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Welcome Shop by health concern Anti-aging Natural Rapalogs
Natural Rapalogs Supplement
Natural Rapalogs Supplement
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Natural Rapalogs
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Description

Natural Rapalogs is a natural formula designed to combat cell senescence.

  • Inhibits mTOR signaling pathways, helping to reduce excess cell replication
  • Offers the benefits of five natural inhibitors of the mTOR signaling pathway
  • May have positive effects in age-related cognitive decline
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mTOR signaling pathways

Natural Rapalogs Supplement

Our Natural Rapalogs supplement contains five natural substances that scientific findings suggest — at precise concentrations — may inhibit mTOR, potentially combatting cell senescence.

On this page, we’ll look at how eapalogs are defined, examine how the mTOR inhibitors work, how they are connected to aging and the benefits you may receive by taking a high-quality rapalogs supplement.

How do mTOR inhibitors work?

The mTOR inhibitor (mechanistic target of Rapamycin) is a threonine and serine protein kinase that was discovered over two decades ago. Since its discovery, it's become clear mTOR plays a role in governing cell proliferation and growth, making it an ideal target against conditions caused by cell proliferation.

How mTOR Inhibitors and Aging Are Connected

The acronym mTOR, which stands for mammalian target of Rapamycin, refers to an enzyme from the serine/threonine protein kinase family encoded by the mTOR gene. It is found in humans as well as worms, mice, flies and yeasts. It regulates the growth, proliferation, motility and survival of cells.

Cell senescence seems to be the driving force behind aging, both in terms of loss of cell-replication potential as well as mTOR signaling pathways inducing too much growth.

In fact, successfully inhibiting mTOR signaling pathways has been shown to affect the aging of worms, flies, yeasts and even mice — when accompanied by calorie restriction.

Benefits of Natural Rapalogs

Rapamycin is a molecule produced naturally by the mycelial bacterium Streptomyces hygroscopicus, which was discovered on Easter Island in 1975. Also known as Sirolimus, it is an immunosuppressant drug used in orthodox medicine to prevent rejection following organ transplantation.

Rapamycin inhibits the mTOR signaling pathway and studies show it may contribute to extending the lifespan of mammals, even when it’s taken in later life.

Other studies have identified potential benefits for age-related cognitive decline, specifically involving memory and learning capacity, and in particular, decreases in certain proteins that are often associated with neurodegenerative conditions. In pre-clinical trials, rapamycin analogs or "rapalogs," in particular inhibitors of the complex mTORC1, have shown measurable efficacy against certain cancers.

What are the ingredients in Natural Rapalogs?

Rapalogs’ definition is synonymous with its function: an mTOR inhibitor, or mTOR inhibitor supplement. Our natural rapalogs mTOR supplement contains the following ingredients:

Curcumin

Meriva® is a patented curcumin formulation (derived from Curcuma longa) combined with soy phospholipids to increase its bioavailability beyond that of classic standardized curcumin extracts.

This key Curcuma ingredient has emerged as a natural mTOR inhibitor.

Green tea extract standardized to 70% EGCG

Studies have confirmed the inhibitory role of certain components of green tea (Camellia sinensis) on mTORC1 and mTORC2. Specifically, a study conducted by GlaxoSmithKline in Collegeville, Pennsylvania, showed that EGCg (epigallocatechin-3-gallate) acted as a double inhibitor, both of the P13K (phosphoinositide-3-kinase) pathway and the mTOR signaling pathway.

Resveratrol

Research has established that trans resveratrol, a polyphenol compound and calorie restriction mimetic, also inhibits the mTOR signaling pathway. Studies show that this pathway is activated by oxidized LDL-cholesterol lipoproteins in smooth muscle cells. Resveratrol can, however, block the phosphorylation and activation of the P13K and mTOR pathways. This activity is independent of resveratrol's antioxidant effect and its activation of AMPK and clearly identifies a new property for resveratrol that may add to this polyphenol's overall anti-atherogenic capacities. Another study reported that at relatively high doses, resveratrol inhibits mTOR and cell senescence while contributing to cell apoptosis.

Fisetin

This flavonoid, extracted from the small tree Rhus succedanea, sends an activating signal to anti-aging gene carrier cells, ensuring DNA and neuron protection, particularly during periods of oxidative stress.

Fisetin also has a stabilizing effect on resveratrol by preventing its metabolic breakdown and therefore supports its function of inhibiting the mTOR signaling pathway.

Salicin extracted from white willow

This highly active compound extracted from white willow bark (Salix alba) gave rise to the isolation of the acetylsalicylic acid molecule (aspirin®) by the chemist Felix Hoffman.

Salicin possesses all the activity of aspirin®, including its mTOR inhibitory effect. Although not as fast-acting as aspirin®, its effect is less intrusive, and it has longer-lasting efficacy.

Additional Supplements for Aging

With its exceptional formulation, Natural Rapalogs capsules offer the benefits of five natural inhibitors of the mTOR signaling pathway. But, in addition to this potent natural complex, there are other natural anti-aging supplements available to buy at Supersmart.

Our Longevity Nutrients supplement, for example, has been formulated to provide a range of anti-aging nutrients. Similarly, the powerful AMPK Booster contains three plant extracts with active principles that reactivate a key enzyme of metabolism called AMPK. There’s also our Nicotinamide Mononucleotide supplement, an innovative formulation based on the latest advances in anti-aging medicine.

Composition
Daily dose : 3 capsules
Number of doses per pack : 30
Amount per dose
Meriva® (soy phospholipids, extracted from Curcuma longa)A 500 mg
Green tea extract standardized to 70% EGCg 340 mg
Polygonum cuspidatum extract standardized to 50% trans-resveratrol 400 mg
Rhus Succedanea extract standardized to 98% fisetin 10 mg
White willow extract standardized to 25% salicin 300 mg
Other ingredients: Acacia gum, white rice flour.
Meriva®, Indena, Italy.
Directions for use

How to Take mTOR Inhibitor Supplements

Even the most effective rapalogs won’t work properly if you don’t take them correctly. If you are taking rapalogs for aging, we recommend taking three capsules a day, always with a meal.

Note, however, that before you begin taking any supplement, you should research the side effects.

There’s also a chance Rapalogs could interact negatively with other medicines. For example, Rapalogs should not be taken if you are allergic to aspirin. There are also some conditions that could prevent you from taking this supplement. If you are taking any other prescriptions or supplements, or if you have any preexisting health conditions, you will want to discuss this supplement with your healthcare provider.

It's unclear how the rapalogs supplement may affect pregnant or breastfeeding mothers. For this reason, we recommend avoiding taking this supplement until more research is performed.

Always store your supplements in a cool, dry place away from direct sunlight to maintain potency. Also, be sure to dispose of any expired supplements, and keep them out of the reach of pets and children.

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References
  1. Zheng Y, Jiang Y. mTOR Inhibitors at a Glance. Mol Cell Pharmacol. 2015;7(2):15-20.
  2. Blagosklonny MV. Rapamycin for longevity: opinion article. Aging (Albany NY). 2019;11(19):8048-8067. doi:10.18632/aging.102355
  3. Belcaro G, Cesarone MR, Dugall M, et al. Efficacy and safety of Meriva®, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients. Altern Med Rev. 2010;15(4):337-344.
  4. Nicoletti CF, Delfino HBP, Pinhel M, et al. Impact of green tea epigallocatechin-3-gallate on HIF1-α and mTORC2 expression in obese women: anti-cancer and anti-obesity effects?. Impacto del té verde epigalocatequina-3-galato en la expresión de HF1-a y mTORC2 en mujeres obesas: ¿efectos anticancerígenos y antiobesidad?. Nutr Hosp. 2019;36(2):315-320. doi:10.20960/nh.2216
  5. Zhou J, Huo X, Botchway BOA, et al. Beneficial Effects of Resveratrol-Mediated Inhibition of the mTOR Pathway in Spinal Cord Injury. Neural Plast. 2018;2018:7513748. Published 2018 Mar 26. doi:10.1155/2018/7513748
  6. Demidenko ZN, Blagosklonny MV. At concentrations that inhibit mTOR, resveratrol suppresses cellular senescence. Cell Cycle. 2009;8(12):1901-1904. doi:10.4161/cc.8.12.8810
  7. Yousefzadeh MJ, Zhu Y, McGowan SJ, et al. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. 2018;36:18-28. doi:10.1016/j.ebiom.2018.09.015
  8. Noleto-Dias C, Ward JL, Bellisai A, Lomax C, Beale MH. Salicin-7-sulfate: A new salicinoid from willow and implications for herbal medicine. Fitoterapia. 2018;127:166-172. doi:10.1016/j.fitote.2018.02.009

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