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Bacopa monnieri
Bacopa monnieri
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Bacopa monnieri
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Description

Bacopa monnieri is a nootropic supplement, made from Bacopa leaves.

  • Helps improve memory, learning capacity, and information-processing.
  • Supports central nervous system function.
  • Has a positive effect on the hippocampus.
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Bacopa monnieri plant branch

Bacopa monnieri Supplement – Extract of Bacopa Leaf with Nootropic Properties

Inspired by the sacred practices of Ayurveda, Bacopa monnieri is a nootropic supplement in vegetarian capsules, made from Bacopa leaves and standardized to 20% bacosides (the chemical compounds responsible for its nootropic effects).

It helps improve memory, learning capacity, and information-processing, while at the same time supporting the whole central nervous system in functioning properly. It is often combined with Ginkgo biloba, another 'gold-standard' of Ayurvedic medicine.

Who Should Take Bacopa Monnieri ?

Bacopa monnieri is aimed at many groups of people:

  • Those over 50 who want to combat cognitive decline;
  • Those who frequently experience recall problems and feel as if they are losing their memory;
  • Those wishing to boost their cognitive function;
  • Those looking for a natural-source, traditionally used nootropic;
  • Those with a parent, brother or sister affected by serious cognitive decline.

What Benefits does Bacopa Monnieri Offer?

According to ancient Ayurvedic writings, Bacopa monnieri was recommended for various conditions of the central nervous system and mind: attention deficit, memory problems, chronic stress, decline in cognitive performance, etc. It was used to stimulate awareness and help maintain an alert mind.

Today, research is beginning to confirm such anecdotal use. Many studies, including clinical trials, suggest that extracts of Bacopa monnieri help improve certain cognitive functions and maintain memory (1-3) (retrieval of information (4-5), learning capacity, associative memory (6), visual memory, work memory etc.).

As is the case for almost all Ayurvedic plants, scientists have discovered mechanisms of action that support the claims made for this nootropic

Bacopa monnieri’s mechanisms of action

Bacopa monnieri primarily encourages the formation of synapses (7-9), the junctions between two neurons which ensure that information is transmitted and neural circuits are maintained. All our cognitive abilities depend on these circuits: if they become weak or disappear, our performance declines.

How does Bacopa monnieri do this?

By triggering the production of several molecules central to healthy synaptic function: glutamate and neutrophins such as BDNF and NGF (10-12). These molecules are crucial for initiating the process (13-14). They support the creation of neural circuits (an essential stage in learning), help to maintain existing circuits (vital for preserving memories) and are involved in a cascade of neuromolecular events that support cognitive performance.

Recent double-blind trials showed improvements in cognitive function following supplementation (15-16). Standardized extracts of Bacopa containing at least 20% bacosides (the compounds responsible for the previously mentioned effects) have also produced positive effects on short-term memory in healthy individuals (17-20).

5 Good Reasons to Choose Bacopa Monnieri from SuperSmart

When deciding which Bacopa monnieri supplement to buy, be sure to keep in mind the benefits offered by our product:

  1. Bacopa monnieri is a 100% inspired by ancient practice. Bacopa leaves were traditionally pressed to extract the juice which was then dried into a powder and made into a very sweet syrup in order to mask the bitter taste of the Bacopa. Though inspired by this ancient practice, Bacopa monnieri is a product with neither sugar nor bitterness.
  2. Bacopa monnieri is a leaf extract which contains all the naturally occurring compounds. It is important to remember this as many cheaper supplements are made from the plant’s roots or stems.
  3. The vegetarian capsules contain 100 mg of Bacopa monnieri extract each, standardized to provide at least 20% bacosides.
  4. In India, Bacopa is currently recognized by medical authorities as a valid treatment for several types of mental and intellectual dysfunction.
  5. Bacopa monnieri contains no chemical bulking agents: just Bacopa monnieri leaves.

Additional Measures to make Bacopa Monnieri even more Effective

There are two types of intervention for improving aspects of cognition: taking nootropics such as Bacopa monnieri and brain training (21-23). A large number of studies show that brain training reduces age-related cognitive decline (24-27), and some suggest it is even more effective when combined with Bacopa monnieri supplementation.

The theory behind this potential synergy is quite simple.

Brain training reactivates neural circuits that were previously under-exploited or were in decline (28-30). As we age, many neural circuits disappear or become weaker in areas of the brain important for cognition and memory, such as the hippocampus, the striatum, and the prefrontal cortex (31-32). When brain training is practiced frequently, it repeatedly reactivates these circuits and improves the connection between the neurons of which they are composed (33). As a result, it helps boost or reorganize them more effectively. This reinforcement involves several molecules mentioned earlier in this article: glutamate, BDNF and TGF. Molecules whose production is promoted by Bacopa.

In other words, brain training is the stimulus which signals to the body that it is time to boost its neural circuits. Bacopa is the supplier, providing the elements it needs in order to do so.

It is therefore highly recommended that alongside supplementation with Bacopa monnieri, brain training, such as puzzles, brain teasers and a range of cognitive tasks, is practiced regularly. The aim of this combined approach is to counteract the cognitive losses that lead to decline. It needs to be maintained for at least 12 weeks to be effective.

Bacopa monnieri can also be combined with Ginkgo biloba supplements to increase blood supply to the brain and help maintain cognitive function.

If you are interested in other natural Ayurvedic products available to buy at SuperSmart, you may wish to consider:

  • An extract of Centella asiatica, traditionally used as a psychotropic to relieve mental fatigue.
  • An extract of Boswellia serrata with an anti-inflammatory effect that may benefit the central nervous system.
  • A Tribulus terrestris supplement (Tribulus terrestris), a plant which promotes healthy circulation and is traditionally used for stimulating the libido.

Are there any Precautions to be Taken or Interactions to be Aware of?

As a precautionary measure, Bacopa monnieri is not recommended for women who are pregnant or breastfeeding. Bacopa monnieri can in theory increase the effects of phenothiazine, a neuroleptic drug.

Notes : this product should not be used as a substitute for a varied, balanced diet and a healthy lifestyle. It is important to follow the guidelines on how to take it and the recommended dose, and to use it by the 'best before' date. It is not recommended for women who are pregnant or breastfeeding, or for children under 15. Keep out of children’s reach. Store in a cool, dry place.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Composition
Daily serving: 6 capsules
Number of servings per bottle: 16
Quantity per serving
Bacopa monnieri (leaf extract standardized to provide 20% bacosides) 1500 mg
Other ingredient: acacia gum.

Each vegetarian capsule contains 250 mg of Bacopa monnieri extract standardized to provide at least 20% baccosides.
Directions for use

Adults: Take 1 or 2 capsules, one to three times a day, as required or as advised by your therapist.

Precautions: do not exceed the recommended daily dose. This product is a nutritional supplement and should not be used as a substitute for a varied, balanced diet or a healthy lifestyle. Keep out of children’s reach. Store away from light, heat, and humidity. As with any nutritional supplement, consult a health care practitioner before use if you are pregnant, breastfeeding, or have a medical condition.

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References
  1. S. Aguiar and T. Borowski, Neuropharmacological review of the nootropic herb Bacopa monnieri, Rejuvenation Res 16 (2013), pp. 313-326.
  2. M.P. Pase, J. Kean, J. Sarris, C. Neale, A.B. Scholey and C. Stough, The cognitiveenhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trials, J Altern Complement Med 18 (2012), pp. 647-652.
  3. Russo and F. Borrelli, Bacopa monniera, a reputed nootropic plant: an overview, Phytomedicine 12 (2005), pp. 305-317.
  4. H.C. Barbhaiya, R.P. Desai, K. Pravina, et al., Efficacy and tolerability of BacoMind on memory improvement in elderly participants - a double blind placebo controlled study, J Pharmacol Toxicol 3 (2008), pp. 425-434.
  5. C. Stough, J. Lloyd, J. Clarke, et al., The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects, Psychopharmacology (Berl) 156 (2001), pp. 481-484.
  6. S. Roodenrys, D. Booth, S. Bulzomi, A. Phipps, C. Micallef and J. Smoker, Chronic effects of Brahmi (Bacopa monnieri) on human memory, Neuropsychopharmacology 27 (2002), pp. 279-281.
  7. S.R. Ingole, S.K. Rajput and S.S. Sharma, Cognition enhancers: current strategies and future perspectives, CRIPS 9 (2008), pp. 42-48.
  8. P. Semwal, T. Kapoor, P. Anthwal, B. Sati and A. Thapliyal, Herbal extract as potential modulator and drug for synaptic plasticity and neurodegenerative disorders, Int J Pham Sci Rev Res 25 (2014), pp. 69-79.
  9. C. Stough and M.P. Pase, Improving cognition in the elderly with nutritional supplements, Curr Dir Psychol Sci 24 (2015), pp. 177-183.
  10. J. Preethi, H.K. Singh, P.D. Charles and K.E. Rajan, Participation of microRNA 124- CREB pathway: a parallel memory enhancing mechanism of standardised extract of Bacopa monniera (BESEB CDRI-08), Neurochem Res 37 (2012), pp. 2167-2177.
  11. H. Priyanka, P. Bala, S. Ankisettipalle and S. Thyagarajan, Bacopa monnieri and lDeprenyl Differentially Enhance the Activities of Antioxidant Enzymes and the Expression of Tyrosine Hydroxylase and Nerve Growth Factor via ERK 1/2 and NF- [kappa]B Pathways in the Spleen of Female Wistar Rats, Neurochemical Research 38 (2013), pp. 141-152.
  12. M.P. Mattson, R.B. Lee, M.E. Adams, P.B. Guthrie and S.B. Kater, Interactions between Entorhinal Axons and Target Hippocampal Neurons: A Role for Glutamate in the Development of Hippocampal Circuitry, Neuron 1 (1988), pp. 865-876.
  13. Schmid, S. Hallermann, R. Kittel, et al., Activity-dependent site-specific changes of glutamate receptor composition in vivo, Nat. Neurosci. 11 (2008), pp. 659-666.
  14. M.P. Pase, J. Kean, J. Sarris, C. Neale, A.B. Scholey and C. Stough, The cognitiveenhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trials, J Altern Complement Med 18 (2012), pp. 647-652.
  15. C. Neale, D. Camfield, J. Reay, C. Stough and A. Scholey, Cognitive effects of two nutraceuticals Ginseng and Bacopa benchmarked against modaf.: a review and comparison of effect sizes, Br J Clin Pharmacol 75 (2013), pp. 728-737.
  16. Stough C, Lloyd J, et al. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects.Psychopharmacology (Berl). 2001 Aug;156(4):481-4.
  17. Roodenrys S, Booth D, et al. Chronic effects of Brahmi (Bacopa monnieri) on human memory.Neuropsychopharmacology. 2002 Aug;27(2):279-81.
  18. Examining the nootropic effects of a special extract of Bacopa monniera on human cognitive functioning: 90 day double-blind placebo-controlled randomized trial. Stough C, Downey LA, et al. Phytother Res. 2008 Dec;22(12):1629-34.
  19. Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial. Calabrese C, Gregory WL, et al. J Altern Complement Med. 2008 Jul;14(6):707-13.
  20. C. Hertzog, A.F. Kramer, R.S. Wilson and U. Lindenberger, Enrichment Effects on Adult Cognitive Development: Can the Functional Capacity of Older Adults Be Preserved and Enhanced?, Psychol. Sci. Public Interest 9 (2008), pp. 1-65.
  21. S. Rabipour and A. Raz, Training the brain: fact and fad in cognitive and behavioral remediation, Brain Cogn 79 (2012), pp. 159-179.
  22. Zangara and K.A. Wesnes, Herbal Cognitive Enhancers: New Developments and Challenges for Therapeutic Applications In: M.K. Thakur and S.I.S. Rattan, Editors, Brain Aging and Therapeutic Interventions, Springer Netherlands (2012), pp. 267- 289.
  23. J. Reijnders, C. van Heugten and M. van Boxtel, Cognitive interventions in healthy older adults and people with mild cognitive impairment: a systematic review, Ageing Res Rev 12 (2013), pp. 263-275.
  24. M.E. Kelly, D. Loughrey, B.A. Lawlor, I.H. Robertson, C. Walsh and S. Brennan, The impact of cognitive training and mental stimulation on cognitive and everyday functioning of healthy older adults: a systematic review and meta-analysis, Ageing Res Rev 15 (2014), pp. 28-43.
  25. A.M. Kueider, J.M. Parisi, A.L. Gross and G.W. Rebok, Computerized cognitive training with older adults: a systematic review, PLoS One 7 (2012), p. e40588.
  26. M. Martin, L. Clare, A.M. Altgassen, M.H. Cameron and F. Zehnder, Cognitionbased interventions for healthy older people and people with mild cognitive impairment, Cochrane Database Syst Rev (2011), p. CD006220.
  27. J.A. Anguera, J. Boccanfuso, J.L. Rintoul, et al., Video game training enhances cognitive control in older adults, Nature 501 (2013), pp. 97-101.
  28. K.I. Erickson, S.J. Colcombe, R. Wadhwa, et al., Training-induced plasticity in older adults: effects of training on hemispheric asymmetry, Neurobiol Aging 28 (2007), pp. 272-283.
  29. S. Heinzel, R.C. Lorenz, W.R. Brockhaus, et al., Working memory load-dependent brain response predicts behavioral training gains in older adults, J Neurosci 34 (2014), pp. 1224-1233.
  30. D.L. Dickstein, C.M. Weaver, J.I. Luebke and P.R. Hof, Dendritic spine changes associated with normal aging, Neuroscience 251 (2013), pp. 21-32.
  31. T. Hedden, Imaging Cognition in the Aging Human Brain In: D.R. Riddle, Editor, Brain Aging: Models, Methods, and Mechanisms, CRC Press, Boca Raton (FL) (2007).
  32. K.I. Erickson, S.J. Colcombe, R. Wadhwa, et al., Training-induced plasticity in older adults: effects of training on hemispheric asymmetry, Neurobiol Aging 28 (2007), pp. 272-283.

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