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Astragaloside IV Supplement
Astragaloside IV Supplement
0603Astragaloside IV SupplementSize
Sans nano-particulesSans glutenVegan
Astragaloside IV
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Best if used before 03/30/2023

Astragaloside IV is an astragalus root extract with anti-aging properties.

  • Has antioxidant, immune-stimulant and anti-inflammatory properties.
  • Recognized for its ability to activate telomerase, which slows down the shortening of telomeres, and extends cell lifespan.
  • Combats cellular aging and the development of age-related diseases.
: 63.48 $, save $5.52 (8%)
: 63.48 $, save $5.52 (8%)
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60 Veg. Caps
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Small glass jar with yellow Astragalus oil

Astragalus Root Extract Supplement

Astragaloside IV is a supplement designed to combat aging, but that also has several reported beneficial properties, particularly immunostimulant, anti-inflammatory, antioxidant and anti-glycation. Its exceptional properties are due to astragaloside root extract's specific ability to activate telomerase, thus slowing down the shortening of telomeres and extending cell lifespan. The shortening of telomeres is associated with cellular aging and the development of age-related diseases.

What is the relationship between Astragalus membranaceus root extract and Astragaloside IV?

What is astragaloside IV and how does it relate to an astragalus root extract supplement? Astragaloside IV is present in minute amounts in the root of astragalus (Astragalus membranaceus), a plant that was particularly popular in traditional Chinese medicine.

Through a highly complex and expensive process, it is extracted and concentrated in order to obtain an active amount. Astragalus root has been used for centuries as a tonic and to combat a wide range of discomforts in an effort to increase feelings of wellness and to support the ability to reduce illness.

What is Telomerase and how does it relate to Astragalus root extract?

The connection between telomerase and astragalus root is astragaloside IV, the isolated chemical that is extracted from Astragalus membranaceus. Studies have found evidence that the chemical is shown to affect the regulation of telomerase activity.

Telomerase is an enzyme that is active in gametes, stem, and tumor cells and is responsible for the maintenance and length of telomeres — the end of a chromosome — by adding guanine-rich repetitive sequences to the end of the chromosome.

The function of telomerase in health requires more analysis and study, but what is known is that as DNA polymerase is not fully capable of copying DNA at the very end of chromosomes, and roughly 50 nucleotides are lost during each cell cycle, this results in telomere length shortening.

Cells with critically short telomeres deteriorate and eventually die.

Telomerase therapeutics are not currently approved for clinical use but are being studied for their potential to combat malignancies and increase the viability of cells for therapeutic purposes.

For example, Telomere length maintenance includes both the opportunity to activate telomere maintenance that can revert telomere shortening and increase the lifespan of a few target cells.

What are the benefits associated with Astragaloside IV capsules?

Astragalus root extract contains a series of cycloartane glycosides called astragalosides I to VII. The most widely studied of these, in Chinese and European research centers, is astragaloside IV.

Studies suggest, amongst others, it has the following properties:

  • Immunostimulant: Studies on astragalus root and immune response show that it acts through several different pathways, especially by increasing the number of stem cells in the spinal cord and lymphatic tissue and encouraging them to develop into active immune cells, and by stimulating the production of immunoglobulins and macrophages.
  • Anti-inflammatory: Studies on astragaloside IV and anti-inflammation found it potentially inhibited inflammasome activation in mice. Additionally, astragalus oral solutions were found to stem inflammation of the airways in those with chronic inflammatory issues.
  • Antibacterial: as demonstrated by in vitro studies on Shigella dysenteriae, Streptococcus haemolyticus, Diplococcus pneumoniae and Staphylococcus aureus.
  • Antioxidant: studies demonstrate it may inhibit lipid peroxidation by 40% in vitro. These antioxidant properties may go some way to explaining its cardio and neuroprotective effects.
  • Cardioprotective: with studies highlighting health benefits for patients with congestive cardiac insufficiency and angina pectoris, astragalus extracts have a cardiotonic effect.
  • Neuroprotective: in traditional Chinese medicine, astragalus root extract is used to treat neurodegenerative diseases. One study demonstrated the capacity of astragaloside IV to protect dopaminergic neurons, the degeneration of which can lead to more serious illnesses.

All of these potential astragalus root benefits are impressive and compel healthy individuals to do more research. However, more research is required to understand all the potential astragalus extract benefits.

Telomere shortening is currently one of the most widely studied areas of anti-aging medicine. In addition to our astragaloside supplement, there are several other natural active principles available to buy at Supersmart that have been identified for their ability to protect telomeres or stimulate telomerase.

Two such supplements are cycloastragenol, and resveratrol.

Other beneficial compounds, such as vitamins C and E, carnosine, and several natural antioxidants, have also been included in the enhanced formulation Telomeres Maintenance Formula.

The shortest telomeres have been observed in octogenarians. Research suggests that individuals aged 60 or older with the shortest telomeres appear to be at a significantly higher risk of death from serious health conditions. However, studies show that stimulating telomerase may increase cell lifespan.

What should you know about Astragaloside IV Side effects?

After learning all the potential astragaloside IV benefits, you may feel compelled to take it as a supplement. However, you should always research the astragalus contraindications before starting.

It’s best to discuss the potential astragalus root extract side effects with a healthcare professional before starting any new supplement regimen.

If you are taking any other medications, supplements, or over-the-counter medicines, you need to make sure they won’t negatively react with an astragaloside IV supplement. Additionally, if you are looking at taking astragalus supplements to soothe discomfort and swelling, you should verify your current health conditions won't be exacerbated by them, especially if you are taking anything to suppress the immune system. Only a qualified health professional can tell you if a new supplement is right for you.

Until more studies are performed, it's not recommended to take an astragalus root extract supplement while you are pregnant or breastfeeding. Additionally, the use of these supplements is intended for healthy adults only. They should never be given to or be within the reach of children or pets.

There is always the chance that you will experience side effects once you start taking Astragaloside IV 98%. If that occurs, stop using the supplement immediately and seek medical help from a qualified physician. Only after a healthcare professional has cleared you to restart your supplement regimen should you take any more.

Daily dose : 2 capsules
Number of doses per pack : 30
Amount per dose
Astragaloside IV 98% 100 mg
Other ingredients : Acacia gum, rice flour.
Directions for use

How To Take Astragalus Root Capsules

There may also be astragalus benefits for skin. If you want to take astragalus root for younger-looking skin, to reduce swelling, and for the reported astragalus membranaceus benefits, you must know the appropriate way to take it. For most healthy adults, it's recommended to take one to two capsules each day. However, your physician might recommend a different dosage based on your needs.

If you take two capsules each day, this bottle will last thirty days, providing a month's supply. Each capsule contains 50 mg of astragaloside IV, along with rice flour and acacia gum. There are no further ingredients added to our capsules, ensuring you only consume high-quality products.

At this time, there isn't enough evidence present to recommend taking both astragaloside IV and Resveratrol Synergy together. Some people take their daily astragaloside serving in the morning, with a capsule of Resveratrol Synergy at lunch and another in the evening. Other people choose to alternate the products, taking one on a particular day and switching the next, or weekly alternating schedules.

Some customers choose to take a break from supplementation either every other month or every three months, while some do not. You must choose the appropriate serving for you based on what your healthcare provider recommends.

Additionally, you should store your supplements in a cool, dry location. Make sure they remain out of direct sunlight and always dispose of supplements that have reached their "best by" date. Combine our astragalus supplement with a healthy lifestyle and balanced diet to achieve the best results.

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  1. Ma X, Jiang Y, Wen J, Zhao Y, Zeng J, Guo Y. A comprehensive review of natural products to fight liver fibrosis: Alkaloids, terpenoids, glycosides, coumarins and other compounds. Eur J Pharmacol. 2020;888:173578. doi:10.1016/j.ejphar.2020.173578
  2. Yung LY, Lam WS, Ho MK, et al. Astragaloside IV and cycloastragenol stimulate the phosphorylation of extracellular signal-regulated protein kinase in multiple cell types. Planta Med. 2012;78(2):115-121. doi:10.1055/s-0031-1280346
  3. Zvereva MI, Shcherbakova DM, Dontsova OA. Telomerase: structure, functions, and activity regulation. Biochemistry (Mosc). 2010;75(13):1563-1583. doi:10.1134/s0006297910130055
  4. Gomez DE, Armando RG, Farina HG, et al. Telomere structure and telomerase in health and disease (review). Int J Oncol. 2012;41(5):1561-1569. doi:10.3892/ijo.2012.1611
  5. Aragona M, Maisano R, Panetta S, et al. Telomere length maintenance in aging and carcinogenesis. Int J Oncol. 2000;17(5):981-989. doi:10.3892/ijo.17.5.981
  6. Qin Q, Niu J, Wang Z, Xu W, Qiao Z, Gu Y. Astragalus embranaceus extract activates immune response in macrophages via heparanase. Molecules. 2012;17(6):7232-7240. Published 2012 Jun 13. doi:10.3390/molecules17067232
  7. Tang B, Tang WJ, Tang YH, Deng CQ. Sheng Li Xue Bao. 2019;71(3):424-430.
  8. Wang W, Jing W, Liu Q. Astragalus Oral Solution Ameliorates Allergic Asthma in Children by Regulating Relative Contents of CD4+CD25highCD127low Treg Cells. Front Pediatr. 2018;6:255. Published 2018 Sep 20. doi:10.3389/fped.2018.00255
  9. Sharifi-Rad M, Pohl P, Epifano F, Álvarez-Suarez JM. Green Synthesis of Silver Nanoparticles Using Astragalus tribuloides Delile. Root Extract: Characterization, Antioxidant, Antibacterial, and Anti-Inflammatory Activities. Nanomaterials (Basel). 2020;10(12):2383. Published 2020 Nov 29. doi:10.3390/nano10122383
  10. Hong CY, Lo YC, Tan FC, Wei YH, Chen CF. Astragalus membranaceus and Polygonum multiflorum protect rat heart mitochondria against lipid peroxidation. Am J Chin Med. 1994;22(1):63-70. doi:10.1142/S0192415X94000085
  11. Liu C, Huang Y. Chinese Herbal Medicine on Cardiovascular Diseases and the Mechanisms of Action. Front Pharmacol. 2016;7:469. Published 2016 Dec 1. doi:10.3389/fphar.2016.00469
  12. Li H, Shi R, Ding F, et al. Astragalus Polysaccharide Suppresses 6-Hydroxydopamine-Induced Neurotoxicity in Caenorhabditis elegans. Oxid Med Cell Longev. 2016;2016:4856761. doi:10.1155/2016/4856761

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Astragaloside IV
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