0
en
US
Free Shipping on Orders Above $25
Free delivery from $25 purchase
× Supersmart Learn by health topic New articles Popular articles Visit our shop My account Smart Prescription Blog Loyalty program Language: English
Anti-aging Features

What is a senescent cell?

A senescent cell is one whose life cycle has come to a permanent end. In the normal scheme of things, such cells are eliminated from the body by the immune system. But in some cases, this fails to happen and they accumulate in tissues, with potentially serious consequences for health.
Elderly, senescent cell no longer able to divide
Once it has become inactive, a senescent cell must be eliminated by the immune system.
Rédaction Supersmart.
2020-06-04Commentaires (0)

The causes of senescence

The process of replicative senescence is naturally initiated in cells as they age. It is triggered by the shortening of telomeres, the DNA sequences found at the tips of chromosomes, which become shorter with each successive DNA replication. After a certain point, this replication of DNA ceases, and the cell stops dividing before dying a natural death. Scientists have recently shown that stress leads to an acceleration in cellular aging by intensifying this telomere-shortening. (1)

There are also external triggers of senescence such as oxidative stress. In a similar way to radiation or UV, oxidative stress damages DNA. Sometimes the cell is able to repair the DNA and ‘restart the machine’, but in other cases, the cell enters senescence in order to be destroyed.

Finally, senescence can be induced by hyperactivation of genes which usually encourage proliferation of cells and therefore cancer. When faced with such hyperactivation, cells respond by entering senescence.

What happens to the senescent cell?

The senescent cell becomes enlarged and flatter, structural changes occur in its chromatin (the ‘framework’ in which DNA is contained), it becomes unreceptive to cell growth and suicide factors … In short, it ensures a permanent end to its activity and multiplication. In addition, the senescent cell secretes pro-inflammatory molecules which summon the immune system responsible for eliminating and destroying dead cells. In this way, senescence and its immune-activating entourage often contribute to inhibiting the development of tumors.

However, in what is a particularly complex molecular process, it can happen that senescence promotes tumor proliferation in the cell’s surrounding environment. The inflammatory molecules secreted by senescent cells may encourage neighbouring cells to convert into pre-cancerous cells and then foster their proliferation. (2)

Note

Research has recently identified the proliferative capacity of senescent cells during embryo development. (3)

The pathological consequences of senescence

Senescence is one of the body’s natural mechanisms of aging and its characteristic markers such as wrinkles or skin slackening. But it is also a cause of certain diseases, as we’ve seen with cancer. The immune system’s failure to destroy senescent cells leads to excessive inflammation and the development of metabolic inflammatory conditions such as obesity and type 2 diabetes.

Senescence is also implicated in arthritis, osteoporosis and atherosclerosis (stiffening of the arteries), as well as in neurodegenerative diseases such as Parkinson’s or Alzheimer’s. (4)

Senolytics, a hopeful option for life expectancy

To maintain good health for as long as possible, the most important recommendation is still to adopt a sensible lifestyle. But particularly promising molecules called senolytics might also play a positive role in the future. (5) An emerging area of anti-aging research for some years now, these compounds could work against senescence and thus slow down the aging process.

Offering potential for preventing the above-mentioned diseases, these senolytics include molecules already present in nature, the most promising of which have been identified as:

They are also available in supplement form (such as Fisetin and Senolytic Complex): an invaluable aid to slowing down the aging process!

References

  1. Herranz, N. & Gil, J. Mechanisms and functions of cellular senescence. J. Clin. Invest. 128, 1238–1246 (2018).
  2. Campisi, J. & d’Adda di Fagagna, F. Cellular senescence: when bad things happen to good cells. Nat. Rev. Mol. Cell Biol. 8, 729–740 (2007).
  3. Storer, M. et al. Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning. Cell 155, 1119–1130 (2013).
  4. Muñoz-Espín, D. & Serrano, M. Cellular senescence: from physiology to pathology. Nat. Rev. Mol. Cell Biol. 15, 482–496 (2014).
  5. Kirkland, J.L., Tchkonia, T., Zhu, Y., Niedernhofer, L.J. and Robbins, P.D. (2017), The Clinical Potential of Senolytic Drugs. J Am Geriatr Soc, 65: 2297-2301.
SharePinterest

Commentaires

You must be connected to your account to leave a comment
Be the first to review this article
Our selection of articles
Oxidative stress caused by free radicals
Oxidative stress: symptoms, causes and protection

Oxidative stress surreptitiously inflicts terrible damage on our cells. Discover the best ways of protecting yourself from the onslaught of free radicals responsible for aging.

Couple eating spermidine-rich foods
Which foods have the highest content of spermidine?

Spermidine is a key substance in our cells, concentrations of which decline with age. Discover the 10 best foods for ensuring a good intake. Which food do you think tops the list?

Young man being vaccinated
Anti-aging: could there soon be a vaccine to slow down aging?

Japanese researchers have succeeded in developing a vaccine that specifically targets senescent cells. Could we soon have an anti-aging vaccine? Let’s take a look.

Kitchen for cooking food
How should different foods be cooked to preserve their vitamins and nutrients?

While the concept of cooking food marked a turning point in the history of mankind by increasing the bioavailability of a lot more nutrients, it can also be responsible for destroying vitamins. Read our advice on the best cooking methods for preserving all your food’s vitamins and nutrients.

Telomerase in chromosomes
Anti-aging: which foods should you eat to activate telomerase?

Telomerase, also known as the ‘immortality enzyme’, is known to hold back aging. How does it work and what should you eat to stimulate its production?

Mitochondria in a cell
Mitochondria: which supplement should you take to take to support them?

Mitochondria (the cells’ power plants) deteriorate with age but you can help take care of yours and slow down the aging process with our tips and natural remedies.

Products which must be of interest

© 1997-2023 Fondation pour le Libre Choix. All rights reserved
© 1997-2023 Fondation pour le Libre Choix. All rights reserved
Nortonx
secure
We use cookies to give you the best online experience. By using this website you agree with our privacy policy I accept cookiesx
Warning
ok