![Rhus succedanea leaves and pollen]( "Rhus succedanea")
Fisetin Supplement - Destroys Senescent Cells and Stimulates Autophagy
The Fisetin supplement is the most powerful senolytic supplement on the market. It’s part of the large family of natural polyphenols antioxidants, which include quercetin, kaempferol and myricetin.
It’s designed to eliminate senescent cells scattered throughout the body — rogue cells that have stopped contributing to essential functions and induce nearby healthy cells to join in the dysfunction. Important scientific studies have shown that these senescent cells are directly linked to aging and decline.
Fisetin also helps to activate autophagy. What is autophagy? It is the body’s mechanism for eliminating toxic elements that accumulate in cells. It was discovered by Professor Yoshinori Ohsumi, a finding for which he was awarded the Nobel prize in medicine in October 2016.
Autophagy literally means “self-eat.” That might sound scary, but it positively affects the body, under the right conditions. Autophagy is actually a method of self-preservation the body uses to remove bad cells while recycling parts for cleaning and cellular repair. It’s like your body hitting a reset button.
What is Fisetin?
Fisetin is a polyphenol found in fruits such as strawberries (160 mg/kg), apples (27mg/kg) and persimmon (10 mg/kg), as well as in some medicinal plants. It has multiple biological benefits, including the inhibition of cell proliferation, neuroprotection, bone protection and suppression of inflammation.
But it’s two most extraordinary properties are its ability to both destroy senescent cells that pervade the body and aid in activating autophagy, which enables cells to devour their own waste products. Several studies have shown it helps extend longevity and reduce markers of senescence in humans.
Its hydrophobic nature means it easily penetrates cells via the cell membrane. It then encourages the self-destruction of abnormal cells (such as senescent cells) by activating various characteristic proteins.
One of its main advantages over other senolytics is its ability to reduce the proportion of senescent immune cells (T lymphocytes and NK cells). Since immune cells are themselves important for cleaning out senescent cells, this makes fisetin even more effective. This study highlights its senolytic properties and impact on longevity: Fisetin is a senotherapeutic that extends health and lifespan.
It also helps cells to get rid of their toxic debris by eating it. This is the above-mentioned autophagy process. When this mechanism becomes disrupted — as a result of mutations, for example — it can lead to chronic diseases, such as cancer, as well as neurological diseases.
People looking to slow the aging process, improve brain health or boost the strength of bones often turn to fisetin for support. This well-researched supplement offers numerous benefits to the entire body.
The Link Between Fisetin and Aging
Fisetin is a rare product that acts on three key processes associated with aging: the increase in senescent cells, inactivation of the autophagy process, and the decline in neural communication. People looking to combat the aging process often turn to fisetin due to its well documented advantages.
How Senescent Cells Damage the Body and How Senotherapy Works
In 2014, there was a major scientific advance in the fight against aging: researchers identified totally depleted cells in the tissues of individuals over 40 years old.
Spread throughout the body’s tissues, these so-called senescent cells are defective, unable to fulfill their function. And, although they no longer work properly, they are not eliminated from the body and thus accumulate pathologically in the milieu, according to research.
Uncommon in young people, these senescent cells increase with age, particularly in adipose tissue, skeletal muscle, blood vessels, the brain, the kidneys and skin.
Unfortunately, senescent cells are not content to simply stay-put; they also impede the activity of neighboring healthy cells by continually releasing pro-inflammatory substances (IL-1, IL-6 and IL-8), vesicles and insoluble proteins (fibronectin, collagen) in the extracellular milieu.
But these substances don’t just signal to other cells the advanced state of deterioration they’re in; they affect the function of nearby healthy cells. And numerous studies have shown the number of senescent cells in the body is directly linked to the aging process and the development of age-related diseases.
Even a low level of senescent cells is enough to wreak havoc in healthy tissue and trigger a number of age-related health problems: systemic inflammation, arthritis, atherosclerosis, chronic diseases, sarcopenia, cataracts, insulin resistance, vascular hyporeactivity and more.
That brings us to senotherapy, an early-stage research field looking into the development of therapeutic agents and techniques that will target cellular senescence. Fisetin supplements are one of the options that show great promise in combating the negative effects of senescent cells.
Using Senolytics to Destroy Senescent Cells
Normally, when stimulated by the appropriate trigger, cells self-destruct to avoid damaging the body. This is called apoptosis, or programmed cell death, but in the case of senescent cells, this mechanism doesn’t work. Instead, they are left to parasitize the body and cause chaos all around them.
Fortunately, scientists have identified several compounds that are specifically able to repair this defective mechanism, thus reinstating appropriate self-destruction.
These extraordinary substances are called ‘senolytics’ and fisetin is the most powerful one. It enables the selective destruction of senescent cells in order to limit the severity of age-related diseases, increase resilience and longevity, and delay the effects of aging. It essentially provides complete clean-out benefits, allowing healthy cells to wrest back control and restore full function to the body.
Leveraging Autophagy To Prevent Healthy Cells From Turning Into Senescent Cells
A young, healthy cell is able to digest part of its contents —proteins, cell debris and microorganisms — if those contents impair its ability to function. This voluntary breakdown is called autophagy, and autophagy benefits include both the cleansing and recycling of senescent cells.
“This process is very important because if the cell is unable to self-clean, debris will accumulate,” explains Isabelle Vergne, a scientist at the French National Center for Scientific Research (CNRS) who studies autophagy. “If this process is unregulated, it can lead to a number of diseases,” she adds.
And according to Professor Ioannis Nezis of Warwick University in the UK, researchers are trying to “understand why this process declines with age and to find innovative ways of activating it in order to maintain our cells in a healthy state for longer and to be able to live a better, longer life.”
Professor Ohsumi, a recipient of the Nobel prize for medicine in 2016, succeeded in identifying the genes necessary for this, and he showed that in certain age-related disorders, such as diabetes, atherosclerosis and neurodegenerative diseases, it’s necessary to stimulate or even reactivate the autophagy process to help cells get rid of the protein aggregates that accumulate in them.
Fisetin is one of the substances that can stimulate autophagy, and Supersmart’s formula is standardized to 98 percent purity, making it one of the best fisetin supplements available.
Additional Fisetin Benefits
Fisetin supplement benefits go on. Among anti-aging supplements, few can compete with the number of benefits and qualities that studies show fisetin offers. Not only does it appear to kill off senescent cells and combat aging naturally; it can also be used to promote brain health and help preserve memory function. Here are a few specific ways fisetin helps boost your overall health:
Promotes Neuron Survival and Overall Brain Health
The brain is the most complicated organ in the body, but it’s also one of the most difficult to maintain, especially as you get older. Studies show that brain volume and weight decline by about five percent each decade after the age of 40, with the largest decreases happening after age 70.
As brain health declines, it’s possible to encounter several health issues, including neurodegenerative diseases, strokes and Parkinson’s disease. Neuron survival is the key to promoting better brain health.
This study shows that fisetin supplements can act as a substitute for neurotrophic factors. While some cells normally die within 24 hours, when fisetin is introduced, those cells are able to survive and produce long neurites. That same study indicates that fisetin enhances glutathione synthesis and increases proteasome activity. In essence, Senolytic supplements are the ultimate brain health supplements.
Preserves Memory Functionality
Numerous studies have shown fisetin helps improve memory and concentration and protect neurons and promotes their growth. Able to cross the blood-brain barrier, fisetin encourages neural communication in the hippocampus, the area of the brain associated with long-term memory.
Strengthens Bones in Those Aged 50+
As the body gets older, the bones begin to weaken naturally. Scientists are investigating fisetin’s potential for combating osteoporosis, a problem that affects more than 10 million Americans. This bone disorder significantly increases the risk of fractures and impairs the quality of life of those affected. And since conventional treatments often have adverse side-effects, natural alternatives have been well researched.
Studies show fisetin may act on bone remodeling, the result of activity by osteoblasts — bone-forming cells — and that of osteoclasts — bone-resorbing cells. In osteoporosis, an imbalance between the activity of these two types of cells gradually leads to an inadequate level of bone mineral density and changes in the micro-architecture of the bones. But fisetin has the ability to recalibrate bone remodeling by stimulating osteoblasts and blocking differentiation caused by osteoclasts’ activities.
In addition to aging, bone loss may stem from poor nutrition, immobility, certain medical treatments and reduced lean body mass. Chronic inflammatory diseases are often associated with bone loss as well.
Directions for use
Fisetin Dosage
Strawberries, apples, persimmons, lotus root, onions, grapes and kiwi contain small amounts of fisetin, However, taking a high-quality fisetin supplement may be necessary to ensure you get the right dosage.
Fisetin 500 mg can either be used once a year, as part of a three-monthly treatment plan or taken continuously, according to your needs. We recommend taking two capsules a day, and always with food. Capsules should be taken at mealtimes.
The dosage in one study was determined using the usual principle of dose conversion from animal to human. Note that fisetin constitutes a more powerful alternative to Supersmart’s
It should also be noted that inhibits the glucurono conjugation of fisetin and thus its bioavailability (by a factor of 30, according to some studies).
DHA, however, acts in synergy with fisetin to reduce bone resorption. Bioflavonoids such as pycnogenol and quercetin are mutually reinforcing and it is therefore equally appropriate to combine them.
To support fisetin’s anti-aging effects, it can also be combined with the most direct precursor of the coenzyme nicotinamide adenine dinucleotide (decreased production of which contributes irreversibly to aging and a decline in bodily functions).
Even in high doses, studies found very few fisetin supplement side effects. But that doesn’t mean that everyone should take this supplement. In fact, there’s not enough research to support pregnant or nursing mothers taking them. It’s also important to note that fisetin supplements are commonly derived from Rhus Succedanea, which is a toxic plant. And while that sounds dangerous, manufacturers understand how to remove all of the toxic substances to create a safer supplement.
Lastly, note that fisetin should also not be taken alongside Vitamin K antagonists, a widely prescribed class of anticoagulant drugs.
