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Artemisinin is the best immunostimulant for fighting infections and corrupted cells.
  • Extracted from artemisinin, the active principle of the plant Artemisia annua.
  • Standardized to 98% artemisinin.
  • Helps cleanse and protect the body by supporting it in fighting exogenous agents.
  • Active substance used for thousands of years for its anti-parasitic, anti-bacterial and anti-viral properties.
  • Helps eliminate damaged cells from the body.
  • Helps relieve inflammation and regulate immune system reactions.
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Flowers of the plant Artemisia annua

Artemisinin

Artemisinin is a highly effective dietary supplement that helps cleanse the body, boost the immune system, fight infection and contain the proliferation of harmful cells, now available to buy at Supersmart. This carefully developed and 100% natural immunostimulant is essentially composed of the active substance artemisinin, the discovery of which earned the scientist responsible the Nobel prize in medicine.

Artemisinin is obtained from the plant Artemisia annua, or sweet wormwood, a herbaceous plant used in Chinese medicine for millennia for its ability to eliminate parasites, viruses and bacteria. Its active principle, artemisinin, was identified at the beginning of the 1970s and quickly became the key compound in medicines currently used to treat malaria. Highlighted more recently, artemisinin’s anti-cancer, anti-inflammatory and immunomodulatory benefits are attracting keen interest among the scientific community.

What exactly is sweet wormwood and its active principle artemisinin?

A crucial plant in Far Eastern pharmacopoeia

Sweet wormwood, or to give it its Latin and Chinese names, Artemisia annua and qing hao, is a glabrous and highly aromatic plant belonging to the large Asteraceae family. Originating from Asia (before spreading to Europe and Africa), it has been an important component of Chinese herbalism for more than 2000 years.

It was traditionally consumed in the form of a decoction, to treat fevers and parasitic infections, and in particular, to overcome malaria.

The rediscovery of sweet wormwood has had a significant impact in containing the spread of this highly dangerous tropical disease, which is caused by a parasite entering the bloodstream from a mosquito bite. It’s interesting to note that this identification of artemisinin actually came about … at the height of the Vietnam war (1).

Nobel prize awarded for the discovery of artemisinin

The ranks of the North Vietnamese army were being ravaged by malaria and they asked Mao Zedong’s China for help. In March 1972, inspired by Chinese traditional medicine, the Chinese professor Tu Youyou, put the virtues of Artemisia annua back in the spotlight when she succeeded in isolating its active principle: artemisinin. (2) (3)

Out of this came an effective remedy for malaria. Nowadays, the most widely used treatment for this disease is still produced using this substance or its derivatives. Its discovery went on to earn Professor Tu Youyou the Nobel prize for medicine in 2015.

How does this sesquiterpene lactone work in the body?

Let’s turn now to the nature and action of artemisinin. This molecule is actually a sesquiterpene lactone which has a functional group with two atoms of oxygen. They are linked by a peroxide bridge, to which its anti-malarial properties appear to be attributed. It’s thought this bridge acts by blocking the enzyme that ensures the parasite is provided with calcium thus impeding its growth in the body.

Another mechanism of action may lie in its ability to generate free radicals in the presence of iron, a trace-element abundant in both parasites and cancer cells. Once disseminated, it seems the free radicals eliminate the parasites by making their cell membranes explode. (4)

What are the benefits offered by the supplement Artemisinin?

Erecting a barrier against parasitic infections

Day after day, your body faces waves of infectious agents (bacteria, viruses, parasites...) all of which try to enter your system and take up residence, causing all sorts of illnesses. Artemisinin acts to optimise your immune system function and boost your resistance to these multiple external attacks.

In fact, artemisinin does more than just stop Plasmodium, the parasite responsible for malaria: it combats many other potential infections. In particular, it is recognized for treating schistosomiasis, also known as bilharzia, an endemic disease caused by hematophagous parasite worms called schistosomes. One study showed that taking artemisinin-based drugs reduced the number of these worms, the presence of their eggs and the parasite’s fertility in the body. (5)

Artemisinin also has a significant effect against helminths, the term for worm-like parasites, the best-known of which is tapeworm. Did you know that 1.5 billion people are infected with soil-transmitted helminths globally? A study from 2018 confirmed that “artemisinin (ART) and its derivatives are potentially effective medicines for treating various helminthic diseases important for public health”. The study was conducted on a wide range of helminths:

  • Nematodes (Toxocara canis, Trichinella spiralis, Haemonchus contortus, Meloidogyne spp., Globodera rostochiensis and Xiphinema index).
  • Cestodes (Echinococcus spp. and Taenia crassiceps).
  • Trematodes (Echinostoma spp., Fasciola Clonorchis sinensis, Opisthorchis viverrini, Paragonimus westermani, Heterophyes heterophyes and Paramphistomum microbothrium).
  • And parasites monogenea (Dactylogyrus and Gyrodactylus).(6)

Another study from 2017 found that “artemisinin and its derivatives may constitute good alternatives for the treatment of protozoal infections”. (7)

Boosting the body’s ability to resist bacteria

As well as constituting a barrier against a large number of parasites, artemisinin has also shown an impressive ability to fight bacterial infections.

Let’s take the example of a well-known bacterial disease: Lyme disease, also known as Lyme borreliosis. Transmitted by a bite from a contaminated tick, usually during a walk in a forest, Lyme disease can cause pain and fever as well as neurological, respiratory and eye problems. A 2016 study showed that taking anti-malarials such as artemisinin produced better results than the antibiotics currently used to treat Lyme disease. (8) (9)

A study by Professor Yesha Patel and his team highlighted the fact that this active substance was also able to combat another well-known bacterial disease, tuberculosis. Tested in in vitro culture, artemisinin was shown to act synergistically with rifampicin, isoniazid and ethambutol against the bacilli Mycobacterium bovis and Mycobacterium tuberculosis H37Ra. By increasing peroxide levels in treated cells, artemisinin caused the membranes of attacking bacteria to disintegrate significantly reducing their numbers. (10)

Stimulating the immune system against viruses

It’s also significant that this active principle has been shown to be effective at fighting viruses. In a study from November 2018, the German researcher Thomas Effert observed there was good in vitro and in vivo evidence of the positive effects of artemisinin and its derivatives against certain DNA viruses, namely:

  • Cytomegalovirus (CMV).
  • Human herpes virus type 6 (HHV-6) and herpes simplex virus (HSV-1 et HSV2).
  • Epstein-Barr virus (EBV).
  • Hepatitis B virus (HBV).
  • And to a lesser extent, polyomaviruses and papillomavirus. (11)

Artemisinin supports the body’s fight against its own corrupt cells

In terms of cleansing the body, Artemisinin not only protects you from external agents: this high-quality nutritional supplement also helps to get rid of your own corrupted cells .

What’s the mechanism involved here? As previously mentioned, it seems artemisinin naturally generates free radicals which destroy diseased cells and prevent them from multiplying. This has the advantage of being a specifically targeted action which does not affect healthy cells. (12) (13)

A number of scientific studies have confirmed artemisinin’s effects on cancer cells and tumors:

  • A study from 2017 demonstrated that artemisinin offers powerful anti-cancer properties.(14)
  • A study from the same year confirmed that this substance inhibited the proliferation of cancer cells in the gall bladder.(15)
  • Another study found that artemisinin and its derivatives were able to suppress TGF-β signaling in vivo, which neutralizes fibroblasts associated with cancer and triggers inhibition of metastasis in breast cancer (16)
  • With regard to lung cancer, artemisinin has been shown to suppress the progress of lung tumors by inhibiting the Wnt/β-catenin pathway. (17)
  • Other studies have highlighted cytotoxic effects against a wide range of cancers, in vitro and in vivo.(18) (19)
  • We should also mention additional studies which have identified all the ways in which artemisinin eliminates tumors: breaking down cancer cells’ DNA, inducing apoptosis, autophagy, necroptosis, oncosis, inhibition of the cell cycle in phase G0/G1, inhibition of angiogenesis... (20) (21)

Note: during this temporary phase of elimination of harmful cells, it’s best to avoid taking antioxidant supplements which may hinder the oxidative effect of artemisinin.

Artemisinin’s anti-inflammatory and immunomodulatory action

A study from 2015 reported that artemisinin “has powerful anti-inflammatory and immune-regulatory properties”, which can balance its immune-stimulant character. (22)

These anti-inflammatory effects have been attributed to the inhibition of multiple receptors: Toll-like receptors, Syk tyrosine kinase, phospholipase Cγ, etc (23)

Taking the example of gout, the inflammatory condition caused by excess uric acid in the blood, a study in September 2019 showed that artemisinin was able to inhibit activation of the NLRP3 inflammasome (by suppressing interaction between NLRP3 and the NEK7 protein), and thus ease this painful problem. (24)

Another study revealed that artemisinin exerts a positive effect on neuroinflammation: regulating the inflammatory process within the central nervous system, eliminating systemic inflammation, relieving intestinal inflammation ... (25)

According to researcher Ives Charlie-Silva, artemisinin “is able to modulate the immune response by regulating cell proliferation and the release of cytokines”. The active principle in sweet wormwood thus helps calm excessive auto-immune responses. (26)

What does the supplement Artemisinin contain?

Formulated to act as a biological shield against infection, the nutritional supplement Artemisinin contains only natural ingredients.

Its main ingredient, artemisinin, is obtained from the aerial parts of Artemisia annua. Also known as sweet wormwood, this plant was widely used in traditional Chinese medicine, as well as being very popular in Europe, as far back as Antiquity: it was recognized for its ability to strengthen the body, relieve digestive problems and painful periods, and act as a worming treatment … In this product, the artemisinin extract is standardized to 98% to ensure optimal efficacy.

This immunostimulant is completed and stabilised by acacia gum (a sap exudate from the African tree Acacia senegalensis) and white rice flour.

How should you take Artemisinin capsules?

It couldn’t be simpler: just take two capsules a day. It is distributed throughout the body and brain very rapidly. It is also very well tolerated by the body as long as you stick to the recommended dose.

Remember, though, it is always advisable to consult your doctor before beginning a course of dietary supplements. Also avoid taking artemisinin during pregnancy.

To get the maximum benefits from Artemisinin supplementation, you should also try to:

  • Take regular exercise, as it reduces the risk of infection and facilitates healing (27).
  • Look after your gut microbiota which plays a key role in your defenses by taking probiotics (such as Probio Forte™) (28).
  • Improve the quality of your sleep in order to reduce your susceptibility to infections and lower your inflammation (29).
  • Reduce your stress levels, as excessive and prolonged production of cortisol, the stress hormone, plays a part in weakening your natural defenses (30).
  • And supplement with magnesium (for example, by taking OptiMag) to reduce fatigue and, again, boost your immunity. (31)

Buy Artemisinin to support the immune system.

Composition
Dail dose: 2 capsules
Number of doses per pack: 30

Amount
per dose

Artemisinin (extracted from the aerial parts of Artemisia annua standardized to 98% artemisinin) 300 mg
Other ingredients: acacia gum, white rice flour.

Each vegetarian capsule contains 150 mg of artemisinine.
Directions for use
Adults. Take 2 capsules a day.
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EDLINGER Sandra
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it helps perfectly fight against viruses. infections are gone after 3 capsules twice daily.
References
  1. Zyad A, Tilaoui M, Jaafari A, Oukerrou MA, Mouse HA. More insights into the pharmacological effects of artemisinin. Phytother Res. 2018;32(2):216–229.
  2. Niyi Awofeso, « Project 523: transformation of Artemisinin from traditional Chinese medicine to mainstream anti-malaria chemotherapy », Spatula DD, vol. 1, no 2,‎ 2011, p. 115.
  3. Tu Y. Artemisinin-A Gift from Traditional Chinese Medicine to the World (Nobel Lecture). Angew Chem Int Ed Engl. 2016;55(35):10210–10226.
  4. Lai H, Sasaki T, Singh NP, Messay A. Effects of artemisinin-tagged holotransferrin on cancer cells. Life Sci. 2005;76(11):1267–1279.
  5. Saeed MEM, Krishna S, Greten HJ, Kremsner PG, Efferth T. Antischistosomal activity of artemisinin derivatives in vivo and in patients. Pharmacol Res. 2016;110:216–226.
  6. Lam NS, Long X, Su XZ, Lu F. Artemisinin and its derivatives in treating helminthic infections beyond schistosomiasis. Pharmacol Res. 2018;133:77–100.
  7. Loo CS, Lam NS, Yu D, Su XZ, Lu F. Artemisinin and its derivatives in treating protozoan infections beyond malaria. Pharmacol Res. 2017;117:192–217.
  8. Feng J, Weitner M, Shi W, Zhang S, Sullivan D, Zhang Y. Identification of Additional Anti-Persister Activity against Borrelia burgdorferi from an FDA Drug Library. Antibiotics (Basel). 2015;4(3):397–410. Published 2015 Sep 16.
  9. Feng J, Shi W, Zhang S, Sullivan D, Auwaerter PG, Zhang Y. A Drug Combination Screen Identifies Drugs Active against Amoxicillin-Induced Round Bodies of In Vitro Borrelia burgdorferi Persisters from an FDA Drug Library. Front Microbiol. 2016;7:743. Published 2016 May 23.
  10. Patel YS, Mistry N, Mehra S. Repurposing artemisinin as an anti-mycobacterial agent in synergy with rifampicin. Tuberculosis (Edinb). 2019;115:146–153.
  11. Efferth T. Beyond malaria: The inhibition of viruses by artemisinin-type compounds. Biotechnol Adv. 2018;36(6):1730–1737.
  12. Bhaw-Luximon A, Jhurry D. Artemisinin and its derivatives in cancer therapy: status of progress, mechanism of action, and future perspectives. Cancer Chemother Pharmacol. 2017;79(3):451–466.
  13. Zyad A, Tilaoui M, Jaafari A, Oukerrou MA, Mouse HA. More insights into the pharmacological effects of artemisinin. Phytother Res. 2018;32(2):216–229.
  14. Kumari K, Keshari S, Sengupta D, Sabat SC, Mishra SK. Transcriptome analysis of genes associated with breast cancer cell motility in response to Artemisinin treatment. BMC Cancer. 2017;17(1):858. Published 2017 Dec 15.
  15. Jia J, Qin Y, Zhang L, et al. Artemisinin inhibits gallbladder cancer cell lines through triggering cell cycle arrest and apoptosis. Mol Med Rep. 2016;13(5):4461–4468.
  16. Yao Y, Guo Q, Cao Y, et al. Artemisinin derivatives inactivate cancer-associated fibroblasts through suppressing TGF-β signaling in breast cancer [published correction appears in J Exp Clin Cancer Res. 2019 Nov 5;38(1):451]. J Exp Clin Cancer Res. 2018;37(1):282. Published 2018 Nov 26.
  17. Tong Y, Liu Y, Zheng H, et al. Artemisinin and its derivatives can significantly inhibit lung tumorigenesis and tumor metastasis through Wnt/β-catenin signaling. Oncotarget. 2016;7(21):31413–31428.
  18. Li X, Gu S, Sun D, Dai H, Chen H, Zhang Z. The selectivity of artemisinin-based drugs on human lung normal and cancer cells. Environ Toxicol Pharmacol. 2018;57:86–94.
  19. Wong YK, Xu C, Kalesh KA, et al. Artemisinin as an anticancer drug : Recent advances in target profiling and mechanisms of action. Med Res Rev. 2017;37(6):1492–1517.
  20. Efferth T. From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy. Semin Cancer Biol. 2017;46:65–83.
  21. Slezakova S, Ruda-Kucerova J. Anticancer Activity of Artemisinin and its Derivatives. Anticancer Res. 2017;37(11):5995–6003.
  22. Hou L, Huang H. Immune suppressive properties of artemisinin family drugs. Pharmacol Ther. 2016;166:123–127.
  23. Ho WE, Peh HY, Chan TK, Wong WS. Artemisinins: pharmacological actions beyond anti-malarial. Pharmacol Ther. 2014;142(1):126–139.
  24. Kim SK, Choe JY, Park KY. Anti-inflammatory effect of artemisinin on uric acid-induced NLRP3 inflammasome activation through blocking interaction between NLRP3 and NEK7. Biochem Biophys Res Commun. 2019;517(2):338–345.
  25. Shi Z, Chen Y, Lu C, et al. Resolving neuroinflammation, the therapeutic potential of the anti-malaria drug family of artemisinin. Pharmacol Res. 2018;136:172–180.
  26. Charlie-Silva I, Fraceto LF, de Melo NFS. Progress in nano-drug delivery of artemisinin and its derivatives: towards to use in immunomodulatory approaches. Artif Cells Nanomed Biotechnol. 2018;46(sup3):S611–S620.
  27. Booth FW, Roberts CK, Thyfault JP, Ruegsegger GN, Toedebusch RG. Role of Inactivity in Chronic Diseases: Evolutionary Insight and Pathophysiological Mechanisms. Physiol Rev. 2017;97(4):1351–1402.
  28. Perez Martinez G., Bauerl C., Collado M.C. Understanding gut microbiota in elderly’s health will enable intervention through probiotics. Benef. Microbes. 2014;5:235–246.
  29. Doherty R, Madigan S, Warrington G, Ellis J. Sleep and Nutrition Interactions: Implications for Athletes. Nutrients. 2019;11(4):822. Published 2019 Apr 11.
  30. Cohen S, Janicki-Deverts D, Doyle WJ, et al. Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk. Proc Natl Acad Sci U S A. 2012;109(16):5995–5999.
  31. Tam M, Gómez S, González-Gross M, Marcos A. Possible roles of magnesium on the immune system. Eur J Clin Nutr. 2003;57(10):1193–1197.

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