Your cart is empty

Hyaluronic acid supplements: why take them?

Known for its use in cosmetic surgery, hyaluronic acid is first and foremost a major component of the body. What exactly does it do when taken as a supplement?

Hyaluronic acid supplement

What is hyaluronic acid?

First isolated in 1934 by the biochemist Karl Mayer from the vitreous humour of bulls’ eyes, hyaluronic acid, or hyaluronan, is a polysaccharide (complex carbohydrate) naturally present in the human body –and in animal tissues in general (1). More specifically, it’s the product of combining a uronic acid with an aminoglycan.

In humans, it’s an essential component of the extracellular matrix, which provides structural and biochemical support to our cells (2). It’s primarily found in the dermis (the skin layer beneath the epidermis), as well as in the eyes, connective tissue and synovial fluid, the role of which is to reduce friction in the joints (3).

In its pure form, hyaluronic acid has an interesting characteristic: it is not species- or tissue-specific. Its formula is therefore common to all living organisms, which explains its excellent tolerance when injected or taken as a dietary supplement, regardless of its origin (4).

What benefits does hyaluronic acid offer?

A revolution in cosmetic medicine

Hyaluronic acid has been attracting huge attention in the field of cosmetic medicine since it expanded the range of injectable products available, at the end of the 1990s. Completely safe with very few side effects, it is widely acclaimed by practitioners for use in facial contouring or correcting asymmetries (5).

With remarkable viscoelastic and hydrophilic properties, hyaluronic acid is able to retain water, and swells when it comes into contact with it (6). In this way, it fills empty intercellular spaces and provides cohesion to tissues, properties which give the skin a smooth, plumped-up appearance (7). It remains the most widely-used cosmetic facial filler today, having overtaken injectable collagen.

In a less cross-linked (and more fluid) form, hyaluronic acid also features in various minimally-invasive medical-aesthetic facial procedures such as mesotherapy, and more recently, Skinbooster (8). Highly popular for the immediate glow they bring, they also offer increased suppleness and firmness.

A key compound of the joints

Hyaluronic acid’s applications are not restricted to the cosmetic field. The substance is also used within certain types of ophthalmologic or ENT surgery, as well as in rheumatology (9).

In fact, hyaluronic acid is an integral part of cartilage and especially synovial fluid - it alone maintains the latter’s elasticity and viscosity (10-12). Secreted by chondrocytes and synoviocytes, this yellowish fluid cushions friction between moving joints (knees, elbows …). Studies have also highlighted lower concentrations of hyaluronic acid at these sites in subjects suffering from joint problems (13).

A defensive agent

Hyaluronic acid is not an inert component: it is also actively involved in various physiological processes. Indeed, several studies are investigating its role in the mechanism of healing, as well as its interaction with inflammatory mediators and immune cells (particularly in cases of physical trauma) (14).

The best hyaluronic acid supplements

Over time, production of hyaluronic acid tends to decline (15). Depending on the individual, this can manifest in duller or more flaccid skin, morning stiffness or difficulty carrying out daily activities (climbing the stairs, gardening …). It can therefore be helpful to take a supplement, making sure you choose the most suitable formulation for your particular needs.

The form of hyaluronic acid found in the joints has a very high molecular weight (of over 1 million Daltons), hyaluronic acid sodium salt. For a concentrated effect in this area, it’s therefore important to opt for a hyaluronic acid supplement of at least equivalent weight (the vegetarian supplement Hyaluronic Acid, obtained from bacterial fermentation, has a molecular weight of 1.2 million Daltons) (16).

If, however, the objective is beautiful skin, it’s best to choose a low molecular weight supplement: the small molecule size enables it to penetrate deep into skin tissues (thanks to a cutting-edge enzymatic technique, the patented supplement Injuv® Hyaluronic Acid has an unusually low molecular weight, without being in any way chemically altered) (17).

There are also synergistic formulations that combine hyaluronic acid with various plant extracts known for their affinity with the joints, such as Boswellia serrata which helps reduce joint discomfort (in addition to these two compounds, the innovative formulation Flexi-Smart contains standardized avocado soy unsaponifiables which provide a significant amount of phytosterols for maximum efficacy) (18-19).

Le conseil SuperSmart


  1. Walker K, Basehore BM, Goyal A, et al. Hyaluronic Acid. [Updated 2022 Aug 25]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482440/
  2. Amorim S, Reis CA, Reis RL, Pires RA. Extracellular Matrix Mimics Using Hyaluronan-Based Biomaterials. Trends Biotechnol. 2021 Jan;39(1):90-104. doi: 10.1016/j.tibtech.2020.06.003. Epub 2020 Jul 9. PMID: 32654775.
  3. Gupta RC, Lall R, Srivastava A, Sinha A. Hyaluronic Acid: Molecular Mechanisms and Therapeutic Trajectory. Front Vet Sci. 2019 Jun 25;6:192. doi: 10.3389/fvets.2019.00192. PMID: 31294035; PMCID: PMC6603175.
  4. Dai X, Li L, Peterson W, Baumgartner RR, Huang J, Baer-Zwick A, Hoeller S, Ivezic-Schoenfeld Z, Prinz M. Safety and effectiveness of hyaluronic acid dermal filler in correction of moderate-to-severe nasolabial folds in Chinese subjects. Clin Cosmet Investig Dermatol. 2019 Jan 14;12:57-62. doi: 10.2147/CCID.S187079. PMID: 30666143; PMCID: PMC6336025.
  5. Ayatollahi A, Firooz A, Samadi A. Evaluation of safety and efficacy of booster injections of hyaluronic acid in improving the facial skin quality. J Cosmet Dermatol. 2020 Sep;19(9):2267-2272. doi: 10.1111/jocd.13493. Epub 2020 May 30. PMID: 32419355.
  6. Maheu E, Rannou F, Reginster JY. Efficacy and safety of hyaluronic acid in the management of osteoarthritis: Evidence from real-life setting trials and surveys. Semin Arthritis Rheum. 2016 Feb;45(4 Suppl):S28-33. doi : 10.1016/j.semarthrit.2015.11.008. Epub 2015 Dec 2. PMID: 26806183.
  7. Bagga H, Burkhardt D, Sambrook P, March L. Longterm effects of intraarticular hyaluronan on synovial fluid in osteoarthritis of the knee. J Rheumatol. 2006 May;33(5):946-50. PMID: 16652425.
  8. Maheu E, Rannou F, Reginster JY. Efficacy and safety of hyaluronic acid in the management of osteoarthritis: Evidence from real-life setting trials and surveys. Semin Arthritis Rheum. 2016 Feb;45(4 Suppl):S28-33. doi : 10.1016/j.semarthrit.2015.11.008. Epub 2015 Dec 2. PMID: 26806183.
  9. Vincent HK, Percival SS, Conrad BP, Seay AN, Montero C, Vincent KR. Hyaluronic Acid (HA) Viscosupplementation on Synovial Fluid Inflammation in Knee Osteoarthritis: A Pilot Study. Open Orthop J. 2013 Sep 20;7:378-84. doi: 10.2174/1874325001307010378. PMID: 24093052; PMCID: PMC3788189.
  10. Migliore A, Procopio S. Effectiveness and utility of hyaluronic acid in osteoarthritis. Clin Cases Miner Bone Metab. 2015 Jan-Apr;12(1):31-3. doi: 10.11138/ccmbm/2015.12.1.031. PMID: 26136793; PMCID: PMC4469223.
  11. Marinho A, Nunes C, Reis S. Hyaluronic Acid: A Key Ingredient in the Therapy of Inflammation. 2021 Oct 15;11(10):1518. doi: 10.3390/biom11101518. PMID: 34680150; PMCID: PMC8533685.
  12. Hsu TF, Su ZR, Hsieh YH, Wang MF, Oe M, Matsuoka R, Masuda Y. Oral Hyaluronan Relieves Wrinkles and Improves Dry Skin: A 12-Week Double-Blinded, Placebo-Controlled Study. 2021 Jun 28;13(7):2220. doi: 10.3390/nu13072220. PMID: 34203487; PMCID: PMC8308347.
  13. Hermans J, Bierma-Zeinstra SMA, Bos PK, Niesten DD, Verhaar JAN, Reijman M. The effectiveness of high molecular weight hyaluronic acid for knee osteoarthritis in patients in the working age: a randomised controlled trial. BMC Musculoskelet Disord. 2019 May 7;20(1):196. doi: 10.1186/s12891-019-2546-8. PMID: 31064359; PMCID: PMC6503549.
  14. Gariboldi S, Palazzo M, Zanobbio L, Selleri S, Sommariva M, Sfondrini L, Cavicchini S, Balsari A, Rumio C. Low molecular weight hyaluronic acid increases the self-defense of skin epithelium by induction of beta-defensin 2 via TLR2 and TLR4. J Immunol. 2008 Aug 1;181(3):2103-10. doi: 10.4049/jimmunol.181.3.2103. PMID: 18641349.
  15. Kimmatkar N, Thawani V, Hingorani L, Khiyani R. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial. 2003 Jan;10(1):3-7. doi: 10.1078/094471103321648593. PMID: 12622457.
  16. Salehi B, Rescigno A, Dettori T, Calina D, Docea AO, Singh L, Cebeci F, Özçelik B, Bhia M, Dowlati Beirami A, Sharifi-Rad J, Sharopov F, Cho WC, Martins N. Avocado-Soybean Unsaponifiables: A Panoply of Potentialities to Be Exploited. Biomolecules. 2020 Jan 13;10(1):130. doi: 10.3390/biom10010130. PMID: 31940989; PMCID: PMC7023362.



You must be connected to your account to leave a comment

Be the first to review this article

Secure payment
32 Years of experience
Fast Shipping
Free shipping from $25 of purchase