Nerve Comfort for Supporting Nerve Health and Relieving Nerve-Related Discomfort

Our supplement Nerve Comfort brings together the most beneficial compounds for neuroprotection (protection of nerve cells). Its various ingredients have been selected to help maintain healthy nerve function and reduce nerve-related discomfort.

This innovative formulation is therefore of particular interest in cases of neuropathy. Neuropathy refers to a group of disorders usually caused by damage to peripheral nerves. It can result in pain, numbness, weakness, dysfunction in affected areas, etc. The nerves in question may have been damaged by diabetes, injury, or a deficiency in B vitamins.

Nerve Comfort is part of our brain and nervous system nutrition category.

Nerve Comfort, a Supplement Inspired by Treatments for Neuropathic Pain

Treatments prescribed for neuropathic pain often combine medication with dietary supplements designed to boost intake of certain vitamins and other beneficial nutrients for the nervous system.

Based on the latest scientific advances in neuropathy, Nerve Comfort offers a synergy of 6 carefully selected compounds:

1. N-acetyl cysteine (NAC): this amino acid is the precursor of glutathione, the famous endogenous antioxidant. Glutathione is involved in detoxifying harmful substances and regenerating other antioxidants. It also acts as a guard against various forms of cellular stress and is thus studied for its potential neuroprotective properties (1).
2. Acetyl-L-carnitine: this acetyl ester of L-carnitine is among the most recently researched and promising molecules for relieving neuropathy. Scientific literature suggests it has analgesic (pain relief) properties through the activation of receptors in dorsal root ganglia neurons (modulating the transmission of pain signals). It is also thought to be effective for the loss of sensitivity (2).
3. Benfotiamine: this form of vitamin B1 supports normal nervous system function by improving energy metabolism within nerve cells. Deficiency in vitamin B1 typically manifests as a loss of feeling in extremities and burning pains (3). As well as being a more bioavailable form of vitamin B1 than 'classic' thiamine, benfotiamine appears to offer protection against damage induced by nerve protein glycosylation, a process often accelerated in neuropathy.
4. Alpha-lipoic acid: studies of neuropathy sufferers have shown the potential of alpha-lipoic acid (an endogenous protector naturally present in human cells) for scavenging peripheral nerve lipophilic free radicals and regenerating nerve fibers. This compound appears to be particularly effective in diabetics, in whom uncontrolled hyperglycemia induces oxidative stress which impairs blood flow to neuronal cells and causes neuroprotective antioxidant enzymes to become glycated (hence the frequently observed peripheral nerve damage) (4).
5. Magnesium bisglycinate: magnesium supports normal nervous system and psychological function. Studies suggest this mineral can stabilize calcium channels, exert anti-inflammatory effects, and block NMDA receptors, thus reducing nerve hyperexcitability and pain transmission (5). The selected form, magnesium bis-glycinate, is recognized for having the highest bioavailability and being very well tolerated by the digestive system.
6. Methylcobalamin: this form of vitamin B12 also plays a role in normal nervous system function by supporting repair and regeneration of nerves as well as synthesis of the myelin sheath (which surrounds the nerve). A lack of vitamin B12 is closely associated with the development of peripheral neuropathic disorders (6). The form of vitamin B12 selected, methylcobalamin, has the advantage of being directly usable and easily absorbed by the body.

Neuropathic Pain: What are the Symptoms?

Characteristics of chronic nerve pain

There is no definitive biological marker for neuropathic pain, with diagnosis based primarily on the patient’s description of his or her pain. There are, however, benchmarks summarizing key characteristics that can help doctors arrive at a diagnosis.

Neuropathic pain: typical examples

• Burning-, cold- and/or electric shock-type pain;
• Tingling, prickling, numbness, or itching in the affected area;
• Partial or total loss of sensitivity to touch in the painful area (hypoesthesia or anaesthesia);
• Increased pain perception in response to normally painless stimulus (allodynia) (7).

What Causes Neuropathic Pain?

While there is significant variation in the etiology of neuropathic pain, several common causes have been identified:

• Stroke and brain tumors;
• Diabetic neuropathy in the case of poorly-controlled blood sugar levels, which manifests in peripheral polyneuropathy (8);
• Post-herpetic neuropathy following shingles (9);
• Localized nerve compression: tumors, fractured vertebral discs (neuropathic pain in the legs), impairment of the median nerve in the hand (carpal tunnel syndrome);
• Damage to the spinal cord (accident, multiple sclerosis, etc.);
• Certain surgical procedures (thoracotomy, mastectomy, spinal surgery, etc.);
• Some forms of chemotherapy which exhibit neurotoxicity (10);
• Deficiency in certain B group vitamins (especially B1, B6 and B12) (11).

What is the Difference Between Neurological Pain and Neuropathic Pain?

The terms 'neuropathic pain', 'neurogenic pain', and 'neurological pain' all mean the same thing. Unlike 'nociceptive' pain, they are not triggered by a direct attack on the body (inflammation, trauma, infection, etc.) but by damage to pain detection circuits. Their onset is secondary to damage to or dysfunction of the nervous system (brain, spinal cord, or nerves) (12).

What are the Best Supplements to Take Alongside Nerve Comfort for Neuropathy?

For diabetic neuropathy

For those suffering from diabetic neuropathy, regulating blood glucose levels is critical. Plants such as banaba, in the supplement Glucofit™, which supports glycemic control, or Berberine from barberry, which promotes carbohydrate metabolism, can provide valuable support (with the approval of your diabetes specialist) (20-21).

For curbing nerve inflammation

To slow down nerve inflammation that underlies neuropathic disorders, you could also try turmeric, which through its curcumin content, has antioxidant and anti-inflammatory properties (Curcumin Solution has a form of curcumin 185 times more bioavailable than the standard form) (22). Alternatively, you can find it in synergistic formulations, such as InflaRelief Formula, in which turmeric is combined with 11 other natural substances targeted at inner balance.