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GHK-Cu Tripeptide
GHK-Cu Tripeptide
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GHK-Cu Tripeptide
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Description

GHK-Cu ‘anti-aging’ reconfigures normal gene expression to resemble those of younger individuals.

  • Small natural peptide with a large therapeutic potential.
  • Offers several biological effects against aging.
  • Modulates expression of around 30% of human genes.
  • Sublingual form used in research.
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60 sublingual tablets
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GHK-Cu Supplement to Help with Aging and Hair Loss

The tripeptide glycyl-histidyl-lysine (GHK) is a small molecule comprising three short chains of amino acids. It is found in biological fluids in either a free form or as a complex formed with the ion Cu2+ (GHK-Cu).

Blood concentration of this molecule is believed to be around 200µg l−1 in people aged 20-25 but after the age of 60, it can fall to 80µg l−1 (23).

Its therapeutic potential is huge: it offers multiple biological effects particularly for anti-aging and skin treatment. Its mechanism of action is based on the reconfiguration of normal gene expression to resemble that of young, healthy individuals.

What are the effects of GHK on aging?

It is now known that aging and its associated diseases are the result of a gradual breakdown in the quality and activity of the human genome (i.e., the complete set of our genes). Over the years, activity of the genes responsible for repairing abnormalities decreases, while that of genes linked to inflammation and destruction of tissues increases (1).

For a long time, scientific research sought to discover the precise mechanism behind this, while in reality, all the data shows there are many mechanisms involved, as well as thousands of genes.

GHK is the perfect solution to this problem since it appears to be able to reconfigure the activity of an incalculable number of genes. Better still, it corrects this activity so that it more closely resembles that of young people.

It thus constitutes a potential advance in preventing and treating conditions typically associated with aging such as cancer, Alzheimer's disease, retinopathy, atherosclerosis, etc.

How Can GHK-CU Tripeptide Help with Hair Loss?

Hair loss is a serious concern for adults everywhere. Hair growth and loss are dictated by complex amino acids and how they interact with each other. Taking a GHK-CU supplement is thought to play a vital role in hair growth by blocking the hormone dihydrotestosterone (DHT).

DHT has been proven to stop hair growth, with the effects becoming more profound with age. Taking a GHK-CU sublingual supplement is highly effective because copper peptides have been clinically proven to prevent the body’s ability to produce this compound by obstructing the enzyme. With a GHK supplement, it is possible to completely block the production of DHT and halt further hair loss.

Deciding to buy GHK-CU goes further than preventing further hair loss. It also stimulates the production of more collagen within the body. Collagen is one of the proteins involved in stimulating hair and nail growth. It is normal for collagen levels to decline with age, but by choosing a GHK-CU peptide for sale, the effects are halted and reversed.

Regularly taking these amino acid supplements support the body by leveraging the body’s own natural production to fabricate more hair and prevent further loss in time.

Increased collagen production also supports scalp health and assists with the regeneration of hair. Anyone concerned with thinning hair or a receding hairline can stop the problem in its tracks with these anti-aging supplements.

Benefits to the Skin

GHK-CU tripeptide compounds are naturally produced by the body. These copper complexes can be found in several locations, including within saliva and urine. Studies have shown that it plays an essential role in skin biology by attracting immune cells, containing antioxidant effects, fighting inflammation, stimulating collagen, and promoting wound healing.

Unfortunately, the concentrations of GHK-CU within the body decline with age. Taking a GHK-CU supplement regularly supports the body in maintaining its required levels of this copper complex.

Some of the benefits of this supplement for the skin include:

  • Tighten loose skin
  • Reverse the thinning of aged skin
  • Improve firmness
  • Bolster elasticity and strength
  • Reduce the characteristic signs of aging, such as wrinkles and fine lines
  • Smooth skin to improve clarity
  • Improve overall skin appearance
  • Reduce inflammation

The GHK-CU sublingual supplement acts as a support system for countering the common signs of aging. Enjoying GHK peptide benefits, however, requires a healthy diet and regular exercise to properly provide the body’s largest organ with what it needs to flourish.

Does it Help Reduce Pain?

Animal studies have shown that taking a GHK-CU tripeptide can reduce pain. GHK-CU is a compound that acts as an anti-inflammatory, meaning that people who suffer from serious conditions that lead to pain could experience relief by taking this supplement.

Another of the GHK-CU benefits is that it can promote wound healing. It does this by raising the concentration of antioxidant enzyme levels in the body. In turn, this speeds up tissue growth. These powerful wound healing benefits can allow for faster recovery, regardless of age.

Anyone over the age of 35 will stand to gain the most from taking a GHK-CU supplement because this is when the body’s ability to heal wounds naturally begins to decrease. Adults who reach their mid-to-late 30s tend to take longer to recover from minor cuts, scrapes, and bruises.

GHK-CU is a safe and scientifically proven method of encouraging the body to heal itself faster. While it cannot cure all forms of pain, it can support the body’s natural processes of self-healing.

Can it Boost Cognitive Abilities?

Cognitive ability is another bodily function that declines with age. Many people are rightly worried over their brain health as they age, particularly due to the risk of diseases like Alzheimer’s and dementia.

Aging and brain disorders can be fought with GHK-CU. Scientists have discovered that GHK-CU prevents cognitive dysfunction by reducing the levels of an abnormal compound known as amyloid beta. Its ability to raise the number of antioxidant enzymes within the body and fight off oxygen-derived free radicals are other reasons why it has been highlighted as such an effective way of preserving brain health.

Moreover, GHK-CU can also reduce the rate of cognitive decline related to age by improving the function of the nervous system. This copper complex plays an essential role in encouraging the development of blood vessels and new nerves.

In one emerging animal study conducted on young chicks, the compound was shown to induce the formation of new brain neurons. Enhancing the neural pathways throughout the mind can prevent memory loss and improve recall as years pass.

While studies into GHK-CU’s impact on brain health are relatively recent, initial indicators have demonstrated impressive effects. Opting for a GHK-CU sublingual supplement could be the key to future cognitive health.

Are there Any GHK-CU Side Effects?

Before adding any new supplement, it is crucial to carry out in-depth, independent research into any potential side effects. Generally, GHK-CU is safe to consume, with any reported GHK-CU side effects being mild at best and relatively rare.

Documenting known instances of side effects from the supplement is vital because if any side effects are experienced while taking these supplements, you know what to be aware of.

First, side effects tend to happen in most cases when the recommended daily dosage has been exceeded. Always follow the instructions on the package to avoid increasing the risk of any uncomfortable or unpleasant effects.

Second, there are some cases when taking a supplement could interfere with prescription medication. Anyone who has been prescribed medication for an acute or chronic condition should contact their medical professional.

Only a doctor can review your medical history to determine whether taking a GHK-CU supplement could cause an adverse effect.

In the event that any unexpected side effects are experienced, stop taking the supplement immediately and get in touch with a recognized health professional. They will be able to examine the supplement and run tests to determine why side effects may have surfaced.

On the whole, the GHK-CU consumer supplement is largely safe, with plenty of scientific studies performed to verify the veracity of the health claims made. What matters is responsible supplement usage. Monitor the effects of the supplement and take action if any side effects occur.

Composition
Copper-peptide glycy-histidyl-lysine complex (GHK) 5 mg
Other ingredients : sorbitol, xylitol, stearic acid, peppermint flavoring, stevia extract .
Directions for use

How Should I Take GHK-CU Sublingual Capsules?

GHK-CU is available in a variety of forms, including via injectables. Sublingual capsules are designed to be taken orally.

Follow the dosage on the bottle and place the capsule underneath the tongue. While it is underneath your tongue, allow it to dissolve. It should take no more than 30 seconds for the entire capsule to dissolve. Do not attempt to swallow or chew it.

The reason why it must be placed under the tongue is because of the high concentration of blood vessels under the tongue. These support the easy, direct absorption of GHK-CU into the bloodstream, whereas oral tablets would take longer to work because they would need to be processed by the digestive system first.

Unlike ordinary oral tablets, there is no need to be concerned about taking this supplement on an empty or full stomach. These supplements completely bypass the digestive system and flow directly into the bloodstream.

Be aware that you should still avoid taking this supplement with food to avoid it coming into contact with any remains in your mouth. Rinse out your mouth before placing the capsule underneath the tongue.

Avoid consuming anything more than the recommended daily dosage. While not a dangerous supplement, the risk of side effects is enhanced by exceeding the recommended dosage in an attempt to enhance the effects.

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4 /5 4 reviews
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Reviews 4
Excellent
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25%

CHADWICK Melinda
5
Seems to have a mood lifting effect.
MATUSZAK Sussn
5
It is helping my skin
Skye Jones
5
I really liked this product, I used it in conjunction with epitalon and my skin was really good. I haven’t used it on its own though - I bought it a second time because I liked the results the first time but as said I used it with epitalon at the same time
Customer
1
There seemed to be an error in formulation. This is an amazing peptide but supersmart's version was flawed. 3 people I know experienced anxiety, headaches, paresthesias. My fiance went to the ER due to these symptoms. I shouldn't have trusted such a sketchy company when they lowered their price on this product 70%. They obviously knew the formulation was bad but chose to liquidate inventory on customers. I'll never buy another product from supersmart
References
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  3. H. R. Choi, Y. A. Kang, S. J. Ryoo et al., “Stem cell recovering effect of copper-free GHK in skin,” Journal of Peptide Science, vol. 18, Article ID 685G690, pp. 685-690, 2012.
  4. S. Jose, M. L. Hughbanks, B. Y. Binder, G. C. Ingavle, and J. K. Leach, “Enhanced trophic factor secretion by mesenchymal stem/stromal cells with Glycine-Histidine-Lysine (GHK)- modified alginate hydrogels,” Acta Biomaterialia, vol. 10, pp. 1955-1964, 2014
  5. L. Pickart, J. M. Vasquez-Soltero, F. D. Pickart, and J. Majnarich, “GHK, the human skin remodeling peptide, induces anti-cancer expression of numerous caspase, growth regulatory, and DNA repair genes,” Journal of Analytical Oncology, vol. 3, no. 2, pp. 79-87, 2014.
  6. K. Yano, J. S. Grove, R. Chen, B. L. Rodriguez, J. D. Curb, and R. P. Tracy, “Plasma fibrinogen as a predictor of total and cause-specific mortality in elderly Japanese-American men,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 21, no. 6, pp. 1065-1070, 2001.
  7. M. Benderly, E. Graff, H. Reicher-Reiss, S. Behar, D. Brunner, and U. Goldbourt, “Fibrinogen is a predictor of mortality in coronary heart disease patients,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 16, no. 3, pp. 351-356, 1996.
  8. C. L. Carty, P. Heagerty, S. R. Heckbert et al., “Interaction between fibrinogen and IL-6 genetic variants and associations with cardiovascular disease risk in the cardiovascular health study,” Annals of Human Genetics, vol. 74, no. 1, pp. 1-10, 2010.
  9. N. R. Jana, “Protein homeostasis and aging: role of ubiquitin protein ligases,” Neurochemistry International, vol. 60, no. 5, pp. 443-447, 2012.
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  11. N. Chondrogianni, M. Sakellari, M. Lefaki, N. Papaevgeniou, and E. S. Gonos, “Proteasome activation delays aging in vitro and in vivo,” Free Radical Biology & Medicine C, vol. 71, pp. 303- 320, 2014.
  12. P. J. Hohensinner, J. J. Goronzy, and C. M. Weyand, “Targets of immune regeneration in rheumatoid arthritis,” Mayo Clinic Proceedings, vol. 89, no. 4, pp. 563-575, 2014.
  13. B. Debrabant, M. Soerensen, F. Flachsbart et al., “Human longevity and variation in DNA damage response and repair: study of the contribution of sub-processes using competitive gene-set analysis,” European Journal of Human Genetics, vol. 22, no. 9, pp. 1131-1136, 2014.
  14. I. S. Young and J. V. Woodside, “Antioxidants in health and disease,” Journal of Clinical Pathology, vol. 54, no. 3, pp. 176-186, 2001.
  15. Y. Hong, T. Downey, K. W. Eu, P. K. Koh, and P. Y. Cheah, “A ‘metastasis-prone’ signature for early-stage mismatch-repair proficient sporadic colorectal cancer patients and its implications for possible therapeutics,” Clinical and Experimental Metastasis, vol. 27, no. 2, pp. 83-90, 2010
  16. P. V. Peplow and G. D. Baxter, “Gene expression and release of growth factors during delayed wound healing: A review of studies in diabetic animals and possible combined laser phototherapy and growth factor treatment to enhance healing,” Photomedicine and Laser Surgery, vol. 30, no. 11, pp. 617-636, 2012.
  17. K. Deonarine, M. C. Panelli, M. E. Stashower et al., “Gene expression profiling of cutaneous wound healing,” Journal of Translational Medicine, vol. 5, article 11, 2007.
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  19. T. Arodz, D. Bonchev, and R. F. Diegelmann, “A network approach to wound healing,” Advances in Wound Care, vol. 2, no. 9, pp. 499-509, 2013.
  20. Schlesinger D.H., Pickart L., Thaler M.M. Growth-modulating serum tripeptide is glycyl-histidyl-lysine. Experientia. 1977;33:324-325. doi: 10.1007/BF02002806
  21. P. Li, H. M. Nielsen, and A. Mullertz, “Oral delivery of peptides ¨ and proteins using lipid-based drug delivery systems,” Expert Opinion on Drug Delivery, vol. 9, no. 10, pp. 1289-1304, 2012.
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  23. Loren Pickart et al. The Human Tripeptide GHK-Cu in Prevention of Oxidative Stress and Degenerative Conditions of Aging: Implications for Cognitive Health, Oxid

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