Bioperine – Black Pepper Supplement for Digestion and Nutrient Absorption *

Bioperine® is a highly concentrated black pepper extract (Piper nigrum), standardized to 95% piperine, designed to help support digestive health and nutrient bioavailability.*

What is Piperine?

Naturally found in black pepper, piperine is responsible for its spicy flavor.* For more than two decades, it seems to have been studied for its ability to potentially help enhance nutrient absorption.*

Piperine may be viewed as a key component in traditional Ayurvedic practices and be known for its synergistic use in formulations aimed at improving digestion and metabolic function.*

Modern studies seem to suggest that it may help enhance the bioavailability of certain nutrients, including selenium and vitamin C, by possibly notable margins.* Here are a few examples of micronutrients that may show improved absorption when combined with piperine:*

• Curcumin;*
• Iron;*
• Resveratrol;*
• Selenium;*
• Vitamin B6;*
• Beta-Carotene;*
• Extracts of Boswellia serrata;*
• Extracts of Ginkgo biloba;*
• Proteins from dietary sources.*

Potential Mechanisms of Action of Bioperine®*

Bioperine® may help support absorption through three mechanisms of action:*

• It may help increase intestinal activity of glycoprotein-P, which might be involved in the transport of nutrients.*
• It might influence the process of glucuronidation by potentially modulating glucuronic acid levels and certain transferase enzymes, which could support the natural removal of compounds through urine.*
• It could help boost thermogenesis, a process that may support nutrient uptake by stimulating the release of thermogenic messengers such as catecholamines.*

Potential Benefits Associated with Bioperine®*

In addition to potentially optimizing bioavailability, piperine may offer digestive benefits.* In fact, it might:*

• Help support absorption of nutrients such as curcumin, selenium, resveratrol, vitamin B6, and iron.*
• Contribute to digestive enzyme activity such as salivary amylase and trypsin (an enzyme present in pancreatic juice, that may help break proteins).*
• Play a role in supporting digestive comfort and efficiency.*

Note: because piperine may influence the absorption of certain compounds, including some medications, it is recommended to consult a healthcare professional before combining this supplement with any prescription treatments.*

How is Bioperine® Produced?*

Black pepper (Piper nigrum) is a tropical climbing vine that seems to thrive in forested, equatorial regions between 15 degrees north and 15 degrees south latitude.* It may be widely cultivated for its pungent berries, also known as drupes.*

The berries are harvested when they begin to turn red – a potential indicator that their essential oil content is at its peak.* After harvesting, they are deseeded, sun-dried until they darken, and briefly heated in boiling water to help release heat-stable enzymes.* The final step involves open-air drying and the removal of the outer layer to prepare them for extraction.*

In the case of Bioperine®, the black pepper extract is carefully standardized to deliver a concentrated 95% piperine content.*

While piperine can be produced synthetically in laboratory settings using specific enzymes like piperotransferase, Bioperine® delivers piperine in its natural form – extracted directly from black pepper drupes.*