S-Acetyl Glutathione Supplement for Supporting Overall Health

S-acetyl glutathione (SAG) is a new and superior alternative to reduced glutathione, with better absorption in the body and several antioxidant benefits.

What is Glutathione?

Reduced glutathione, commonly known as glutathione or GSH, is a tripeptide made up of L-glutamine, L-cysteine, and glycine. It is ubiquitous in all living systems. However, chronic oxidative stress reduces cellular glutathione levels, and its biosynthesis is affected by dietary and individual biological factors – a person's particular ability to metabolize its various precursors.

Glutathione is the most important intracellular antioxidant produced by the human body. Until now, taking it orally at high doses or sublingually was necessary to ensure maximum absorption. In fact, most of an oral glutathione dose becomes oxidized before cells can absorb and utilize it.

What are the benefits associated with S-acetyl Glutathione capsules?

In this form, glutathione's essential properties are preserved and enhanced, enabling it to:

• Play a role in boosting mitochondrial energy production and function. Mitochondria, the energy-producing powerhouses of cells, are also the primary intracellular site of oxygen consumption and source of reactive oxygen species (ROS). SAG has been shown to cross the membrane of the mitochondria, increasing the organelle's activity and minimizing the generation of ROS, thus helping to maintain mitochondrial integrity and overall health.
• Ensure protection against DNA damage. It eliminates heavy metals (mercury, lead, cadmium…) as well as organic toxins, while maintaining blood levels of magnesium. SAG is a simpler and equally effective alternative to intravenous chelation, which was previously considered the most active way of administering glutathione.
• Protect against certain chronic diseases (herpes, HIV, Lyme disease, fibromyalgia, chronic candidiasis).
• Reduce levels of TNF-alpha (an inflammatory marker), NF-kB, and F-2 isoprostanes (oxidative stress markers).

There is growing evidence that intracellular glutathione levels in antigen-presenting cells (macrophages, for example) may influence Th1/Th2 cytokine response and promote a balanced immune reaction.

In addition, due to its selective effect on cancer cells, SAG is emerging as a promising new substance for lymphoma patients since it increases cell apoptosis.

Why opt for a S-acetyl Glutathione Supplement?

Various studies confirm that this form is better absorbed through the intestinal wall because its acetyl bond prevents oxidation and facilitates the molecule's diffusion into cells after intestinal absorption. It is this acetylation that prevents the breakdown of glutathione. Thus, SAG directly enters cells and, once inside, cytoplasmic thioesterases (sulfur atoms) convert it into reduced glutathione by removing the acetyl group. This increases total glutathione and the percentage of reduced glutathione, positively impacting oxidative stress biomarkers. In fact, SAG is an active antioxidant in all tissues and supports immune function.

To boost the effect of SAG and restore glutathione levels, a precursor of this antioxidant is also available to buy from the Supersmart catalog: N-Acetyl Cysteine (NAC), a particular form of L-cysteine. Similar to methionine, this amino acid contains a sulfur atom and contributes to glutathione production. Other amino acids, such as Lysine and Branched-Chain Amino Acids (BCAA’s) with leucine, isoleucine, and valine, may also be of interest for the synthesis of active molecules. SAG also complements our other two forms of glutathione, Perlingual Glutathione and Reduced Glutathione. It is now the most advanced and effective way of increasing essential endogenous antioxidant levels.

Does This Supplement Have Side Effects?

S-acetyl glutathione is a supplement with no documented severe side effects. Before adding any supplement to your diet, it is strongly recommended to do your research.

You will find plenty of scientific studies into the ingredients of this antioxidant supplement, alongside anecdotal evidence. Connecting with others who have already added an s-acetyl glutathione supplement to their diets will help you understand what you can expect.

No serious side effects have been noted from s-acetyl glutathione capsules, but mild side effects are possible when misused. Always ensure you follow the recommended daily dosage on the package. Attempting to consume more to acquire additional s-acetyl glutathione benefits will increase the risk of side effects.

Finally, speak to your doctor if you are already taking prescription medications. Your doctor will assess the supplement and your medical history to determine if you are at risk for s-acetyl glutathione side effects due to negative drug interactions.

Overall, this supplement is deemed safe for human consumption as part of a healthy lifestyle.

Buy S-acetyl Glutathione capsules to benefit from their anti-aging properties.

How Many S-Acetyl Glutathione Capsules Should I Take Daily?

Learning how to take s-acetyl glutathione will allow you to maximize the benefits of these supplements while avoiding unpleasant side effects.

We recommend you to take three capsules per day, preferably 30 minutes before each meal, with a glass of water. These supplements are best consumed on an empty stomach to aid absorption into the bloodstream.

If you have an acidic stomach, it is recommended to take s-acetyl glutathione supplements 30 minutes after eating to avoid an upset stomach.

Note that if you experience uncomfortable sensations when trying s-acetyl glutathione, stop taking these supplements and consult a healthcare professional. Your doctor can examine your medical history and determine why you may be experiencing side effects.

However, as long as you follow the recommended daily dosage, there is a low chance of experiencing side effects.

1. Grune, T., T. Reinheckel, M. Joshi and K. J. Davies (1995). "Proteolysis in cultured liver epithelial cells during oxidative stress. Role of the multicatalytic proteinase complex, proteasome." J Biol Chem 270(5): 2344-51
2. Hensley, K., N. Hall, R. Subramaniam, P. Cole, M. Harris, M. Aksenov, M. Aksenova, S. P. Gabbita, J. F. Wu, J. M. Carney and et al. (1995). "Brain regional correspondence between Alzheimer's disease histopathology and biomarkers of protein oxidation." J Neurochem 65(5): 2146-56.
3. Schulz et al, Glutathione, oxidative stress and neurodegeneration, Eur J Biochem 267 (16):4904-11, 2000