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Guduchi – Tinospora cordifolia for Biostimulation of the Defenses

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Guduchi extract, also known as Ayurveda's 'nectar of immortality', excellent for immunity.

  • Supports immune, respiratory, skin, and genitourinary health.
  • Extracted from Tinospora cordifolia, a sacred antioxidant plant in Ayurvedic medicine.
  • Adaptogen plant which also supports mental health.
  • Helps maintain liver health and lipid and glucose metabolism.

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60 Veg. Caps




60 Veg. Caps



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No controversial excipients
No sweeteners

Guduchi is a dietary supplement containing guduchi (Tinospora cordifolia) standardized to 5% bitters and 20% polysaccharides. This climbing plant from India appears to be a real 'panacea' of Ayurvedic medicine because of its ability to support both immunity and liver function as well as resistance to stress through its adaptogen properties.

This supplement is part of our Immunity category.

Guduchi: Appearance and Ayurvedic Uses

Guduchi is a vine native to the sub-Indian continent, especially dry forests in tropical regions. Recognizable by its heart-shaped leaves, its branches twine around the small neem or mango trees that cross its path.

Though little-known in the West, guduchi is widely-revered in India where it is considered a star of the Ayurvedic pharmacopoeia. Its Sanskrit name, 'amrit', means 'that which protects' or 'immortal' (1).

In Ayurveda, it is normal to use the whole dried plant – stem, leaves and roots – for preparing decoctions or extracting oil. It is considered a rasayana (rejuvenating) remedy, conducive to revitalization of the mind and body. Indian herbalists traditionally recommend it for biostimulation of the immune defenses and physical and mental regeneration.

What are Guduchi’s Benefits for Health?

Guduchi has an abundance of bioactive compounds which account for its broad spectrum of action. Amongst others, it contains alkaloids (berberine, choline...), diterpenoid lactones, glycosides, steroids, sesquiterpenoids, phenolic compounds, and polysaccharides (2).

  • Guduchi and immunity. A number of studies have reported on the ability of guduchi, especially its valuable polysaccharides, to modulate the immune response through various mechanisms: activation of macrophages, regulation of interleukin secretion, and stimulation of lymphocytes (3-8).
  • Guduchi and oxidation. Guduchi has strong antioxidant potency. Studies have reported its ability to trap free radicals such as superoxide anion (O2-), hydroxyl radical (OH), NO radical and peroxynitrite anion (ONOO-), excess numbers of which can threaten cellular integrity (9).
  • Guduchi and blood sugar control. Together, the plant’s various active ingredients (alkaloids, flavonoids, saponins, steroids...) are thought to have a positive effect in regulating carbohydrate metabolism by reducing oxidative stress, harmonizing the release of the pancreatic hormone and preventing the formation of new sugars (gluconeogenesis) (10-11).
  • Guduchi and the liver. While the species Tinospora crispa has been described as hepatotoxic, Tinospora cordifolia is believed to be able to support liver detoxification processes. One study explored its liver-protective nature in rats contaminated with cadmium (a heavy metal) (12-13).
  • Guduchi and stress. Like Indian ginseng (ashwagandha), guduchi is part of the large group of adaptogen plants, ie, those able to improve the body’s resistance to various physical, chemical, or biological stressors (14). Interestingly, this botanical species displays extraordinary resilience, being able to withstand a lack of water, soil, etc.

Why Choose our Guduchi Supplement?

SuperSmart’s Guduchi supplement contains Tinofend®, a guduchi extract marked out by the standardization of its active principles (5% bitters and 20% polysaccharides), which is not the case with most guduchi powders or extracts.

In addition to the above-mentioned benefits, Tinofend® was positively noted in a study on the relief of allergic symptoms (15).

What is the Correct Dose for this Guduchi Supplement, Extracted from Tinospora Cordifolia?

Our Guduchi supplement contains 450 mg of guduchi extract per capsule. To benefit from its many effects, the recommended dose is 2 capsules a day with a glass of water (a daily dose of 900 mg).

3 Synergistic Supplements that can be Combined with Guduchi

Alongside your guduchi supplement, you can take a Japanese mushroom extract that is also rich in polysaccharides (specifically proteoglycans) and has been widely studied in the field of immunology: Maitake (17).

In terms of plant extracts, you can benefit from a synergy between guduchi and Ginseng. This key plant of traditional Chinese medicine is known for supporting the immune system and vitality (18).

If you are taking Guduchi more for allergy relief, you can combine it with Liposomal Quercetin, which many studies have suggested has potential anti-allergy (anti-inflammatory and antihistamine) effects (19-20).

Guduchi Supplementation: Any Side-Effects?

According to current studies, there are no major side-effects associated with taking guduchi. When taken for extended periods, constipation may occur in those with naturally slow transit (16).

Since guduchi can affect blood glucose levels, diabetics and anyone suffering from blood sugar disorders should consult their doctor before supplementing. Guduchi supplements are not recommended for children, or for women who are pregnant or breastfeeding without medical advice.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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