Urolithin A is a dietary supplement containing urolithin A, a metabolite studied in the fields of cellular health and anti-aging.
This particularly innovative ingredient is attracting scientific interest because of its potential effects on mitochondrial and cellular function, and thus its ability to maintain young-looking skin and support overall longevity, etc. (1)
The supplement Urolithin A is part of our longevity product category.
Definition and benefits of urolithin A, a new ‘anti-aging’ ingredient
What exactly is urolithin A?
Urolithin A is a metabolite produced naturally by the body from the conversion by gut bacteria of dietary ellagitannins and ellagic acid (it is often described as a postbiotic).
Ellagitannins and ellagic acid are found at low levels in fruits such as pomegranates, blackberries, nuts...
Promising health benefits of urolithin A
Urolithin A has been the subject of numerous studies investigating its potential to support:
- cellular health and longevity, by increasing mitophagy (namely the recycling of dysfunctional and/or senescent mitochondria), maintaining mitochondrial function and reducing harmful inflammation (2);
- the health and appearance of the skin, by increasing expression of type 1 collagen and exerting antioxidant effects (3);
- joint health, by reducing cartilage degeneration and synovial inflammation (4);
- brain health, by promoting blood-brain barrier permeability (5);
- muscle health, by supporting strength and recovery (6);
- and health and longevity in general (7-8).
As a reminder, mitochondria are responsible for producing ATP, the primary source of cellular energy which the body needs to function properly and survive.
Mitochondrial dysfunction plays a key role in the aging process and subsequent development of age-related health problems (metabolic, degenerative...)
What are the benefits offered by urolithin A supplementation?
Taking a pure urolithin A supplement enables you to:
- easily and effectively increase the amount of urolithin A in your body;
- and to do so by side-stepping the stage of converting ellagitannins and ellagic acid into urolithin A in the gut. Indeed, this stage is not possible for everyone, as it is directly related to the individual health and composition of the gut microbiome. Moreover, the body’s natural ability to produce urolithin A from its precursors declines with age. This conversion process is therefore variable and is only possible in around 40% of older populations.
Six strengths of our urolithin A product
Our urolithin A supplement stands out from other ‘anti-aging’ and similar products in 6 key facets:
- its exclusive and innovative aspect: urolithin A is growing in popularity in the United States ;
- its unique performance: the results produced by urolithin A studies are some of the most promising in current anti-aging research (9);
- its high but safe dose: our product provides at least 500mg urolithin A a day, a dose studies have shown to be effective and safe;
- its natural source: it contains only urolithin A obtained from pomegranate extract;
- its proven high quality: the metabolite obtained is rigorously tested to ensure optimal purity;
- its natural excipients: only acacia gum and white rice flour are used in our product, 100 % natural excipients which contribute to the supplement’s consistency and stability.
WARNINGS
Do not exceed the recommended daily dose. This product is a nutritional supplement and should not be used as a substitute for a varied and balanced diet or a healthy lifestyle.
STORAGE
Store in a cool, dry place away from direct sunlight, heat, and humidity.
Keep out of reach of children.
PREGNANCY AND MEDICAL CONDITIONS
If you are pregnant, breastfeeding, or have any medical conditions, consult your healthcare provider before using this product.
SUPPLEMENT INTERACTIONS
Consult your healthcare provider before use, especially if you are taking any medications or other supplements as there may be potential interactions.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Daily dose: 2 capsules
Number of doses per pack: 30
| Amount per dose |
Urolithin A
| 500 mg |
Other ingredients : acacia gum, white rice flour.
|
take 2 capsules a day with food. Each capsule provides 250mg of urolithin A.
30 days.
store away from heat, light and humidity.
for adults. Do not exceed the recommended daily amount. This product is a nutritional supplement which should not be used as a substitute for a varied, balanced diet or healthy lifestyle. Keep out of young children’s reach. Store away from light, heat and humidity. As with all nutritional supplements, consult a health professional before taking if you are pregnant, breastfeeding or have a health condition.
- Kothe B, Klein S, Petrosky SN. Urolithin A as a Potential Agent for Prevention of Age-Related Disease: A Scoping Review. Cureus. 2023 Jul 27;15(7):e42550. doi: 10.7759/cureus.42550. PMID: 37637627; PMCID: PMC10460156.
- Kothe B, Klein S, Petrosky SN. Urolithin A as a Potential Agent for Prevention of Age-Related Disease: A Scoping Review. Cureus. 2023 Jul 27;15(7):e42550. doi: 10.7759/cureus.42550. PMID: 37637627; PMCID: PMC10460156.
- Liu CF, Li XL, Zhang ZL, Qiu L, Ding SX, Xue JX, Zhao GP, Li J. Antiaging Effects of Urolithin A on Replicative Senescent Human Skin Fibroblasts. Rejuvenation Res. 2019 Jun;22(3):191-200. doi: 10.1089/rej.2018.2066. Epub 2018 Oct 25. PMID: 30215291.
- Kothe B, Klein S, Petrosky SN. Urolithin A as a Potential Agent for Prevention of Age-Related Disease: A Scoping Review. Cureus. 2023 Jul 27;15(7):e42550. doi: 10.7759/cureus.42550. PMID: 37637627; PMCID: PMC10460156.
- An L, Lu Q, Wang K, Wang Y. Urolithins: A Prospective Alternative against Brain Aging. Nutrients. 2023 Sep 6;15(18):3884. doi: 10.3390/nu15183884. PMID: 37764668; PMCID: PMC10534540.
- Kothe B, Klein S, Petrosky SN. Urolithin A as a Potential Agent for Prevention of Age-Related Disease: A Scoping Review. Cureus. 2023 Jul 27;15(7):e42550. doi: 10.7759/cureus.42550. PMID: 37637627; PMCID: PMC10460156.
- Kothe B, Klein S, Petrosky SN. Urolithin A as a Potential Agent for Prevention of Age-Related Disease: A Scoping Review. Cureus. 2023 Jul 27;15(7):e42550. doi: 10.7759/cureus.42550. PMID: 37637627; PMCID: PMC10460156.
- Kothe B, Klein S, Petrosky SN. Urolithin A as a Potential Agent for Prevention of Age-Related Disease: A Scoping Review. Cureus. 2023 Jul 27;15(7):e42550. doi: 10.7759/cureus.42550. PMID: 37637627; PMCID: PMC10460156.
- Kothe B, Klein S, Petrosky SN. Urolithin A as a Potential Agent for Prevention of Age-Related Disease: A Scoping Review. Cureus. 2023 Jul 27;15(7):e42550. doi: 10.7759/cureus.42550. PMID: 37637627; PMCID: PMC10460156.
- Kothe B, Klein S, Petrosky SN. Urolithin A as a Potential Agent for Prevention of Age-Related Disease: A Scoping Review. Cureus. 2023 Jul 27;15(7):e42550. doi: 10.7759/cureus.42550. PMID: 37637627; PMCID: PMC10460156.
- Heber D. Pomegranate Ellagitannins. In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 10. Available from: https://www.ncbi.nlm.nih.gov/books/NBK92772/