Hesperidin Methyl Chalcone Supplement
Our hesperidin methyl chalcone (HMC) supplement is an extract of Citrus aurantium, standardized to 98%, and delivered in vegetarian capsules. It supports venous health and improves blood circulation.
What is Hesperidin Methyl Chalcone?
Hesperidin methyl chalcone is a methylated derivative of the flavonoid compound hesperidin. It is found in several fruits, particularly citrus fruits, most of which are grown in Spain. The compound is a pale yellow, slightly bitter, water-soluble powder.
It is widely used in Japan, as well as in Europe, both as a nutritional supplement and as an ingredient in cosmetics. It is also available in pharmacies, mainly in combination with other plants, such as butcher's broom, for treating circulation problems.
Hesperidin Methyl Chalcone Benefits
Unlike hesperidin itself, hesperidin methyl chalcone is easily solubilized, facilitating its absorption in the gastrointestinal tract. Like all flavonoids, HMC is a powerful antioxidant, excellent for optimizing eye health and protecting the cardiovascular system from oxidative attack.
But its primary activity, widely supported by clinical studies, lies in maintaining blood vessel integrity and strengthening the capillary network:
- With a long history of popular use in Asia, HMC has now entered the United States. Drawing on the many studies conducted on the compound, hesperidin has been formulated into venotropic drugs and nutritional supplements aimed at improving circulation and combating certain venous disorders.
- In a short space of time, hesperidin has evolved into an effective treatment for symptoms of venous insufficiencies, such as cramps or “heavy legs.”
- It is used in certain drugs as an effective solution to hemorrhoids, particularly in reducing the frequency of episodes.
- In addition to its pharmaceutical usage, some studies suggest hesperidin may be of interest to the cosmetics industry. This is primarily because of its antioxidant potency, which may combat free radical damage, prevent the effects of oxidative stress, and therefore delay cellular aging.Because it helps improve circulation, hesperidin has also been suggested as a skincare ingredient aimed at easing the sensation of heavy, tired legs and making them feel lighter.
These latter developments suggest that if you buy hesperidin methyl chalcone, it can also play a key role in addressing age-related disorders – preventing and even treating them. But it is really the compound’s overall effects, particularly those related to general circulatory problems, which make such a strong case for supplementing with this very safe product – ideally at a dose of 500 to 1,000 mg a day for 2 to 3 months.
What do studies show about HMC?
Where is the proof regarding these hesperidin methyl chalcone health benefits? We can find the benefits of bitter orange supplements in many studies, but a few stand out.
A double-blind, placebo-controlled study of healthy volunteers showed that when you buy hesperidin methyl chalcone, it acts on circulation and vein thrombosis by reducing capillary filtration levels and increasing blood volume. Other research has shown a general improvement in circulation and decreases in viscosity and swelling of the legs.
Together, these properties contribute to cardiovascular health protection, even if the effect is not specific to the components of HMC. Several compounds, particularly butcher's broom (Ruscus aculeatus) and Vitamin C, act synergistically with HMC, significantly boosting its effects.
Similarly, at a conference in San Diego in August 2016, scientists reported considerable progress from combining HMC with DHA (one of the three omega-3 fatty acids the body needs to function properly) and with 90% caffeine-free green tea extract, luteolin, and apigenin. This was in the context of evaluating how neurogenesis occurs, the process by which functional neurons are generated from neural stem cells.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
|Daily dose: 2 capsules
Number of doses per pack: 30
|Extract of Citrus aurentium standardized to 98% hesperidin methyl chalcone
||1,000 mg |
|Other ingredient: acacia gum. |
Directions for use
How to take these bitter orange capsules?
We recommend adults to take two capsules daily, one in the morning and one at night, totaling 1,000 mg for two to three months. Each bitter orange supplement contains 500 mg of extract of Citrus aurantium, standardized to 98% HMC.
When taken orally, the supplement is considered safe for most people for up to six months. Safety beyond that time is unknown, and HMC should not be taken longer than that.
It is also important to be aware of some potential side effects of hesperidin methyl chalcone. The most common side effects of hesperidin methyl chalcone include stomach pain, diarrhea, and headaches.
While looking into various hesperidin methyl chalcone uses, if you are pregnant or breastfeeding, you may want to speak to a healthcare professional before taking it.
Additionally, since HMC slows blood clotting, it may increase the risk of bleeding. If you have a bleeding disorder, you must avoid this supplement. It can also lower blood pressure, so if you already have low blood pressure, it may be wise to avoid taking this bitter orange extract supplement.
Because this supplement can also interfere with medications you might be taking, you should talk to your healthcare provider before starting any new regimen.
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- Lee BB, Nicolaides AN, Myers K, et al. Venous hemodynamic changes in lower limb venous disease: the UIP consensus according to scientific evidence. Int Angiol. 2016;35(3):236-352.
- Jawien A, Bouskela E, Allaert FA, Nicolaïdes AN. The place of Ruscus extract, hesperidin methyl chalcone, and vitamin C in managing chronic venous disease. Int Angiol. 2017;36(1):31-41. doi:10.23736/S0392-9590.16.03788-3
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