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Immunosenescence: a clinical study reveals a promising avenue

09/09/2026

Immunosenescence is currently one of the major challenges facing longevity research. A recent clinical study appears to have identified a natural compound that may influence certain markers of immune ageing.

✦ Key takeaways Key points from this article
  • Immunosenescence refers to the progressive ageing of the immune system.
  • This phenomenon is now a major focus of health and longevity research.
  • A recent clinical study suggests that urolithin A may improve several markers associated with immune ageing.
  • Urolithin A appears to work, in particular, by supporting the functioning of mitochondria in immune cells.
  • Physical activity, sleep, a balanced gut microbiota and certain nutrients also contribute to the normal functioning of the immune system as we age.

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Study reveals ergothioneine’s unexpected potential for the brain

Found in certain mushrooms, ergothioneine is a compound with antioxidant potential that has caught the attention of researchers studying brain aging. A recent clinical study has explored its effects on memory and sleep.

✦ Key takeaways Key points from this article
  • Ergothioneine is an antioxidant compound found mainly in certain mushrooms and, in smaller quantities, in other foods.
  • The body does not produce it, but the OCTN1/SLC22A4 transporter enables it to be taken up and accumulated in several tissues, including the brain.
  • Researchers are investigating its potential effects on oxidative stress, mitochondria and brain aging.
  • A study involving adults aged 55 to 79 reported encouraging results regarding prospective memory and the ability to fall asleep, though these findings have yet to be confirmed.
  • A balanced diet, sleep, physical activity and mental stimulation remain the key factors in preserving cognitive function.

09/01/2026
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