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Senolytic Complex Supplement
Senolytic Complex Supplement
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Senolytic Complex
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Description

Senolytic Complex is designed to destroy the senescent cells responsible for aging.

  • Has a rapid and long-lasting rejuvenating effect on the whole body
  • Encourages self-destruction of the senescent cells responsible for aging and age-related health issues (muscle weakness, cognitive decline, cardiovascular problems, chronic inflammation, etc.)
  • Rich in fisetin, one of the most powerful natural senolytic compounds
  • Contains quercetin phytosome, which is 20 times more absorbable than standard quercetin
  • Draws on the very latest scientific research
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Senescent cell under a target mark

Senolytic Complex - Supplement Supplement with Quercetin Phytosome

Senolytic Complex is a completely new senolytic supplement that fights the aging process, based on the very latest discoveries in anti-aging medicine, now available to buy at Supersmart.

The term “senolytic,” recently coined by the scientific community, describes the ability to eliminate senescent cells (i.e. aged cells), the presence of which has been identified in recent years as being, along with oxidative stress and telomere shortening, one of the causes of aging. Since there was previously no way of combating this process, senolytic supplements constitute a truly revolutionary discovery.

Our formulation contains the most powerful, natural, senolytic compounds identified to date: quercetin phytosome, theaflavin, and most importantly, fisetin, an extraordinary flavonoid that’s gaining recognition in the scientific community.

Who should consider taking Senolytic Complex?

Generally, Senolytic Complex is made for anyone over the age of 40, looking for a way to combat the creation of senescent cells. It is particularly recommended for anyone looking to maintain good physical condition and optimal health as they age, as well as anyone who’s already experiencing age-related problems, including muscle and joint weakness, heart problems, vision and hearing impairments, cognitive decline, as well as anyone who’s interested in reducing their risk of developing them.

How do senolytic compounds work?

The Invasion of Senescent Cells

In 2014, researchers achieved a major accomplishment in the fight against aging. They identified old, worn-out cells in the tissues of subjects aged over 40. Termed “senescent cells,” these zombie-like cells are deformed and unable to divide and are distributed throughout the body’s tissues. Even though they’re no longer functioning normally, they’re also not eliminated and accumulate pathologically.

The development of these cells is rare in young people but the odds of them developing increases with age, particularly in adipose tissue, skeletal muscle, blood vessels, the brain, kidneys and skin.

How They Affect Healthy Cells

Unfortunately, senescent cells do not just take over, they also impede the activity of neighboring healthy cells by continually releasing pro-inflammatory cytokines (IL-1, IL-6 and IL-8), vesicles and insoluble proteins (fibronectin, collagen) into the extracellular environment. These substances are really distress calls: they signal to other cells the advanced state of deterioration in which they find themselves, but at the same time, they significantly affect the function of neighboring healthy cells.

Over the last three years, a number of studies have shown that the level of senescent cells in the body is directly linked to the pace of aging, when the risk of developing age-related health problems is higher.

Combating Senescent Cells

These cells normally destroy themselves in a process called apoptosis in order to avoid damaging the body. However, this mechanism does not always work, in which case the senescent cells continue to parasitize the body and potentially cause harm.

Fortunately, researchers have identified several compounds that aid the repair of this defective mechanism, potentially bringing about the self-destruction of these senescent cells. These extraordinary compounds are called senolytics.

The first study to identify senolytics was published in 2015. Quercetin, a natural flavonoid compound, was found to dramatically decrease both the number of senescent cells and secretion of pro-inflammatory factors in the organism studied.

Dozens of studies have since identified natural compounds with the same properties. This has led to the development of a revolutionary new therapy, senolytic therapy, which is able to selectively destroy senescent cells and potentially reduce the severity of age-related health problems and increase the body’s resilience and longevity. And those are just some of the quercetin phytosome benefits.

Senolytic therapy is essentially a massive spring cleaning, after which healthy cells regain control of the body and again function at full capacity. It represents a significant advance in the fight against aging.

What is in Senolytic Complex?

Senolytic Complex contains three exceptional senolytic compounds (fisetin, quercetin and theaflavin) and three other anti-aging compounds (Vitamin C, nicotinamide mononucleotide and bromelain).

Fisetin

Fisetin is part of the large family of flavonoids, a group of polyphenol antioxidants found in small amounts in strawberries, mangos and certain types of plants. Of all the flavonoids that have been tested, it has shown to be the most effective at reducing the number of senescent cells.

Its hydrophobic nature means it penetrates cells easily via cell membranes and subsequently promotes the self-destruction of abnormal cells (such as senescent cells) by activating specific proteins.

One of its abilities includes reducing the fraction of senescent cells in the immune system (T lymphocytes and NK cells), which increases its beneficial effects since immune cells are also important for clearing out senescent cells. In addition, it inhibits the activity of several inflammatory cytokines such as TNFα, IL-6, and the transcription factor NF-Κb, and it may even help lower fat levels in the blood.

Quercetin and Theaflavin

Since senescent cells use different mechanisms to resist programmed cell death, it’s important that other senolytic compounds are included in the formulation. In our senolytic supplement formula, quercetin phytosome and theaflavin are those two senolytic compounds.

Quercetin, like fisetin, is a member of the flavonoid family. The Quercefit® in Senolytic Complex is extracted from Styphnolobium japonicum, the Japanese pagoda tree or “honey tree.”

So what is quercetin phytosome? It’s essentially quercetin delivered in a phytosome form which maximizes its absorption into the bloodstream. In fact, a comparison of quercetin phytosome vs quercetin shows that quercetin phytosome is 20 times more bioavailable than standard quercetin.

But what is quercetin phytosome used for? In combination with theaflavin, a polyphenol from black tea, these benchmark senolytic are also designed to destroy senescent cells, just like fisetin.

Bromelain, NMN and Vitamin C

Our senolytic supplement is enhanced by the addition of anti-aging substances that work in symbioses, such as nicotinamide mononucleotide, an element essential for cellular energy production and longevity of sirtuin proteins, bromelain, an enzyme which actively opposes systemic inflammation, and Vitamin C (in its non-acid form), a potent antioxidant that supports the immune system.

Quercetin Phytosome Side Effects

Now that you understand the difference between quercetin vs quercetin phytosome, you are ready to use senolytic supplements for optimal well-being. But, before you take a senolytic supplement, you need to know more than fisetin or quercetin phytosome’s uses; you also need to know potential side effects.

For most people, it is completely safe to take quercetin phytosome supplements. However, you may be taking a medication or have a health condition that could interact with them. That’s why you should always discuss new supplement regimens with your healthcare provider. If you begin taking a new supplement and notice any side effects, stop using immediately and speak with your practitioner.

Additionally, pregnant women and nursing mothers should use extra caution when taking supplements. Until more research is performed, it’s best to avoid any new substances that you don’t need to take.

And please note that fisetin senolytic supplements should not be taken in conjunction with antivitamin K drugs, which are commonly used oral anticoagulants.

Composition
Daily dose: 3 capsules
Number of doses per pack: 30
Amount per dose
Quercefit® (Complex of phytosomes of sunflower and Sophora japonica quercetin standardized to 40% lecithin and 40% quercetin) 400 mg
Bromelain 2000 GDU/g 200 mg
Vitamin C (Ester C®) 100 mg*
Fisetin from Rhus succedanea stem 100 mg
Extract of decaffeinated black tea leaves 300 mg
Nicotinamide mononucleotide 10 mg
Other ingredients: acacia gum, white rice flour.
*125% of RDA for Vitamin C
Quercefit®, Indena, Italy. Ester C®, Ester C Company.
Directions for use

How and When to Take Quercetin Phytosome

A senolytic supplement can either be taken intermittently or taken continuously, according to your needs. For best results, we recommend taking three capsules a day. Take each capsule with a meal.

In terms of how this senolytic therapy works over time, think of it as three steps:

  1. Eliminate senescent cells from your body with the aid of Senolytic Complex.
  2. Prevent the development of new senescent cells by improving your lifestyle, protecting yourself against the factors that cause cellular aging, and strengthening both your DNA repair systems (with the aid of DNA Repair) and antioxidant systems (with the aid of Resveratrol synergy). With its Vitamin C and bromelain, Senolytic Complex plays an active role in inhibiting the reappearance of senescent cells. A number of mechanisms are responsible for their development, but two appear to be dominant: high inflammation levels and oxidative stress.
  3. Stimulate and boost the immune system so that it too can help clear out senescent cells (with the aid of an immunostimulant mushroom extract).

You should never exceed the recommended amount of any supplement and don’t use it if the outer seal is broken. Additionally, keep all medications and supplements out of the reach of children or pets.

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Daphne A. Holman
5
This is an amazing product. I have been taking it for about 2 months or more. I feel better in so many ways. I have less pain. I feel sharper, more of a clear mind.
References
  1. Ovadya Y, Krizhanovsky V. Senescent cells: SASPected drivers of age-related pathologies. Biogerontology. 2014;15(6):627-642. doi:10.1007/s10522-014-9529-9
  2. van Deursen JM. The role of senescent cells in ageing. Nature. 2014;509(7501):439-446. doi:10.1038/nature13193
  3. Zhu Y, Tchkonia T, Pirtskhalava T, et al. The Achilles' heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell. 2015;14(4):644-658. doi:10.1111/acel.12344

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