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Welcome Shop by health concern Anti-aging Spermidine
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A key molecule which helps to optimize autophagy and hold back aging

  • Supplement containing spermidine, a substance that helps extend lifespan.
  • Promotes autophagy (the process of cleaning out and regenerating cells).
  • Positive effects on cardiovascular health.
  • Helps prevent corruption of cells.
  • Cellular spermidine levels fall dramatically with age.
  • High quality, 100% vegan, additive-free supplement, made from standardized rice extract.
  • Provides an intake of 3mg spermidine a day (the highest amount on the market).
60 Veg. Caps
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Spermidine is an excellent spermidine supplement developed by SuperSmart, pioneers in supplementation in Europe.

With each passing year, the body’s cellular spermidine levels fall inexorably (1). It’s one of the markers of aging. By taking this supplement, you can significantly increase your intake of spermidine in a totally natural and healthy way.

Spermidine is known to help activate autophagy, a powerful cell detoxification mechanism. In particular, it has positive effects on cardiovascular health and helps combat deviant cell behavior. This anti-aging compound thus plays an active part in fighting aging and extending lifespan (2-3).

What exactly is spermidine?

Spermidine is a polyamine, an organic compound with several amine functions. It is present in all living beings. Formed by putrescine, spermidine is a precursor of spermine.

Spermidine actually gets its name from the fact that it was first discovered in human sperm in 1678. However, it is found in all human cells and in all those of mammals in general, as well as in various foods.

Dietary sources of spermidine

Small amounts of spermidine are found in foods such as soya beans, wheat germ, mushrooms and mature cheeses.

The benefits of the supplement Spermidine

The benefits of the supplement Spermidine

With age, there is an irreversible decline in intracellular levels of spermidine. This supplement enables you to significantly and naturally increase your intake of spermidine. Quite simply, it offers the the best quality and highest content of spermidine on the market.

Let’s now focus on the benefits of this compound. Various studies have shown that spermidine helps to regulate autophagy(4-5). This cleaning out and recycling process removes damaged or toxic proteins and organelles from cells (6-7). Autophagy, which is essential for protecting the body against all kinds of problems, becomes less effective as we get older. Increasing your intake of spermidine, levels of which also decline with age, helps to reactivate this autophagy mechanism (8).

Spermidine has been shown to help extend life lifespan in various invertebrate models (yeasts, worms, flies) and in human immune cells, by directly inhibiting acetyltransferases, and by maintaining histone H3 in a hypoacetylated state (9).

In particular, it helps to improve blood pressure and cardiac function. A number of observational studies have shown that intake of dietary spermidine is inversely associated with cardiovascular problems (9-11). It also helps to prevent cells from becoming corrupted, has anti-inflammatory properties, neuroprotective effects and plays a role in preventing the decline in stem cells (12-13).

Spermidine has also shown positive effects against glycation. This process, whereby sugars attach to proteins, is a factor in accelerated aging of tissues (14).

Finally, recent research has shown that diets rich in spermidine are associated with increased longevity in humans (15-16). In short, taking spermidine helps to support good general health, slow down aging and extend life expectancy.

How should this spermidine supplement be taken?

To obtain maximum benefit from this highly effective aging regulator, you need to take just 1 or 2 capsules of Spermidine a day. Each capsule contains 150 mg of rice extract standardized to 1% spermidine, providing a daily dose of 3 mg of spermidine.

Advice on how to hold back the aging process

If you’re looking for ways to slow down the rate at which your body is aging, here are some key tips to help you stay younger for longer:

  • take moderate exercise. To maintain healthy arteries and combat aging of the heart, you should aim to engage in physical activity (walking, cycling, yoga, housework, gardening …) four or five times a week;
  • keep yourself well-hydrated ! As we age, our skin tends to dehydrate. So to reduce the appearance of wrinkles as much as possible, drink a liter and a half of fluid a day (water, tea, herbal tea ...) and use a suitable moisturiser on your skin;
  • preserve your memory. To maintain mental ability, you need to keep your brain active by engaging in activities such as crosswords, boardgames, reading, watching films, recalling celebrities’ names, using memory-boosting apps, etc. ;
  • reduce pro-oxidant factors by limiting your consumption of barbecued food, charcuterie, fried food, fizzy drinks and alcohol, as well as avoiding smoking and exposure to UV rays … Excessive free radical release causes oxidative stress which accelerates cellular aging;
  • get enough sleep. A lack of sleep can lead to enlarged blood vessels in the brain, which causes a drop in cerebral blood pressure and thus an acceleration in cognitive decline. While we vary in the amount of sleep we need, aim for at least 7 hours a night to help slow down the aging process.

Other supplements that act synergistically with Spermidine

Alongside a course of spermidine, we recommend taking our famous supplement Senolytic Complex, formulated to eliminate senescent cells, one of the key cause of aging. This unique formulation contains fisetin, nicotinamide mononucleotide, bromelain, quercetin, black tea ... it is, in short, an amazing supplement combining the best nutrients in this field.

You could also increase your intake of pyrroloquinoline quinone (PQQ), a very specific molecule that helps to regenerate mitochondria, the powerhouses of the body’s cells. We recommend taking Mitochondrial Formula, an anti-aging supplement that contains two other highly effective compounds: lipoic acid and carnitine.

Daily dose: 2 capsules
Number of doses per pack: 30

per dose

Spermidine (derived from 300mg of rice extract standardized to 1% spermidine) 3 mg
Other ingredients: acacia gum, white rice flour.
Directions for use
Adults. Take 1 or 2 capsules a day. Each capsule contains 150mg of rice extract standardized to 1% spermidine.
No reviews for this product yet
  1. Minois, N., D. Carmona-Gutierrez, and F. Madeo. 2011. Polyamines in aging and disease. Aging 3 (8):716–32. doi: 10.18632/aging.100361.
  2. Eisenberg, Tobias, Heide Knauer, Alexandra Schauer, Sabrina Buttner, Christoph Ruckenstuhl, Didac Carmona-Gutierrez, Julia Ring, Sabrina Schroeder, Christoph Magnes, Lucia Antonacci, et al. 2009. Induction of autophagy by spermidine promotes longevity. Nature Cell Biology 11 (11):1305–14. doi: 10.1038/ncb1975.
  3. T.J. LaRocca, R.A. Gioscia-Ryan, C.M. Hearon Jr., D.R. Seals, The autophagy enhancer spermidine reverses arterial aging, Mech. Ageing Dev. 134 (2013) 314–320, https://doi.org/10.1016/j.mad.2013.04.004.
  4. T.J. LaRocca, R.A. Gioscia-Ryan, C.M. Hearon Jr., D.R. Seals, The autophagy enhancer spermidine reverses arterial aging, Mech. Ageing Dev. 134 (2013) 314–320, https://doi.org/10.1016/j.mad.2013.04.004.
  5. J. Fan, X. Yang, S. Jia, S. Kou, Y. Yang, et al., Spermidine coupled with exercise rescues skeletal muscle atrophy from D-gal-induced aging rats through enhanced autophagy and reduced apoptosis via AMPK-FOXO3a signal pathway, Oncotarget 8 (2017) 17475–17490, https://doi.org/10.18632/oncotarget.15728.
  6. M. Filfan, R.E. Sandu, A.D. Zavaleanu, A. GresiTa, D.G. Glavan, et al., Autophagy in aging and disease, Rom. J. Morphol. Embryol. 58 (2017) 27–31.
  7. B. Levine, G. Kroemer, Autophagy in the pathogenesis of disease, Cell 132 (2008) 27–42, https://doi.org/10.1016/j.cell.2007.12.018.
  8. A. Bhukel, F. Madeo, S.J. Sigrist, Spermidine boosts autophagy to protect from synapse aging, Autophagy 13 (2017) 444–445, https://doi.org/10.1080/15548627.2016.1265193.
  9. Eisenberg, Tobias, Heide Knauer, Alexandra Schauer, Sabrina Buttner, Christoph Ruckenstuhl, Didac Carmona-Gutierrez, Julia Ring, Sabrina Schroeder, Christoph Magnes, Lucia Antonacci, et al. 2009. Induction of autophagy by spermidine promotes longevity. Nature Cell Biology 11 (11):1305–14. doi: 10.1038/ncb1975.
  10. Eisenberg, Tobias, Mahmoud Abdellatif, Sabrina Schroeder, Uwe Primessnig, Slaven Stekovic, Tobias Pendl, Alexandra Harger, Julia Schipke, Andreas Zimmermann, Albrecht Schmidt, et al. 2016. Cardioprotection and lifespan extension by the natural polyamine spermidine. Nature Medicine 22 (12):1428–38. doi: 10.1038/nm.4222.
  11. Soda, K., Y. Kano, and F. Chiba. 2012. Food polyamine and cardiovascular disease – An epidemiological study. Global Journal of Health Science 4 (6):170–8. doi: 10.5539/gjhs.v4n6p170.
  12. Pietrocola F, Castoldi F, Kepp O, Carmona-Gutierrez D, Madeo F, Kroemer G. Spermidine reduces cancer-related mortality in humans. Autophagy. 2019;15(2):362-365. doi:10.1080/15548627.2018.1539592
  13. F. Madeo, T. Eisenberg, F. Pietrocola, G. Kroemer, Spermidine in health and disease, Science 359 (2018) 1–10, https://doi.org/10.1126/science.aan2788.
  14. Gugliucci A, Menini T. The polyamines spermine and spermidine protect proteins from structural and functional damage by AGE precursors: a new role for old molecules? Life Sci. 2003 Apr 25;72(23):2603-16. doi: 10.1016/s0024-3205(03)00166-8. PMID: 12672506.
  15. Kiechl, Stefan, Raimund Pechlaner, Peter Willeit, Marlene Notdurfter, Bernhard Paulweber, Karin Willeit, Philipp Werner, Christoph Ruckenstuhl, Bernhard Iglseder, Siegfried Weger, et al. 2018. Higher spermidine intake is linked to lower mortality: A prospective population-based study. The American Journal of Clinical Nutrition 108 (2):371–80. doi: 10.1093/ajcn/nqy102.
  16. T. Eisenberg, M. Abdellatif, A. Zimmermann, S. Schroeder, T. Pendl, et al., Dietary spermidine for lowering high blood pressure, Autophagy 13 (2017) 767–769, https://doi.org/10.1080/15548627.2017.1280225.

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