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Niacinamide Supplement
Niacinamide Supplement
0438Niacinamide SupplementSize
Sans nano-particulesSans glutenVegan
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Best if used before 08/30/2025

Niacinamide is a powerful form of vitamin B3.

  • Improves joint mobility.
  • Prevents cell damage and improves cell regeneration.
  • Reduces the psychological effects of stress and anxiety.
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Niacinamide 500 mg Supplement with Anti-Aging Properties

Niacinamide, or nicotinamide, is one of two vitamin B3 (niacin) forms, now available in vegetarian capsules in SuperSmart's online catalog. Niacinamide is essential for hundreds of enzymatic reactions; research has shown its benefits in arthritis, asthma, diabetes, cardiovascular disease, stress, and stroke.

What are the benefits associated with Niacinamide?

Niacinamide has been recognized for over 50 years for its benefits in treating arthritis. It improves joint mobility and the severity of arthritis in general, allowing doses of anti-inflammatory drugs to be lowered.

Niacinamide presents the following benefits:

  • In diabetics, it prevents cell damage, improves regeneration, reduces glycated hemoglobin levels, and improves glycemia parameters.
  • It improves the condition of alcoholics suffering from chronic pancreatitis.
  • Together with niacin, it has been used since 1940 to treat several psychiatric diseases, particularly schizophrenia.
  • It is used to treat various inflammatory skin conditions and pigmentation disorders.
  • It reduces the psychological effects of stress and anxiety.
  • It represents a potentially effective treatment for adolescent behavioral problems.
  • It helps stabilize the ATP/ADP ratio in the brain and, as a result, energy levels.

Gene therapy research has also increased interest in niacinamide; a gene promoting longevity called Sir2 (silent information regulator 2) produces the protein Sir2p, which extends the lifespan of cells. It controls the rate of cell aging by regulating the production of genetic 'waste products', the accumulation of which can destroy the cell.

This protein depends on its activity in the presence of nicotinamide-adenine-dinucleotide (NAD) within the cell. Niacinamide supplementation with vegetarian capsules helps increase intracellular NAD levels directly and thus the activity of the anti-aging protein Sir2p. Niacinamide is thus emerging as a first-generation tool in anti-aging gene therapy. This safe, effective, inexpensive nutrient is essential to your anti-aging program.


Living with osteoarthritis can prevent you from doing the things you love. And most people will experience worsening symptoms over time, especially as they enter their golden years.

However, according to the Arthritis Foundation, preliminary studies have uncovered the potential benefits of niacinamide capsules for reducing the intensity of symptoms.

By taking a niacinamide 500 mg supplement, you can experience a reduction in your symptoms and less reliance on nonsteroidal anti-inflammatory drugs because of vitamin B3's anti-inflammatory effects.


Additionally, the anti-inflammatory effects of a nicotinamide supplement can also benefit those with asthma. According to the Cleveland Clinic, inflammation swells the lining of your airways and produces mucus, increasing the chances of experiencing an asthma attack.

For this reason, the best vitamin B3 supplement could also benefit people living with asthma by attacking the inflammation in the airways and lungs.


Treating diabetes symptoms is complex because some otherwise beneficial compounds could have the side effect of increasing your blood glucose levels. So over the years, scientists have worked to uncover new treatments to benefit both type 1 and type 2 diabetes patients.

In the past, large quantities of niacin have been associated with elevated glucose levels, making it inappropriate for treating diabetes.

However, new evidence has come to light and illustrates that dietary niacin supplementation in small quantities could reduce diabetes-related problems.

Cardiovascular Disease

Heart disease is one of the biggest killers in America and is responsible for the deaths of hundreds of thousands of people every year. While proper diet and regular exercise are the cornerstones of reducing the risk, supplements like niacin can also help.

Niacin has been used to treat people with heart disease or high-risk patients for over 40 years. Studies have frequently shown that vitamin B3 is a promising candidate for preventing cardiovascular disease. It lowers blood cholesterol, a primary risk factor for that particular health issue.


Severe stress contributes to various physical and mental health conditions. While this is well-known, many people find it challenging to achieve ordinary stress reduction due to their lifestyles. However, this supplement could aid you in reducing stress.

Severe niacin deficiencies have been associated with cognitive decline, including dementia and memory loss. However, according to Harvard University, studies have shown that niacin protects brain cells from stress.

While vitamin B3 capsules cannot cure all forms of stress, they can support a low-stress lifestyle when combined with other supplements and a balanced diet.


As outlined above, one of niacinamide's 500 mg benefits is to protect people against cardiovascular disease.

Since niacinamide 500 mg reduces cholesterol levels, it is easy to denote that it can reduce your risk of stroke. Since high cholesterol is one of the main contributory factors of stroke at any stage of life, taking a niacinamide supplement could be beneficial for lowering your stroke risk.

Importance of B3

Vitamin B3 is an essential B vitamin for the body. As one of the eight B vitamins the body relies on to function, B3 helps convert the food you eat into energy.

It also helps the human body use the proteins and fats acquired from food. Moreover, the Mayo Clinic outlines that this B vitamin helps keep your digestive and nervous systems, as well as your skin healthy.

In short, B3 is a vitamin your body cannot do without.

What Do Studies Say About Niacinamide for Skin?

One of the most exciting revelations of niacinamide 500 mg supplements is how they benefit the skin.

These supplements have been shown to potentially prevent new skin cancer or precancerous skin spots from emerging. This is all down to niacinamide's close cousin, nicotinamide.

This benefit has led to some manufacturers incorporating niacinamide into their sunscreens.

Besides cancer, niacinamide 500 mg capsules have also been proven to benefit skin appearance. According to one small study, combining niacinamide with other skin brighteners, such as retinol, reduced dark spots and fine lines to enhance radiance and texture.

Finally, research has also shown that niacinamide in topical form can improve the appearance of fine lines, wrinkles, and sallowness.

What are the Side Effects Associated with Niacinamide Capsules?

Niacinamide capsules are generally well-tolerated by most people. While some side effects have been noted, these have been attributed to adverse drug interactions and taking these supplements in large amounts.

Even so, most side effects are viewed as exceptionally mild and non-health-threatening. However, we always recommend doing your research to ensure that this is the right supplement for you.

You should also contact your doctor and talk to them about the side effects of niacinamide 500 mg, especially if you are already taking prescription medications.

What is Unique About this Supplement?

Niacinamide has been established as possessing a range of health benefits for people of all ages. In response, SuperSmart has worked to craft this supplement from vegetarian-friendly ingredients without diminishing the benefits of niacinamide.

The most significant benefit of niacinamide 500 mg is that it does not come with the side effects of taking ordinary pure niacin, such as flushing.

This supplement uses the finest ingredients and no unwanted add-ons. This rigorous approach to supplement creation makes our niacinamide supplement safe for most people concerned about their health.

Buy your Niacinamide supplement today!

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Daily serving: 4 capsules
Number of servings per bottle: 45
Quantity per serving
Niacinamide 2,000 mg
Other ingredient: acacia gum.

Each vegetarian capsule contains 500 mg of niacinamide.
Directions for use

What is the Best Way to Take Niacinamide Capsules?

Ordinarily, niacin is water-soluble, making it suitable to take as a supplement before meals. However, due to the ingredients in SuperSmart’s capsules, this is a fat-soluble supplement, meaning you should take it with your meals.

Taking it with your meals aids the body’s absorption of this supplement, enabling you to reap its benefits.

We recommend you to take three to four capsules daily. Exceeding the recommended daily dosage will not provide additional benefits and may increase the risk of side effects.

We strongly recommend contacting your doctor if you experience unpleasant or uncomfortable sensations.

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  1. Jongkind, J.F., Verkerk, A., and Poot, M., Glucose flux through the hexose monophosphate shunt and NADP(H) levels during in vitro ageing of human skin fibroblasts, Gerontology 33 (5) (1987) 281- 286.
  2. Gilchrest, B.A., and Yaar, M., Ageing and photoageing of the skin: Observations at the cellular and molecular level, Br. J. Dermatol., 127 Suppl 41 (1992) 25-30.
  3. Seitz, H.K., Xu, Y., Simanowski, U.A., and Osswald, B., Effect of age and gender on in vivo elimination, hepatic dehydrogenase activity and NAD+ availability in F344 rats, Res. Exp. Med., 192 (3) (1992) 205-212.
  4. Oblong, J.E., Bissett, D.L., Ritter, J.L., Kurtz, K.K., and Schnicker, M.S., »Niacinamide stimulates collagen synthesis from human dermal fibroblasts and differentiation marker in normal human epidermal keratinocytes: Potential of niacinamide to normalize aged skin cells to correct homeostatic balance, 59th Annual Meeting American Academy of Dermatology, Washington, 2001.
  5. Paul Matts et al. A Review of the range of effects of niacinamide in human skin, IFSCC Magazine – vol. 5, no 4 / 2002
  6. Maiese K, Chong ZZ, Hou J, Shang YC: The vitamin nicotinamide: translating nutrition into clinical care. Molecules 2009;14:3446– 3485.
  7. Hoffer A: Biochemistry of nicotinic acid and nicotinamide. Psychosomatics 1967; 8: 95– 100
  8. E. Jeffrey Metter. Comparison of Exercise Response to Resistive Strength Training in Young and Old Subjects, National Institute on Aging, National Institutes of Health. www.grc.nia.nih.gov

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