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Pterostilbene Supplement
Pterostilbene Supplement
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Pterostilbene Supplement
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Pterostilbene is a highly bioavailable compound with multiple anti-aging properties.

  • Is easily transported into cells, with a much greater half-life than related dietary supplements
  • Acts via fundamental biological interactions to control gene expression and modulate enzyme activity
  • Recognized anti-inflammatory, antioxidant and immune-protective benefits
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Pterostilbene Supplement for Regulation of Gene Expression

What is Pterostilbene?

Supersmart’s pterostilbene supplement is a highly bioavailable natural dietary compound in the form of vegetarian capsules with anti-inflammatory, anti-neoplastic and antioxidant properties.

Pterostilbene (4'-hydroxy-3,5-dimethoxystilbene) comes from the same family as resveratrol.

It is actually a double methylated version, which means:

  • It has greater bioavailability — around 80% compared with only 20%
  • It is easily transported into cells and with two to four times better cellular uptake
  • It has a half-life of around seven times longer, which means it breaks down more slowly

This valuable substance has been the subject of numerous studies emphasizing its considerable benefits to human health. These studies have focused on the "trans" isomer of pterostilbene.

Pterostilbene is naturally present in blueberries but at levels much too low to provide benefits. You would need about 220 pounds of blueberries to obtain a clinically relevant amount of pterostilbene.

Pterostilbene Benefits

Pterostilbene acts via fundamental biological interactions to control gene expression and modulate enzyme activity. It has a beneficial effect on genes involved in the development of cancer, atherosclerosis, diabetes and inflammation.

Supersmart’s pterostilbene is composed entirely of PteroPure®, which is the only patented, clinically-studied form of trans-pterostilbene. Its purity is over 99%.

Given all the benefits of pterostilbene capsules, this bioactive compound is also featured in other potent antioxidant formulations, such as the anti-aging product Resveratrol Synergy, available at Supersmart. Along with pterostilbene, this contains trans-resveratrol,, polydatin, a resveratrol glucoside, and fisetin, which has a stabilizing effect. There’s also AntiOxidant Synergy,,which combines 12 natural extracts with antioxidant properties, including an extract of Japanese knotweed (Polygonum cuspidatum Sieb).

What do studies show about Pterostilbene?

So, exactly what is pterostilbene good for? Here are some of the benefits you can expect from one of the best pterostilbene supplements available:

  • The journal Apoptosis reported on a study carried out in 2012, which highlighted that pterostilbene protects against atherosclerosis (hardening of the arteries).
  • In studies on mice and human cells, pterostilbene prevented accumulation of LDL-cholesterol and protected against oxidative stress, a biological process considered a key factor in the development of cardiovascular diseases.
  • Pterostilbene’s effect on blood lipid profiles conferred much higher results compared with Ciprofibrate, a drug widely prescribed for hypercholesterolemia and which acts like pterostilbene as an agonist for nuclear receptors with PPAR- α transcription factor function. By improving blood flow, pterostilbene also normalizes diastolic and systolic blood pressure.
  • Studies show pterostilbene may improve concentration and short- and long-term memory.
  • Research shows it has a calming, de-stressing effect that relieves anxiety and nervous tension.
  • A study on mice published in 2012 in Neurobiology of Aging showed that it had a protective effect against Alzheimer's disease and age-related cognitive decline. The study's authors attributed the improvements to a reduction in the inflammation-associated factors.
  • Pterostilbene's antioxidant power enables it to neutralize free radicals associated with oxidative stress and to maintain the antioxidant status of elderly cells, according to some studies.
  • Researchers have demonstrated in rats that pterostilbene can reduce blood sugar by around 56% (making its efficacy comparable to that of some drugs that are prescribed for type II diabetes) while restoring insulin and glycated hemoglobin (HbA1c) to normal levels. It can be drawn from this that pterostilbene improves carbohydrate metabolism and its energy-regulating mechanism means it can easily be incorporated into weight loss programs.
  • For athletes and fitness enthusiasts, pterostilbene may enable a speedier recovery, as well as improved mitochondrial energy function (ATP production) and quicker production of nitric oxide via the eNOS (endothelial nitric oxide synthase) pathway, based on research.
  • Research conducted in Chicago showed pterostilbene acts as an inhibitor of the P450 enzyme, which activates pro-carcinogenic substances that can convert cigarette smoke and certain pesticides into carcinogens.
  • Other studies published in the Journal of Surgical Research, showed pterostilbene inhibits the growth of some forms of cancer (breast, colon and prostate) through modification of the cell cycle, induction of apoptosis and inhibition of proliferation of other cancer cells or metastasis.

Pterostilbene Side Effects

If you plan to take a supplement with pterostilbene, it's always best to discuss the potential side effects with your healthcare provider. Fortunately, human trials show there are minimal pterostilbene supplement side effects. It appears to be non-toxic and well-tolerated by most healthy individuals, and taking up to 250 mg per day shows no adverse side effects when compared with taking a placebo.

However, taking high doses of pterostilbene supplementation has been shown to cause an increase in LDL cholesterol. To avoid the side effects of pterostilbene supplements, it's best to stick to a trans pterostilbene dosage of 100-250 mg daily or combine the dose with Grape seed extract.

Even when taking one of the best pterostilbene supplements available, it's smart to discuss your healthcare needs with a professional. Underlying conditions and medications may put you at a greater risk of experiencing side effects. More research is needed to fully understand the risks of pterostilbene.

Dose journalière : 1 capsule
Number of doses per pack : 30
Amount per dose
pTeroPure® (Trans-Pterostilbene) 100 mg
Other ingredients : Acacia gum, rice flour.
pTeroPure®, Chromadex, USA.
Directions for use

Pterostilbene Dosage

Whether you’re looking to take pterostilbene for anti-aging benefits or to boost your overall health, you want to stick to taking 100-200 mg daily. This pterostilbene supplement dosage can be achieved by taking one or two of our capsules each day. Each pTeroPure® (Trans-Pterostilbene) capsule contains 100 mg of the highest quality pterostilbene. This bottle will last you thirty days if you take 100 mg daily.

Taking a smaller dosage in conjunction with Grape seed extract might mitigate some of the adverse effects on cholesterol when compared to taking the supplement alone.

In addition, the amount of pterostilbene you should take depends on your:

  • Age
  • Weight
  • Health conditions
  • Current medications
  • Metabolism

It's always best to start with a minimal dose to ensure you don't experience any adverse effects. You can always increase the dosage once you know your body reacts positively.

Because pterostilbene is a fat-soluble nutrient, it is best if you take your dosage with food. Also, make sure you store your supplements in a safe, dry location, away from children.

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  1. Zhang L, Zhou G, Song W, et al. Pterostilbene protects vascular endothelial cells against oxidized low-density lipoprotein-induced apoptosis in vitro and in vivo. Apoptosis. 2012;17(1):25-36. doi:10.1007/s10495-011-0653-6
  2. McCormack D, McFadden D. A review of pterostilbene antioxidant activity and disease modification. Oxid Med Cell Longev. 2013;2013:575482. doi:10.1155/2013/575482
  3. Rimando AM, Nagmani R, Feller DR, Yokoyama W. Pterostilbene, a new agonist for the peroxisome proliferator-activated receptor alpha-isoform, lowers plasma lipoproteins and cholesterol in hypercholesterolemic hamsters. J Agric Food Chem. 2005;53(9):3403-3407. doi:10.1021/jf0580364
  4. McCormack D, McFadden D. A review of pterostilbene antioxidant activity and disease modification. Oxid Med Cell Longev. 2013;2013:575482. doi:10.1155/2013/575482
  5. Al Rahim M, Rimando AM, Silistreli K, El-Alfy AT. Anxiolytic action of pterostilbene: involvement of hippocampal ERK phosphorylation. Planta Med. 2013;79(9):723-730. doi:10.1055/s-0032-1328553
  6. Dos Santos Lacerda D, Türck P, Gazzi de Lima-Seolin B, et al. Pterostilbene reduces oxidative stress, prevents hypertrophy and preserves systolic function of right ventricle in cor pulmonale model. Br J Pharmacol. 2017;174(19):3302-3314. doi:10.1111/bph.13948
  7. Tastekin B, Pelit A, Polat S, et al. Therapeutic Potential of Pterostilbene and Resveratrol on Biomechanic, Biochemical, and Histological Parameters in Streptozotocin-Induced Diabetic Rats. Evid Based Complement Alternat Med. 2018;2018:9012352. Published 2018 May 16. doi:10.1155/2018/9012352
  8. Ma Z, Yang Y, Di S, et al. Pterostilbene exerts anticancer activity on non-small-cell lung cancer via activating endoplasmic reticulum stress. Sci Rep. 2017;7(1):8091. Published 2017 Aug 14. doi:10.1038/s41598-017-08547-0
  9. Albassam AA, Frye RF. Effect of pterostilbene on in vitro drug metabolizing enzyme activity. Saudi Pharm J. 2019;27(3):406-412. doi:10.1016/j.jsps.2019.01.001
  10. Schneider JG, Alosi JA, McDonald DE, McFadden DW. Pterostilbene inhibits lung cancer through induction of apoptosis. J Surg Res. 2010;161(1):18-22. doi:10.1016/j.jss.2009.06.027
  11. Riche DM, McEwen CL, Riche KD, et al. Analysis of safety from a human clinical trial with pterostilbene. J Toxicol. 2013;2013:463595. doi:10.1155/2013/463595

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