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Hesperidin Methyl Chalcone Supplement
Hesperidin Methyl Chalcone Supplement
0725Hesperidin Methyl Chalcone SupplementSize
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Hesperidin Methyl Chalcone
Heart and circulation
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$28.00 In Stock

Hesperidin Methyl Chalcon is an extract of Citrus aurentium standardized to 98%.

  • Improves circulation and helps with certain venous disorders
  • May help with symptoms of venous insufficiency, such as cramps or “heavy legs”
  • Contains antioxidant potency, which may combat free radical damage and the effects of oxidative stress
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Hesperidin Methyl Chalcone Supplement

Our hesperidin methyl chalcone (HMC) supplement is an extract of Citrus aurantium, standardized to 98% and delivered in vegetarian capsules. It supports venous health and improves blood circulation.

What is Hesperidin Methyl Chalcone?

Hesperidin methyl chalcone is a methylated derivative of the flavonoid compound hesperidin. It is found in several fruits, particularly citrus fruits, the majority of which are grown in Spain. The compound takes the form of a pale yellow, slightly bitter, water-soluble powder.

It is widely used in Japan, as well as in Europe both as a nutritional supplement and as an ingredient in cosmetics. It is also available in pharmacies, mainly in combination with other plants, such as butcher's broom, for treating circulation problems.

Hesperidin Methyl Chalcone Benefits

Unlike hesperidin itself, hesperidin methyl chalcone is easily solubilized, facilitating its absorption in the gastrointestinal tract. Like all flavonoids, HMC is a powerful antioxidant, and it’s excellent for optimizing eye health and protecting the cardiovascular system from oxidative attack.

But its primary activity, widely supported by clinical studies, lies in maintaining blood vessel integrity and strengthening the capillary network:

  • With a long history of popular use in Asia, HMC has now made a grand entrance in the United States. Drawing on the many studies conducted on the compound, hesperidin has been formulated into venotropic drugs and nutritional supplements aimed at improving circulation and combatting certain venous disorders.
  • In a short space of time, hesperidin has evolved into an effective treatment for symptoms of venous insufficiency, such as cramps or “heavy legs.”
  • It is used in certain drugs as an effective solution to hemorrhoids, particularly in reducing the frequency of attacks.
  • In addition to its pharmaceutical usage, hesperidin has also proved of interest to the cosmetics industry. This is primarily because of its antioxidant potency, which may combat free radical damage, prevent the effects of oxidative stress and therefore delay cellular aging.
  • Because it helps improve circulation, hesperidin has also been suggested as a skincare ingredient, aimed at easing the sensation of heavy, tired legs and making them feel lighter.

These latter developments suggest that HMC may also play a key role in approaches to age-related disorders — preventing and even treating them. But it is really the compound's overall effects, particularly those related to general circulatory problems, which make such a strong case for supplementing with this very safe product — ideally at a dose of 500–1000 mg a day for 2–3 months.

What do studies show about HMC?

Where is the proof regarding these hesperidin methyl chalcone health benefits? We can find the benefits of hesperidin methyl chalcone in many studies, but there are a few that stand out.

A double-blind, placebo-controlled study of healthy volunteers showed that HMC acts on circulation and vein thrombosis by reducing capillary filtration levels and increasing blood volume. Other research has shown a general improvement in circulation and decreases in viscosity and swelling of the legs.

Together, these properties contribute to cardiovascular health protection, even if the effect is not specific to the components of HMC. A number of compounds, particularly butcher's broom (Ruscus aculeatus) and Vitamin C act synergistically with HMC, significantly boosting its effects.

Similarly, at a conference in San Diego in August 2016, scientists reported considerable progress from combining HMC with DHA (one of the three omega-3 fatty acids the body needs to function properly) and with 90% caffeine-free green tea extract, luteolin and apigenin. This was in the context of evaluating how neurogenesis occurs, the process by which functional neurons are generated from neural stem cells.

Daily dose: 2 capsules
Number of doses per pack: 30

per dose

Extract of Citrus aurentium standardized to 98% hesperidin methyl chalcone 1 000 mg
Other ingredients :Acacia gum.
Directions for use

Hesperidin Methyl Chalcone Dosage

How should you take our HMC supplement? We recommend adults take two capsules daily, one in the morning and one at night, totaling 1000 mg for two to three months. Each capsule contains 500 mg of extract of Citrus aurantium, standardized to 98% HMC.

If you’re looking to utilize hesperidin methyl chalcone in skin care, consider other options. In fact, you can easily find hesperidin methyl chalcone in cosmetics products.

When taken by mouth, the supplement is considered safe for most people to take as long as six months. Safety beyond that time is unknown and HMC should not be taken longer than that.

There are also some hesperidin methyl chalcone side effects to be aware of. The most common side effects of hesperidin methyl chalcone include stomach pain, diarrhea and headaches.

While investigating the various hesperidin methyl chalcone uses, you also want to note some special precautions. If you are pregnant or breastfeeding, you may want to speak to a healthcare professional.

And, because HMC slows blood clotting, it can increase the risk of bleeding. If you have a bleeding disorder, you will want to avoid taking this supplement. It can also lower blood pressure, so if you already have low blood pressure, it may be wise to avoid taking this supplement.

Because this supplement can also interfere with many medications, you will want to talk to your healthcare provider before starting any new regimen if you’re currently taking any.

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  1. Ramelet AA. Clinical benefits of Daflon 500 mg in the most severe stages of chronic venous insufficiency. Angiology. 2001;52 Suppl 1:S49-S56. doi:10.1177/0003319701052001S07
  2. Lee BB, Nicolaides AN, Myers K, et al. Venous hemodynamic changes in lower limb venous disease: the UIP consensus according to scientific evidence. Int Angiol. 2016;35(3):236-352.
  3. Jawien A, Bouskela E, Allaert FA, Nicolaïdes AN. The place of Ruscus extract, hesperidin methyl chalcone, and vitamin C in the management of chronic venous disease. Int Angiol. 2017;36(1):31-41. doi:10.23736/S0392-9590.16.03788-3
  4. Rha CS, Jeong HW, Park S, Lee S, Jung YS, Kim DO. Antioxidative, Anti-Inflammatory, and Anticancer Effects of Purified Flavonol Glycosides and Aglycones in Green Tea. Antioxidants (Basel). 2019;8(8):278. Published 2019 Aug 5. doi:10.3390/antiox8080278

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Hesperidin Methyl Chalcone
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