ever: resveratrol.

However, new research shows that beer is more than a match for its great rival.

Beer is the only dietary source of xanthohumol, a natural cytoprotective antioxidant that's 200 times more powerful than the resveratrol in red wine.

It was Hildegarde de Bingen, a 12th-century Benedictine nun and pharmacologist, who was responsible for introducing hops into beer. Before that, monks had used mainly coriander, gentian or sage to flavor and preserve their precious nectar, which was given to pilgrims in monasteries and abbeys.

It was immediately evident that the hop offered many benefits: with its preservative properties and positive effects, it quickly became an essential ingredient in the recipe. Over the centuries that followed, it would go on to be used by generations of brewers, right up to the present day.

Though the monks had no way of knowing it, its meteoric rise was due to the hop's high content in phenolic compounds, particularly xanthohumol. The problem is that these compounds, which come from the hop flower, are very delicate and tend to make the beer a bit cloudy.

That’s why the majority of modern, large-scale beer producers use a chemical (PVPP) to eliminate this cloudiness and prevent deposits from forming in the bottle. So in order to obtain the benefits of xanthohumol, you need to drink beers with a strong hop content, like an India Pale Ale (IPA).

But the best way of benefiting from this cytoprotective compound is to take a hop flower supplement, standardized in xanthohumol, every day. It's an ultra-modern solution (extracting the xanthohumol from the hop inflorescences is a major technological achievement) that draws on its ancient tradition of use and avoids the oxidative effects of alcohol.

Xanthohumol Benefits

What is xanthohumol used for? Hop flower extract standardized in xanthohumol offers four main benefits, all of which are backed up by scientific literature.

Here are some xanthohumol extract benefits to consider:

  • It supports optimal cellular health and combats oxidative stress. Xanthohumol and the phenolic compounds present in hop cones are the most effective natural antioxidants in the plant kingdom. In 2014, Professor Wang and his team showed that at the same concentration, they had greater antioxidant activity than the antioxidants in green tea. A number of studies have also demonstrated the broad-spectrum chemopreventive properties of xanthohumol on cells: induction of detoxification enzymes, inhibition of angiogenesis and inflammatory signals, cytoprotective effects, induction of apoptosis, inhibition of free radicals and procarcinogens.
  • It can help lower blood cholesterol levels. In 2017, scientists discovered that xanthohumol promotes HDL cholesterol in the blood, helping to clear arteries and tissues of oxidized cholesterol and direct it towards the liver where it is broken down. In addition, the other natural compounds that give hop its characteristics disrupt the molecular mechanisms responsible for the initiation, progression and rupture of the atherosclerotic plaques that cause strokes.
  • It's a valuable aid against sleep problems and nervous agitation. Did you know that in Belgium, where hops are widely grown, people are advised to put dried hop cones in their ears to improve their sleep? Research has indeed demonstrated that the compounds in hop produce similar effects to those of melatonin and can normalize circadian rhythms. Several studies have even shown a valerian and hop flower combination to be as effective for improving sleep as synthetic sleeping tablets, but without causing the side-effects associated with these drugs.
  • It reduces problems related to menopause. Hop flowers contain the most powerful phytoestrogen isolated to date: 8-Prenylnaringenin. It acts as a selective modulator of estrogen receptors, helping reduce discomfort associated with menopause, such as hot flushes. In addition, xanthohumol is a powerful inhibitor of the bone resorption responsible for osteoporosis.

Other studies have demonstrated its ability to regulate fat metabolism (by improving lipid parameters) and to boost the body's defenses and vitality. By no means exhaustive, this list identifies xanthohumol as a substance of major interest in terms of protection and contributing to factors affecting recovery.

Where does xanthohumol come from?

Xanthohumol is extracted from the female cones of the hop plant, a climbing perennial which is added to beer to improve its taste, aroma, bitterness, frothy texture and preservation.

It's a chalcone-type antioxidant flavonoid, the only one of its kind, which is found solely in hop flowers. It's, therefore, present in beer but in tiny amounts. Due to the high temperatures used in the brewing process, it gets converted into another less powerful compound called isoxanthohumol.

Some very hoppy beers (such as IPAs) contain more, as hops are added after brewing.

The hop has been regarded as a medicinal plant for centuries. Its use dates back to the monasteries of 8th century Europe when it was used for its pharmacological properties, in particular for treating anxiety and sleep problems, as well as its benefits for the endocrine system.

What are Xanthohumol's mechanisms of action?

The xanthohumol supplement's mechanisms of action come from its extraordinarily high content of phenolic compounds. Recent studies show that regular consumption of these compounds can, in the long term, reduce the risk of many chronic health disorders, such as cardiovascular disease.

Phenols, particularly xanthohumol, exert modulatory effects in cells by interacting with a wide range of molecular targets of signaling pathways (mitogen-activated protein kinase, protein kinase C, detoxifying antioxidant enzymes, etc.). These effects translate into an increased expression of certain cytoprotective genes, regulation of the normal cell cycle, inhibition of growth, an increase in apoptosis, inhibition of angiogenesis, as well as suppression of oxidative stress, a state of imbalance which impairs the structural and functional integrity of cell membranes. The role played by oxidative stress in the development of chronic diseases is now widely documented in scientific literature.

Phenolic compounds can also influence the composition of gut microbiota and re-establish intestinal barrier function, thus modulating the chronic inflammation associated with metabolic diseases.

Following ingestion, phenolic compounds, such as xanthohumol, are absorbed, distributed to various tissues and then metabolized by the liver. A proportion undergoes partial conversion by gut flora.

Are there any xanthohumol extract side effects?

Once you’ve identified the best xanthohumol supplement for your needs, you want to make sure it's safe to take. For the most part, xanthohumol supplements are safe to take when consumed by mouth.

It's a popular option for short-term medicinal use with most consumers.

However, there are a few xanthohumol side effects to be aware of.

First, hops can cause dizziness in some people. Additionally, women taking this supplement might notice some changes to their menstrual cycle.

It’s yet to be determined if taking a xanthohumol extract supplement is safe for pregnant women or those who are breastfeeding. To stay on the safe side, it's best to avoid during these times.

Additionally, there are some chemicals in hops that act like estrogen, which can affect people with hormone sensitivities. You shouldn’t take this supplement if you have endometriosis or breast cancer.

Xanthohumol can also cause sleepiness, especially when combined with certain medications and anesthesia during or after surgical procedures. You should stop taking xanthohumol supplements at least two weeks prior to any scheduled surgery.

Daily dose: 3 capsules
Number of doses per pack: 30

Amount per dose

Extract of hop flower standardized to 10% xanthohumol 150 mg
Other ingredients: acacia gum, white rice flour.
Directions for use

Xanthohumol Dosage

We recommend adults take two to three of our xanthohumol capsules a day. If you want to boost its effects on sleep, it's worth knowing that hops act synergistically with other supplements available to buy at Supersmart, such as valerian, found in the natural formulation Advanced Sleep Formula. For improving hormone balance, it's better to combine xanthohumol supplements with an extract of pumpkin seeds.


Cell strengthening: technique that increases our cells' natural defenses against aggressive agents.

Angiogenesis: process whereby new blood vessels grow from existing ones.

Apoptosis: physiological process of programmed cell death.

Free radicals: unstable molecules that seek to bind to other atoms and cause chain reactions.

Procarcinogen: carcinogen precursor that can provoke, aggravate or sensitize cancer or its onset.

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  • Liu M, Hansen PE, Wang G, et al. Pharmacological profile of xanthohumol, a prenylated flavonoid from hops (Humulus lupulus). Molecules. 2015;20(1):754-779. Published 2015 Jan 7. doi:10.3390/molecules20010754
  • Gerhauser C, Alt A, Heiss E, et al. Cancer chemopreventive activity of Xanthohumol, a natural product derived from hop. Mol Cancer Ther. 2002;1(11):959-969.
  • Hirata H, Uto-Kondo H, Ogura M, et al. Xanthohumol, a hop-derived prenylated flavonoid, promotes macrophage reverse cholesterol transport. J Nutr Biochem. 2017;47:29-34. doi:10.1016/j.jnutbio.2017.04.011
  • Lee HJ. Is Advancing Circadian Rhythm the Mechanism of Antidepressants?. Psychiatry Investig. 2019;16(7):479-483. doi:10.30773/pi.2019.06.20
  • Palmieri G, Contaldi P, Fogliame G. Evaluation of effectiveness and safety of a herbal compound in primary insomnia symptoms and sleep disturbances not related to medical or psychiatric causes. Nat Sci Sleep. 2017;9:163-169. Published 2017 May 26. doi:10.2147/NSS.S117770
  • Štulíková K, Karabín M, Nešpor J, Dostálek P. Therapeutic Perspectives of 8-Prenylnaringenin, a Potent Phytoestrogen from Hops. Molecules. 2018;23(3):660. Published 2018 Mar 15. doi:10.3390/molecules23030660
  • Miranda CL, Elias VD, Hay JJ, Choi J, Reed RL, Stevens JF. Xanthohumol improves dysfunctional glucose and lipid metabolism in diet-induced obese C57BL/6J mice. Arch Biochem Biophys. 2016;599:22-30. doi:10.1016/j.abb.2016.03.008
  • Jiang F, Dusting GJ. Natural phenolic compounds as cardiovascular therapeutics: potential role of their antiinflammatory effects. Curr Vasc Pharmacol. 2003;1(2):135-156. doi:10.2174/1570161033476736
  • Liguori I, Russo G, Curcio F, et al. Oxidative stress, aging, and diseases. Clin Interv Aging. 2018;13:757-772. Published 2018 Apr 26.
  • doi:10.2147/CIA.S158513

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    © 1997-2022 Fondation pour le Libre Choix. All rights reserved