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What exactly is berberine? Produced by plants such as the common barberry (Berberis vulgaris), berberine is a natural alkaloid which has long been used in Chinese and Ayurvedic medicine and has been widely studied for its properties and health benefits. Research shows berberine to be particularly beneficial for type II diabetics, as it helps to lower blood glucose levels. Some studies also suggest it improves the lipid profile in cases of hyperlipidaemia – in other words, it may have a positive effect on high levels of lipids in the blood such as cholesterol and triglycerides. These findings are significant since high blood cholesterol is a risk factor for cardiovascular disease.
How does berberine work? Its mechanism of action is essentially one of regulating AMPK (Adenosine Monophosphate-activated Protein Kinase). This enzyme plays a fundamental role in the body, helping to both normalise energy metabolism, and regulate food intake and tissue sensitivity. It is therefore key to certain metabolic diseases such as diabetes and its complications, as well as to insulin resistance and obesity.
In activating AMPK, berberine acts at various levels:
How effective is berberine? Its beneficial properties make it comparable to metformin, a drug widely used to treat type II diabetes and excess weight associated with glucose metabolism. As described in Nutranews, the most significant studies are those comparing the efficacy of berberine and metformin in type II diabetics, with or without dyslipidaemia. Berberine has been found to be particularly effective at activating AMPK, so reducing blood glucose levels. Hence the inclusion of a natural extract of berberine in the formation of AMPK Booster, a powerful and innovative formulation for metabolic disorders.
What is the recommended dose? Berberine is available as a dietary supplement in the form of 500mg tablets. According to research conducted on this natural alkaloid, the average recommended daily amount varies between 1000mg and 1500mg, divided into two or three doses to be taken before the main meals of the day. In order to benefit fully from berberine supplementation, it should be taken for at least three months, as its optimal activity is only apparent after two weeks’ regular use. Apart from a few reported cases of mild, temporary constipation immediately after beginning supplementation, berberine is free from side-effects. You may also be interested in other dietary supplements that help combat the negative effects of excess carbohydrates in the diet. The compounds in the formulation Carbo Defense™, for example, can help regulate carbohydrate metabolism by restricting sugar absorption in the small intestine. For its part, Carnosine has a beneficial effect against glycation, a reaction that occurs in hyperglycaemia and which contributes to accelerated ageing.
|Daily dose : 2 tablets
Number of doses per box : 30
|Amount per dose|
|Berberine (from 1040 mg Berberis vulgaris extract standardised to 97 % berberine)||1 000 mg|
|Other ingredients : magnesium stearate, microcrystalline cellulose, croscarmellose sodium, silicon dioxide, hydroxypropyl methyl cellulose, glycerol.|
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