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BPC-157
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BPC-157
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$48.00
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Description
A regenerating substance which accelerates healing and recovery
  • Intended for research purposes only (not approved for human consumption).
  • Peptide with powerful reparative and cytoprotective properties. Its benefits are known colloquially as the ‘Wolverine effect’.
  • Highly-concentrated synthetic product that replicates a substance naturally present in small amounts in human gastric juice.
  • Promotes wound-healing and angiogenesis (the formation and repair of blood vessels).
  • Supports rapid recovery of muscles, tendons, ligaments and bones.
  • Helps improve the health of several organs: heart, liver, intestines...
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BPC-157

The peptide BPC-157 is recognized for its powerful regenerative and cytoprotective capacities. This active substance is naturally present in small amounts in the human stomach. (1)

In particular, it has the ability to significantly accelerate wound-healing, facilitate the recovery of muscles and tendons, and combat heart arrhythmia and intestinal inflammation. (2-4)

Its extraordinary effects on repairing the body are generating considerable optimism among scientists and health specialists.

What exactly is BPC-157?

Firstly, BPC-157 is a peptide – a chain of amino acids. More specifically, it is a pentadecapeptide which means it’s composed of precisely 15 amino acids.

The term BPC stands for Body Protective Compound. Why so? Well a small amount of BPC-157 is actually secreted in the body’s gastric juices in order to protect and repair the stomach and gut. But as several recent scientific studies have demonstrated, this multi-functional substance confers many other health benefits.

Hence the desire to create a synthetic product highly-concentrated in BPC-157 that can simultaneouslypromotewound-healing and remedy many dysfunctions in the body.

What are the effects of BPC-157?

Current studies show that BPC-157:

  • significantly speeds up wound-healing; (5)
  • facilitates the repair of numerous injuries: muscle tears, joint pain, sprains, strains, fractures … making it an excellent substance for reducing post-trauma recovery time and ensuring optimal rebuilding of the injured area (6-7);
  • is able to combat various diseases of the heart, liver, stomach and intestines, by countering heart arrhythmia, hepatic fibrosis, gastric ulcers, Crohn’s disease, ulcerative colitis, etc. (8-12)

How does BPC-157 accelerate healing and recovery?

It promotes the growth of cells that make up the body’s tissues

An August 2019 study from England examined all the experiments conducted on this subject on small rodents. It found that BPC-157 consistently showed positive and fast-acting healing effects for many types of injury and for various soft tissues: tendons, ligaments, muscles... (13) That’s why its action is often referred to the ‘Wolverine effect’ – from the American super-hero character with ultrafast regenerating powers.

One research team tested the regenerative potential of this pentadecapeptide on damaged Achilles tendons in rats. BPC-157 was found to « promote the growth ex vivo of tendon fibroblasts as well as cell survival ». (14) In other words, BPC-157 is able to accelerate the growth of tissue-constituting cells. It can also optimise growth hormone receptor function in fibroblasts. (15)

Another study on rats which had suffered crushed muscles and had been given BPC-157 (administered intraperitoneally or topically) showed that this peptide improved muscle recovery(16). An acceleration in healing of acute ligament damage was also observed. (17)

Research suggests that

pentadecapeptide may also neutralize neuronal necrosis, the loss of myelin around nerve fibres and the formation of cysts in rats with spinal cord injury. (18) More generally, one study found that injured rats given BPC-157 exhibited “functional, biomechanical, macroscopic and histological healing improvements. (19)

BPC-157 stimulates formation of blood vessels

BPC-157 also seems to act by facilitating angiogenesis, the formation and repair of blood vessels (20). The greater the number of blood vessels, the more nutrients are able to reach the injured tissue and help repair it.

A study noted that BPC-157 may also be a powerful angio-modulator”, able to optimise vascular response and stimulate the healing process. (21)

This substance also helps protect the endothelium (the inner layer of blood vessels). In addition, it maintains the function of thrombocytes, a type of blood cell responsible for stopping bleeding quickly. (22-23)

It supports formation of transitional tissue and collagen deposition

The action of BPC-157 on blood vessels means it is able to stimulate the formation of ‘granulation tissue’ ». (24) This transitional tissue appears after a wound has formed and is responsible for temporarily closing it. It needs a good blood supply from a large number of capillaries. BPC-157 will then support reepithelialisation - the reconstruction of the epithelium (namely the epidermis in the case of a skin wound). (25)

BPC-157 also facilitates the deposition of collagen, a protein which ensures the body’s strength and elasticity. As one study suggested, “the therapeutic mechanism of BPC-157 may be related to the accelerated formation of granulation tissue, reepithelialisation, skin remodelling and the deposition of collagen via the ERK1/2 signaling pathway.” (26)

Studies conducted on rabbits have also demonstrated the osteogenic properties of BPC-157: it has been found to improve healing of bone defects. (27)

Regulation of heart rate, protection of the stomach and intestines ...

The pentadecapeptide BPC-157 has also demonstrated cytoprotective activity, which may benefit many organs. It may also have anticonvulsant properties, capable of improving heart health. One study showed that digitalis-induced cardiac arrhythmia in rats could be prevented and neutralized by BPC-157. (28)

In relation to the liver, BPC-157 is able to combat fragmentary necrosis, focal lytic necrosis and hepatic fibrosis. (29) And this substance is obviously very effective in its original environment, the stomach, against ulcers.

Researchers instilled pure alcohol into a distended rat stomach to induce damage and loss of blood vessels in the gastric artery. They found that administering pentadecapeptide BPC-157 in the stomach triggered blood vessel persistence, associated with inhibition of damage to the stomach, esophagus and duodenum. (30)

And finally, another study described this substance as an “effective anti-ulcer peptide for treating inflammatory bowel disease (PL 14736)”. (31)

Who is likely to find this pentadecapeptide of interest?

Numerous scientists are currently focusing on the remarkable and promising properties of BPC-157. Despite the significant benefits observed to date, it has not yet been officially approved for human consumption. Its specific properties may, however, inspire particular categories of people to follow the research being conducted on it, including:

  • injury victims or those at risk of regular injury;
  • athletes keen to recover quickly from pulled muscles, fractures, sprains ... ;
  • weakened individuals who take longer to heal;
  • those suffering from joint pain;
  • those with stomach ulcers;
  • les those with chronic gastric problems etc.

BPC-157: a few reminders

This product is intended for research purposes only. It is not approved for human consumption. Keep out of reach of young children. Store away from light, heat and humidity.


References

  1. Chang CH, Tsai WC, Lin MS, Hsu YH, Pang JH. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J Appl Physiol (1985). 2011;110(3):774–780.
  2. Gwyer D, Wragg NM, Wilson SL. Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing. Cell Tissue Res. 2019;377(2):153–159/s.
  3. Balenovic D, Bencic ML, Udovicic M, et al. Inhibition of methyldigoxin-induced arrhythmias by pentadecapeptide BPC 157: a relation with NO-system. Regul Pept. 2009;156(1-3):83–89.
  4. Cerovecki T, Bojanic I, Brcic L, et al. Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat. J Orthop Res. 2010;28(9):1155–1161.
  5. Chang CH, Tsai WC, Hsu YH, Pang JH. Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts. Molecules. 2014;19(11):19066–19077. Published 2014 Nov 19.
  6. Gwyer D, Wragg NM, Wilson SL. Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing. Cell Tissue Res. 2019;377(2):153–159/s.
  7. Pevec D, Novinscak T, Brcic L, et al. Impact of pentadecapeptide BPC 157 on muscle healing impaired by systemic corticosteroid application. Med Sci Monit. 2010;16(3):BR81–BR88.
  8. Balenovic D, Bencic ML, Udovicic M, et al. Inhibition of methyldigoxin-induced arrhythmias by pentadecapeptide BPC 157: a relation with NO-system. Regul Pept. 2009;156(1-3):83–89.
  9. Sever AZ, Sever M, Vidovic T, et al. Stable gastric pentadecapeptide BPC 157 in the therapy of the rats with bile duct ligation. Eur J Pharmacol. 2019;847:130–142.
  10. Xue XC, Wu YJ, Gao MT, et al. Protective effects of pentadecapeptide BPC 157 on gastric ulcer in rats. World J Gastroenterol. 2004;10(7):1032–1036.
  11. Sikiric P, Seiwerth S, Brcic L, et al. Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease (PL-10, PLD-116, PL 14736, Pliva, Croatia). Full and distended stomach, and vascular response. Inflammopharmacology. 2006;14(5-6):214–221.
  12. Sikiric P, Hahm KB, Blagaic AB, et al. Stable Gastric Pentadecapeptide BPC 157, Robert’s Stomach Cytoprotection/Adaptive Cytoprotection/Organoprotection, and Selye’s Stress Coping Response: Progress, Achievements, and the Future [published online ahead of print, 2019 Jun 4]. Gut Liver. 2019;10.5009/gnl18490.
  13. Gwyer D, Wragg NM, Wilson SL. Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing. Cell Tissue Res. 2019;377(2):153–159/s.
  14. Chang CH, Tsai WC, Lin MS, Hsu YH, Pang JH. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J Appl Physiol (1985). 2011;110(3):774–780.
  15. Chang CH, Tsai WC, Hsu YH, Pang JH. Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts. Molecules. 2014;19(11):19066–19077. Published 2014 Nov 19.
  16. Novinscak T, Brcic L, Staresinic M, et al. Gastric pentadecapeptide BPC 157 as an effective therapy for muscle crush injury in the rat. Surg Today. 2008;38(8):716–725.
  17. Cerovecki T, Bojanic I, Brcic L, et al. Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat. J Orthop Res. 2010;28(9):1155–1161.
  18. Sikiric P, Seiwerth S, Rucman R, et al. Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications. Curr Neuropharmacol. 2016;14(8):857–865.
  19. Cerovecki T, Bojanic I, Brcic L, et al. Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat. J Orthop Res. 2010;28(9):1155–1161.
  20. Hsieh MJ, Liu HT, Wang CN, et al. Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation. J Mol Med (Berl). 2017;95(3):323–333.
  21. Seiwerth S, Brcic L, Vuletic LB, et al. BPC 157 and blood vessels. Curr Pharm Des. 2014;20(7):1121–1125.
  22. Sikiric P, Seiwerth S, Brcic L, et al. Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease (PL-10, PLD-116, PL 14736, Pliva, Croatia). Full and distended stomach, and vascular response. Inflammopharmacology. 2006;14(5-6):214–221.
  23. Konosic S, Petricevic M, Ivancan V, et al. Intragastric Application of Aspirin, Clopidogrel, Cilostazol, and BPC 157 in Rats: Platelet Aggregation and Blood Clot. Oxid Med Cell Longev. 2019;2019:9084643. Published 2019 Dec 30.
  24. Seiwerth S, Sikiric P, Grabarevic Z, et al. BPC 157’s effect on healing. J Physiol Paris. 1997;91(3-5):173–178.
  25. Huang T, Zhang K, Sun L, et al. Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro. Drug Des Devel Ther. 2015;9:2485–2499. Published 2015 Apr 30.
  26. Huang T, Zhang K, Sun L, et al. Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro. Drug Des Devel Ther. 2015;9:2485–2499. Published 2015 Apr 30.
  27. Sebecić B, Nikolić V, Sikirić P, et al. Osteogenic effect of a gastric pentadecapeptide, BPC-157, on the healing of segmental bone defect in rabbits: a comparison with bone marrow and autologous cortical bone implantation. Bone. 1999;24(3):195–202.
  28. Balenovic D, Bencic ML, Udovicic M, et al. Inhibition of methyldigoxin-induced arrhythmias by pentadecapeptide BPC 157: a relation with NO-system. Regul Pept. 2009;156(1-3):83–89.
  29. Sever AZ, Sever M, Vidovic T, et al. Stable gastric pentadecapeptide BPC 157 in the therapy of the rats with bile duct ligation. Eur J Pharmacol. 2019;847:130–142.
  30. Sikiric P, Seiwerth S, Brcic L, et al. Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease (PL-10, PLD-116, PL 14736, Pliva, Croatia). Full and distended stomach, and vascular response. Inflammopharmacology. 2006;14(5-6):214–221.
  31. Cerovecki T, Bojanic I, Brcic L, et al. Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat. J Orthop Res. 2010;28(9):1155–1161.
Directions for use
For research purposes only. Not approved for human consumption.
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