0
en
US
Free Shipping on Orders Above $45
X
× SuperSmart Shop by health concern Shop by product Bestsellers New products Promotions My account Smart Prescription Blog Loyalty program Language: English
Welcome Shop by health concern Anti-aging L-Serine
New
L-Serine
L-Serine
Size
Illustration
0804L-SerineSizeL-Serine
×
+
-
L-Serine
Anti-aging
0
No reviews
Reviews
$29.00
New
Limited quantity
Description
A promising amino acid for preserving and restoring memory
  • Amino acid essential for healthy function of the central nervous system .
  • Precursor of D-serine which activates the NMDA neuronal receptors necessary for learning and memorisation.
  • Also boosts T lymphocyte levels.
  • Precursor of other important amino acids: glycine, cysteine...
-
+
60 tabs
Add To Cart
Wish list
L-Serine

L-Serine

L-Serine is a high-quality dietary supplement composed of L-serine. This amino acid fulfillls multiple functions in the body: it helps ensure the central nervous system (1) , immune system (2) and muscular system (3) function normally, and is converted into D-serine to activate specific receptors in the brain(4), etc. L-serine is also a precursor of other amino acids used by the body.

What exactly is L-serine?

L-serine is an α-amino acid with the chemical formula C3 H7 NO3. This organic compound was first isolated in 1865. Discovered in extracts of silkworm cocoon, L-serine, or simply ‘serine’, gets its name from the Latin sericum meaning ‘ silk’.

Where is this amino acid found?

Serine is synthesised by the body from vitamins B3, B6 and folic acid ... Astrocytes (the cells responsible for protecting neurons) are, for example, known to produce L-serine. A certain amount is also found in dietary protein: meat, fish, eggs, dairy products, grains (5)...

What functions does serine perform in the body?

Illustration of the benefits of L-serine for NMDA receptors

L-serine plays a role in many important biochemical processes:

  • it participates in the synthesis of proteins, nucleotides and neurotransmitters (6);
  • it is also the precursor of D-serine which directly contributes to the brain’s neuronal and synaptic plasticity(7-10). D-serine acts as a gliotransmitter in the hippocampus by binding to the brain’s NMDA receptors which are essential for learning and memorising (11-13);
  • serine is involved in forming cell membranes and myelin (the protective sheath surrounding nerves) (14);
  • it supports a healthy immune system, primarily by increasing the number of T lymphocytes in the body (15);
  • it participates in the development of muscle mass and promotes post-exercise recovery (16);
  • it is associated with the formation of purines and pyrimidines, compounds essential to the life of cells;
  • it is also a precursor of other amino acids (glycine, cysteine, tryptophan...) and various metabolites (sphingolipids, folates...)

What benefits are offered by the supplement L-Serine?

Supplementation provides a substantial intake of L-serine. This product is formulated to deliver 2000 mg of serine a day, consistent with the doses recommended in current studies.

Recent research suggests that supplementing with L-Serine is an effective way of helping to preserve and restore memory. A French study that investigated mice with degenerative disorders, published in the journal Cell Metabolism, has attracted significant scientific interest. As we know, certain neurodegenerative problems are associated with a decrease in energy metabolism. This causes astrocytes to consume less glucose and as a result, they produce less L-serine (and thus D-serine). Without D-serine to stimulate NMDA receptors, neuronal plasticity and memorisation capacity decrease.

This study demonstrated that dietary intake of L-serine successfully restored spatial memory in mice with degenerative problems. In short, it suggests that supplementation with L-serine, as an adjunct to drug therapy, may help combat changes in cerebral metabolism.

How should this supplement be taken?

An adequate dose of L-Serine is 2 tablets a day, ideally taken in between meals. This supplement is not recommended for women who are pregnant or breastfeeding, or for children. As always, we recommend you consult your doctor before starting any course of supplements, especially if you are on any medication.

Tips for maintaining your cognitive faculties and memory

If you’re keen to preserve your cognitive function and especially your memory, here’s some simple advice that will help you activate your neurons effectively. Try to:

  • engage in regular mental stimulation by doing puzzles or playing strategy games, for example, (crosswords, scrabble, chess, card games ...) (17) ;
  • maintain your memory by trying to remember the names of books, actors, capital cities, etc. Come up with your own mnemonic devices: it’s much easier to remember something when you use visual association. Memory is a ‘muscle’ which can be trained (18);
  • get enough sleep because it is at night that our neurons organise and consolidate information processed during the day. A succession of bad nights can make it hard to keep track of your memories (19) ;
  • take exercise to oxygenate your brain. Memory also benefits from physical activity when it comes to sorting through knowledge (20);
  • avoid drinking too much alcohol as it can damage neurons and cause problems with attention and memory in the long term (21).

Supplements to take in conjunction with L-Serine

Are you looking for other supplements that will complement L-Serine in helping you improve and protect your memory? Why not try the excellent brain-health nutrient DMAE, obtained from a molecule found naturally in oily fish. There’s also Noopept, a supplement composed of the famous stimulating substance NeuraSharp™. This supplement offers powerful neuroprotective effects.

Composition
Daily dose: 2000 mg
Number of doses per pack: 30

Amount
per dose

L-serine 2000 mg
Other ingredients: acacia gum.
Directions for use

Adults. Take 2 tablets a day.

Each tablet contains 1000 mg of L-serine.

No reviews for this product yet
0
References
  1. Tabatabaie L, Klomp LW, Berger R, de Koning TJ. L-serine synthesis in the central nervous system: a review on serine deficiency disorders. Mol Genet Metab. 2010;99(3):256-262. doi:10.1016/j.ymgme.2009.10.012
  2. Ma EH, Bantug G, Griss T, et al. Serine Is an Essential Metabolite for Effector T Cell Expansion [published correction appears in Cell Metab. 2017 Feb 7;25(2):482]. Cell Metab. 2017;25(2):345-357. doi:10.1016/j.cmet.2016.12.011
  3. Gheller B, Blum J, Thalacker-Mercer A. Serine and Glycine Are Essential for Human Muscle Progenitor Cell P Roliferation (P08-063-19). Curr Dev Nutr. 2019;3(Suppl 1):nzz044.P08-063-19. Published 2019 Oct 24. doi:10.1093/cdn/nzz044.P08-063-19
  4. Le Douce J, Maugard M, Veran J, et al. Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer's Disease. Cell Metab. 2020;31(3):503-517.e8. doi:10.1016/j.cmet.2020.02.004
  5. http://www.tiem.utk.edu/~gross/bioed/webmodules/aminoacid.htm
  6. Tabatabaie L, Klomp LW, Berger R, de Koning TJ. L-serine synthesis in the central nervous system: a review on serine deficiency disorders. Mol Genet Metab. 2010;99(3):256-262. doi:10.1016/j.ymgme.2009.10.012
  7. Wolosker H, Dumin E, Balan L, Foltyn VN. D-amino acids in the brain: D-serine in neurotransmission and neurodegeneration. FEBS J. 2008;275(14):3514-3526. doi:10.1111/j.1742-4658.2008.06515.x
  8. Metcalf JS, Dunlop RA, Powell JT, Banack SA, Cox PA. L-Serine: a Naturally-Occurring Amino Acid with Therapeutic Potential. Neurotox Res. 2018;33(1):213-221. doi:10.1007/s12640-017-9814-x
  9. Hirabayashi Y, Furuya S. Roles of l-serine and sphingolipid synthesis in brain development and neuronal survival. Prog Lipid Res. 2008;47(3):188-203. doi:10.1016/j.plipres.2008.01.003
  10. El-Hattab AW, Shaheen R, Hertecant J, et al. On the phenotypic spectrum of serine biosynthesis defects. J Inherit Metab Dis. 2016;39(3):373-381. doi:10.1007/s10545-016-9921-5
  11. Le Douce J, Maugard M, Veran J, et al. Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer's Disease. Cell Metab. 2020;31(3):503-517.e8. doi:10.1016/j.cmet.2020.02.004
  12. http://www.cnrs.fr/fr/alzheimer-un-acide-amine-pour-aider-restaurer-la-memoire
  13. https://lejournal.cnrs.fr/articles/un-nouveau-regime-pour-freiner-alzheimer
  14. Wang G, Ding L, Gao C, et al. Neuroprotective effect of l-serine against white matter demyelination by harnessing and modulating inflammation in mice. Neuropharmacology. 2019;146:39-49. doi:10.1016/j.neuropharm.2018.11.025
  15. Ma EH, Bantug G, Griss T, et al. Serine Is an Essential Metabolite for Effector T Cell Expansion [published correction appears in Cell Metab. 2017 Feb 7;25(2):482]. Cell Metab. 2017;25(2):345-357. doi:10.1016/j.cmet.2016.12.011
  16. Gheller B, Blum J, Thalacker-Mercer A. Serine and Glycine Are Essential for Human Muscle Progenitor Cell P Roliferation (P08-063-19). Curr Dev Nutr. 2019;3(Suppl 1):nzz044.P08-063-19. Published 2019 Oct 24. doi:10.1093/cdn/nzz044.P08-063-19
  17. Butcher J. Mind games: do they work?. BMJ. 2008;336(7638):246-248. doi:10.1136/bmj.39462.534630.AD
  18. Al-Thaqib A, Al-Sultan F, Al-Zahrani A, et al. Brain Training Games Enhance Cognitive Function in Healthy Subjects. Med Sci Monit Basic Res. 2018;24:63-69. Published 2018 Apr doi:10.12659/msmbr.909022
  19. Rasch B, Born J. About sleep's role in memory. Physiol Rev. 2013;93(2):681-766. doi:10.1152/physrev.00032.2012
  20. Hedayati M, Sum S, Hosseini SR, Faramarzi M, Pourhadi S. Investigating the effect of physical games on the memory and attention of the elderly in adult day-care centers in Babol and Amol. Clin Interv Aging. 2019;14:859-869. Published 2019 May 10. doi:10.2147/CIA.S196148
  21. White AM, Swartzwelder HS. Age-related effects of alcohol on memory and memory-related brain function in adolescents and adults. Recent Dev Alcohol. 2005;17:161-176. doi:10.1007/0-306-48626-1_8

Featured products

New
Daily 3® SupplementDaily 3® Multivitamin Supplement

The most complete multivitamin supplement you can take in a single capsule

$49.00
+
Lactobacillus Gasseri SupplementLactobacillus Gasseri Probiotic Supplement

A probiotic strain that’s particularly effective for weight control In gastroresistant DR Caps™ for optimum efficacy.

$21.00
+
H. Pylori Fight Supplement H. Pylori Fight

The natural treatment for Helicobacter pylori

$28.00
+
Melatonin SprayMelatonin Spray 1 mg

All the efficacy of prolonged-release melatonin in a convenient, metered-dose, sublingual spray.

$18.00
+
Berberine SupplementBerberine Supplement

A natural and powerful new weapon against type II diabetes

$32.00
+
New
Senolytic Complex Supplement Senolytic Complex

Senolytics: a revolutionary formula for destroying the senescent cells responsible for aging

$69.00
+
Vitamin D3 Supplement Vitamin D3 5000 IU

To help prevent the risks of vitamin D deficiency Fat-soluble vitamin in oil form = increased bioavailability

$18.00
+
Super Omega 3Super Omega 3

EPA and DHA: one of the most natural, pure, powerful and stable product on the market

$25.00
+
Newsletter
Subscribe to our newsletter
and obtain a 5% permanent discount
Our selection of articles
Anti-aging: senolytics, the best way to stay young

Do you want to delay the negative effects of aging and stay fit and healthy for as long as possible, to get the most out of life and time spent with loved ones? Discover senolytics, the ultimate weapon for fighting the aging process.

The multiple benefits of goji berries

A superfruit used for more than 2000 years in traditional Chinese medicine, the goji berry has become increasingly popular in the West because of its high content of vitamins and antioxidants. Discover its various benefits.

What exactly is calorie restriction?

Calorie restriction consists of reducing your food intake, compensating for any potential deficiencies by taking supplements. Aside from its slimming effects, calorie restriction is now being studied primarily for its ability to prolong life expectancy.

L-Serine
-
+
$29.00 Add To Cart
© 1997-2020 Fondation pour le Libre Choix. All rights reserved
© 1997-2020 Fondation pour le Libre Choix. All rights reserved
Nortonx
secure
Warning
ok