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Plasminogen Activator
Plasminogen Activator
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Plasminogen Activator
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Description

The best natural compounds for cardiovascular health and longevity.

  • Helps unclog the arteries by preventing new plaque from forming and reducing existing deposits.
  • High in nattokinase and d-alpha tocopherol which activate the plasminogen responsible for eliminating blood clots.
  • Contains serrapeptase which helps break down dead cells and the accumulation of damaged tissue.
  • Supports healthy blood flow.
  • Contains high levels of powerful antioxidants (phosphorylated ascorbate, pterostilbene, OPCs...) which help fight cellular aging.
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Plasminogen Activator

Plasmin Supplement for Healthy Blood Vessels

Plasminogen Activator is a superior quality dietary supplement which combines the best natural substances for supporting good cardiovascular health and longevity.

Its carefully-selected compounds help prevent the formation of arterial plaque and reduce existing plaque. Certain of its ingredients, such as nattokinase and d-alpha tocopherol, are even able to directly activate plasminogen, the precursor of plasmin. Plasmin helps break down the fibrin that goes on to form blood clots (1-3). This new formulation has also been developed to promote optimal blood flow.

Plasminogen Activator also contains powerful antioxidant compounds which help protect the body from the harmful effects of oxidative stress, a key factor in cardiovascular problems and aging (4-5).

What exactly is in Plasminogen Activator?

The exceptional Plasminogen Activator contains 6 bioactive ingredients carefully-chosen to act in synergy to protect your arteries:

  1. Nattokinase – This is an enzyme extracted from natto, a Japanese food made of fermented soybeans. By activating plasminogen, nattokinase helps break down fibrin, a substance that circulates in the blood and can build up to the point where it causes a blood clot to form. In addition, nattokinase helps reduce the activity of renin, a compound that increases blood pressure. Nattokinase thus helps both to prevent the formation of clots and reduce hypertension. It also has anti-atherosclerotic properties (6-7);
  2. Serrapeptase – This enzyme, able to break down certain proteins, is used by silkworms to dissolve their cocoons. In the human body, serrapeptase breaks down dead or damaged tissue. It thus helps dissolve plaque, the harmful fibrous layer that builds up on artery walls, and clots, without affecting healthy cells. It also promotes a reduction in swelling by draining fluid that accumulates in tissues (8-10);
  3. Grape seed extract standardized to 95% oligoproanthocyanidins (OPCs) – OPCs are flavonoid polyphenols and particularly effective antioxidants. A number of studies show that OPCs also help maintain the endothelium (the layer of cells lining the interior surface of blood vessels and thus in direct contact with circulating blood) (11-12);
  4. Pterostilbene – Found in grapes and blueberries, this super antioxidant is similar to resveratrol but is even more bioavailable. Pterostilbene helps both to prevent the accumulation of LDL cholesterol and normalize blood pressure. It also has soothing and stress-relieving effects, a significant benefit given that stress is a major factor in the deterioration of arteries and veins (13-14);
  5. Magnesium ascorbyl phosphate – This rare and stable form of vitamin C is 20 times more powerful than standard forms of vitamin C. It helps combat oxidative stress and support collagen production, which plays a role in healthy blood vessel function (15-16);
  6. Vitamin E, in the form of d-alpha tocopherol succinate – Several studies suggest that this natural form of vitamin E activates plasminogen and has a role in cleansing atheromatous deposits from arteries, thus preventing them from narrowing. Vitamin E is also an excellent antioxidant (17-19).

What beneficial effects does Plasminogen Activator have on the arteries?

First, nattokinase, serrapeptase, pterostilbene, and d-alpha tocopherol help prevent and eliminate the atheromatous plaque which progressively clogs up the arteries (20-23). In addition, nattokinase and serrapeptase exert a powerful 'fibrinolytic' effect: they play a part in preventing the formation of blood clots or 'thrombi' (24-25).

Plasminogen Activator's dual action helps reduce the risk of arterial obstruction which can cause serious cardiovascular problems such as myocardial infarction (heart attack), stroke, angina, and sudden ischaemia.

By helping to cleanse the arteries, serrapeptase and d-alpha tocopherol also have a blood-thinning effect (26-27). And nattokinase and pterostilbene help lower blood pressure and reduce hypertension (28-29).

Lastly, as potent antioxidants, ascorbyl magnesium phosphate, OPCs, pterostilbene, and vitamin E combat oxidative stress. Several studies have shown that free radical attack on cells is greatly implicated in the development of cardiovascular disease and aging in general (30-32).

3 additional benefits of this heart-healthy, anti-aging formulation

In addition to these principal benefits:

  • The ascorbyl magnesium phosphate in Plasminogen Activator also supports a robust immunity (33);
  • The nattokinase and serrapeptase may also be able to dissolve amyloid plaques (which can form in the brain and impair cognitive functions) (34);
  • And, according to one study, pterostilbene may help regulate blood sugar levels (35).

Plasmin Capsules' Potential Side Effects

For the vast majority of people, taking this antioxidant supplement is perfectly safe. This plasminogen activator is designed to provide a range of health benefits. However, it is always important to do your own research into the side effects of any supplement you take, and plasmin supplements are no exception.

There is plenty of material online on supplements to unclog arteries and further information on plasminogen function. You can gain access to various research materials, including scientific studies and anecdotal evidence from others who have already added the plasminogen activator supplement to their diets.

If you already take prescription medication, you should speak to your doctor about plasminogen activator function. They will be able to go through your medical history and analyze any medications you might be taking. Adverse drug interactions are rare, but they can happen not only with a plasmin capsule but with any supplement. It is always best to be safe.

Furthermore, if adding plasmin supplements to your diet, make sure you monitor yourself for any plasminogen activator side effects. In the event you experience any unpleasant or uncomfortable side effects, stop taking the plasminogen supplement immediately and speak to your doctor.

Blocked arteries: other natural ways of lowering your risk

There are several additional steps you can take to prevent the development of atheromatous plaque. We know these atheromas are likely to obstruct arteries over time (a process called ‘stenosis’) but they can also become suddenly detached, causing a blood clot, which can itself block the artery, known as 'thrombosis'. To reduce the risk of such cardiac problems, you can try to:

  • Stop smoking;
  • Take regular exercise;
  • Avoid stress whenever possible;
  • Eat a balanced diet (with plenty of fruit and vegetables, as well as minimal salt and fat);
  • Reduce your alcohol intake;
  • Control your hypertension and monitor your cholesterol.

Supplements to take in tandem with Plasminogen Activator

If you are interested in taking other supplements to support your cardiovascular system and circulation, Plasminogen Activator can be combined with a course of Arctic Plankton Oil. This nutritional gem, consisting of a zooplankton-sourced oil, is excellent for the heart. Its high omega-3 content, in particular, will help reduce hypertension, abdominal fat, and cholesterol levels.

And to help you hold back the sands of time, we recommend trying an anti-aging supplement such as Fisetin. Fisetin is an antioxidant flavonoid found at low levels in mangoes, strawberries, and persimmon. This extraordinary natural senolytic promotes the elimination of senescent cells associated with aging. Fisetin is also known for reactivating 'autophagy' – in other words, it helps rid healthy cells of harmful waste products.

Composition
Daily dose: 2 capsules
Number of doses per pack: 30

Amount
per dose

Ascorbyl magnesium phosphate (L-Ascorbic acid 2-phosphate magnesium ester) 300 mg
Nattokinase 200 mg
Serrapeptase (2,200 IU/mg) 200 mg
Grape seed extract standardized to 95% oligo-proanthocyanidins (OPC) 50 mg
Pterostilbene 50 mg
Vitamin E (d-alpha tocopherol succinate) 75 IU
Other ingredients : acacia gum, white rice flour.
Directions for use

How should this supplement be taken?

To benefit from all the positive effects of Plasminogen Activator, you simply need to take two capsules a day with a glass of water.

Make sure you stay within the recommended daily dosage limits. Most instances of side effects occur when people exceed the recommended daily dosage. While side effects remain rare, it is vital to stick to the instructions on the bottle.

As always, take charge of your own health. If you notice anything unusual with the effects of plasmin supplements, schedule an appointment with your primary care provider.

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References
  1. Urano T, Ihara H, Umemura K, et al. The profibrinolytic enzyme subtilisin NAT purified from Bacillus subtilis Cleaves and inactivates plasminogen activator inhibitor type 1. J Biol Chem. 2001;276(27):24690-24696. doi:10.1074/jbc.M101751200
  2. Chen H, McGowan EM, Ren N, et al. Nattokinase: A Promising Alternative in Prevention and Treatment of Cardiovascular Diseases. Biomarker Insights. January 2018. doi:10.1177/1177271918785130
  3. Devaraj S, Chan AV Jr, Jialal I. alpha-Tocopherol supplementation decreases plasminogen activator inhibitor-1 and P-selectin levels in type 2 diabetic patients. Diabetes Care. 2002;25(3):524-529. doi:10.2337/diacare.25.3.524
  4. Elahi MM, Kong YX, Matata BM. Oxidative stress as a mediator of cardiovascular disease. Oxid Med Cell Longev. 2009;2(5):259-269. doi:10.4161/oxim.2.5.9441
  5. Liguori I, Russo G, Curcio F, et al. Oxidative stress, aging, and diseases. Clin Interv Aging. 2018;13:757-772. Published 2018 Apr 26. doi:10.2147/CIA.S158513
  6. Chen H, McGowan EM, Ren N, et al. Nattokinase: A Promising Alternative in Prevention and Treatment of Cardiovascular Diseases. Biomark Insights. 2018;13:1177271918785130. Published 2018 Jul 5. doi:10.1177/1177271918785130
  7. Fujita M, Hong K, Ito Y, Fujii R, Kariya K, Nishimuro S. Thrombolytic effect of nattokinase on a chemically induced thrombosis model in rat. Biol Pharm Bull. 1995;18(10):1387-1391. doi:10.1248/bpb.18.1387
  8. Gupte V, Luthra U. Analytical techniques for serratiopeptidase: A review. J Pharm Anal. 2017;7(4):203-207. doi:10.1016/j.jpha.2017.03.005
  9. Tiwari M. The role of serratiopeptidase in the resolution of inflammation. Asian J Pharm Sci. 2017;12(3):209-215. doi:10.1016/j.ajps.2017.01.003
  10. Kumar SS, Sabu A. Fibrinolytic Enzymes for Thrombolytic Therapy. Adv Exp Med Biol. 2019;1148:345-381. doi:10.1007/978-981-13-7709-9_15
  11. Yamakoshi J, Kataoka S, Koga T, Ariga T. Proanthocyanidin-rich extract from grape seeds attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits. Atherosclerosis. 1999;142(1):139-149. doi:10.1016/s0021-9150(98)00230-5
  12. Bladé C, Arola L, Salvadó MJ. Hypolipidemic effects of proanthocyanidins and their underlying biochemical and molecular mechanisms. Mol Nutr Food Res. 2010;54(1):37-59. doi:10.1002/mnfr.200900476
  13. McCormack D, McFadden D. A review of pterostilbene antioxidant activity and disease modification. Oxid Med Cell Longev. 2013;2013:575482. doi:10.1155/2013/575482
  14. Kosuru R, Kandula V, Rai U, Prakash S, Xia Z, Singh S. Pterostilbene Decreases Cardiac Oxidative Stress and Inflammation via Activation of AMPK/Nrf2/HO-1 Pathway in Fructose-Fed Diabetic Rats. Cardiovasc Drugs Ther. 2018;32(2):147-163. doi:10.1007/s10557-018-6780-3
  15. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to vitamin C and protection of DNA, proteins and lipids from oxidative damage (ID 129, 138, 143, 148), antioxidant function of lutein (ID 146), maintenance of vision (ID 141, 142), collagen formation (ID 130, 131, 136, 137, 149), function of the nervous system (ID 133), function of the immune system (ID 134), function of the immune system during and after extreme physical exercise (ID 144), non‐haem iron absorption (ID 132, 147), energy‐yielding metabolism (ID 135), and relief in case of irritation in the upper respiratory tract (ID 1714, 1715) pursuant to Article 13(1) of Regulation (EC) No 1924/2006 on request from the European Commission. EFSA Journal 2009; 7( 9):1226. [28 pp.].
  16. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to vitamin C and reduction of tiredness and fatigue (ID 139, 2622), contribution to normal psychological functions (ID 140), regeneration of the reduced form of vitamin E (ID 202), contribution to normal energy‐yielding metabolism (ID 2334, 3196), maintenance of the normal function of the immune system (ID 4321) and protection of DNA, proteins and lipids from oxidative damage (ID 3331) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA Journal 2010; 8( 10):1815. [20 pp.]
  17. Tucker JM, Townsend DM. Alpha-tocopherol: roles in prevention and therapy of human disease. Biomed Pharmacother. 2005;59(7):380-387. doi:10.1016/j.biopha.2005.06.005
  18. 18. Verlangieri AJ, Bush MJ. Effects of d-alpha-tocopherol supplementation on experimentally induced primate atherosclerosis. J Am Coll Nutr. 1992;11(2):131-138.
  19. Engin KN. Alpha-tocopherol: looking beyond an antioxidant. Mol Vis. 2009;15:855-860.
  20. Chen H, McGowan EM, Ren N, et al. Nattokinase: A Promising Alternative in Prevention and Treatment of Cardiovascular Diseases. Biomark Insights. 2018;13:1177271918785130. Published 2018 Jul 5. doi:10.1177/1177271918785130
  21. Tiwari M. The role of serratiopeptidase in the resolution of inflammation. Asian J Pharm Sci. 2017;12(3):209-215. doi:10.1016/j.ajps.2017.01.003
  22. McCormack D, McFadden D. A review of pterostilbene antioxidant activity and disease modification. Oxid Med Cell Longev. 2013;2013:575482. doi:10.1155/2013/575482
  23. Tucker JM, Townsend DM. Alpha-tocopherol: roles in prevention and therapy of human disease. Biomed Pharmacother. 2005;59(7):380-387. doi:10.1016/j.biopha.2005.06.005
  24. Fujita M, Hong K, Ito Y, Fujii R, Kariya K, Nishimuro S. Thrombolytic effect of nattokinase on a chemically induced thrombosis model in rat. Biol Pharm Bull. 1995;18(10):1387-1391. doi:10.1248/bpb.18.1387
  25. Tiwari M. The role of serratiopeptidase in the resolution of inflammation. Asian J Pharm Sci. 2017;12(3):209-215. doi:10.1016/j.ajps.2017.01.003
  26. Gupte V, Luthra U. Analytical techniques for serratiopeptidase: A review. J Pharm Anal. 2017;7(4):203-207. doi:10.1016/j.jpha.2017.03.005
  27. Rizvi S, Raza ST, Ahmed F, Ahmad A, Abbas S, Mahdi F. The role of vitamin e in human health and some diseases. Sultan Qaboos Univ Med J. 2014;14(2):e157-e165.
  28. Jensen GS, Lenninger M, Ero MP, Benson KF. Consumption of nattokinase is associated with reduced blood pressure and von Willebrand factor, a cardiovascular risk marker: results from a randomized, double-blind, placebo-controlled, multicenter North American clinical trial. Integr Blood Press Control. 2016;9:95-104. Published 2016 Oct 13. doi:10.2147/IBPC.S99553
  29. Riche DM, Riche KD, Blackshear CT, et al. Pterostilbene on metabolic parameters: a randomized, double-blind, and placebo-controlled trial. Evid Based Complement Alternat Med. 2014;2014:459165. doi:10.1155/2014/459165
  30. Elahi MM, Kong YX, Matata BM. Oxidative stress as a mediator of cardiovascular disease. Oxid Med Cell Longev. 2009;2(5):259-269. doi:10.4161/oxim.2.5.9441
  31. Liguori I, Russo G, Curcio F, et al. Oxidative stress, aging, and diseases. Clin Interv Aging. 2018;13:757-772. Published 2018 Apr 26. doi:10.2147/CIA.S158513
  32. Breitenbach M, Eckl P. Introduction to Oxidative Stress in Biomedical and Biological Research. Biomolecules. 2015;5(2):1169-1177. doi:10.3390/biom5021169
  33. Carr AC, Maggini S. Vitamin C and Immune Function. Nutrients. 2017;9(11):1211. Published 2017 Nov 3. doi:10.3390/nu9111211
  34. Fadl NN, Ahmed HH, Booles HF, Sayed AH. Serrapeptase and nattokinase intervention for relieving Alzheimer's disease pathophysiology in rat model. Hum Exp Toxicol. 2013;32(7):721-735. doi:10.1177/0960327112467040

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