Our Spermidine supplement is made to offer a concentrated source of spermidine from a standardized rice extract.*
With age, natural spermidine levels in the body may tend to decline.* A spermidine supplement might offer a convenient and plant-based way to help maintain your daily intake of this compound.*
Spermidine seems to have been studied for its potential role in supporting autophagy – the body’s natural process for cellular renewal.* It may also contribute to overall cellular balance and help maintain already healthy cardiovascular function as part of a balanced lifestyle.*
What is Spermidine?
Spermidine is a naturally occurring polyamine compound that seems to be found in all living organisms.* It features different amine groups and might play a role in a range of cellular processes.*
Spermidine seems to be synthesized in the body from a compound called putrescine and to act as a precursor to another polyamine known as spermine.*
Spermidine appears to get its name from its initial identification in the late 17th century.* Today, it may be recognized as a compound present in all human cells and might also naturally be found in a variety of plant-based and fermented foods.*
Possible Dietary Sources of Spermidine*
Spermidine may be found in small amounts in foods such as wheat germ, soybeans, aged cheese, and mushrooms.*
Yet, maintaining consistent intake through diet alone could be challenging, which is why supplementation might offer a reliable alternative.*
Potential Benefits of Spermidine*
With age, the body’s natural levels of spermidine may gradually lower.* Supplementing with a high-quality spermidine extract could help support optimal levels as part of a daily wellness routine.*
According to research, spermidine may:*
- Support cellular renewal through the process of autophagy – the body’s natural mechanism for recycling and renewing cell components.* With age, autophagy may tend to become less effective, and increasing dietary spermidine intake may help maintain this mechanism.*
- Potentially influence lifespan – as observed in lab studies – in certain model organisms (yeast, worms, flies, etc.) and human immune cells.*
- Help maintain already healthy cardiovascular function, including blood vessel tone and circulation, based on observational research.*
- Play a role in cellular protection by potentially supporting the body’s response to oxidative and environmental factors.*
- Contribute to balanced cellular aging by possibly limiting processes such as glycation, which may affect protein structure and function over time.*
- Have been linked to longevity in diets naturally rich in spermidine in population-based studies.*
- Provide antioxidant and neuroprotective support, with emerging studies that seem to explore its effect on cellular communication and brain health.*
WARNINGS
Do not exceed the recommended daily dose. This product is a nutritional supplement and should not be used as a substitute for a varied and balanced diet or a healthy lifestyle.
STORAGE
Store in a cool, dry place away from direct sunlight, heat, and humidity.
Keep out of reach of children.
PREGNANCY AND MEDICAL CONDITIONS
If you are pregnant, breastfeeding, or have any medical conditions, consult your healthcare provider before using this product.
SUPPLEMENT INTERACTIONS
Consult your healthcare provider before use, especially if you are taking any medications or other supplements as there may be potential interactions.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Serving size: 2 capsules
Servings per container: 30 |
Amount per serving |
Spermidine (from 300 mg of rice (Oryza sativa) germ extract standardized to 1% Spermidine) |
3 mg |
Other ingredients: vegetable capsule (hypromellose), acacia gum, white rice flour. |
Recommended amount: Take 2 vegetarian capsules per day or as directed by a healthcare practitioner.
Each vegetarian capsule contains 1.5 mg of spermidine.
Duration: 30 days.
Storage: Store in a cool, dark, and dry place.
Watch out: As with all nutritional supplements, consult a health professional before taking this supplement. Not recommended for pregnant or breastfeeding women or those with a potential health concern.*
Precautions: For adults only. Do not exceed the recommended daily dose. This product is a dietary supplement and should not be used as a substitute for a varied, balanced diet and a healthy lifestyle. Keep out of children’s reach.
- Minois, N., D. Carmona-Gutierrez, and F. Madeo. 2011. Polyamines in aging …. Aging 3 (8):716–32. doi: 10.18632/aging.100361.
- Eisenberg, Tobias, Heide Knauer, Alexandra Schauer, Sabrina Buttner, Christoph Ruckenstuhl, Didac Carmona-Gutierrez, Julia Ring, Sabrina Schroeder, Christoph Magnes, Lucia Antonacci, et al. 2009. Induction of autophagy by spermidine …. Nature Cell Biology 11 (11):1305–14. doi: 10.1038/ncb1975.
- T.J. LaRocca, R.A. Gioscia-Ryan, C.M. Hearon Jr., D.R. Seals, The autophagy enhancer spermidine …, Mech. Ageing Dev. 134 (2013) 314–320, https://doi.org/10.1016/j.mad.2013.04.004.
- J. Fan, X. Yang, S. Jia, S. Kou, Y. Yang, et al., Spermidine coupled with exercise rescues skeletal muscle … via AMPK-FOXO3a signal pathway, Oncotarget 8 (2017) 17475–17490, https://doi.org/10.18632/oncotarget.15728.
- M. Filfan, R.E. Sandu, A.D. Zavaleanu, A. GresiTa, D.G. Glavan, et al., Autophagy in aging …, Rom. J. Morphol. Embryol. 58 (2017) 27–31.
- B. Levine, G. Kroemer, Autophagy …, Cell 132 (2008) 27–42, https://doi.org/10.1016/j.cell.2007.12.018.
- A. Bhukel, F. Madeo, S.J. Sigrist, Spermidine boosts autophagy to protect from synapse aging, Autophagy 13 (2017) 444–445, https://doi.org/10.1080/15548627.2016.1265193.
- Eisenberg, Tobias, Mahmoud Abdellatif, Sabrina Schroeder, Uwe Primessnig, Slaven Stekovic, Tobias Pendl, Alexandra Harger, Julia Schipke, Andreas Zimmermann, Albrecht Schmidt, et al. 2016. … by the natural polyamine spermidine. Nature Medicine 22 (12):1428–38. doi: 10.1038/nm.4222.
- Soda, K., Y. Kano, and F. Chiba. 2012. Food polyamine … – An epidemiological study. Global Journal of Health Science 4 (6):170–8. doi: 10.5539/gjhs.v4n6p170.
- F. Madeo, T. Eisenberg, F. Pietrocola, G. Kroemer, Spermidine in health …, Science 359 (2018) 1–10, https://doi.org/10.1126/science.aan2788.
- Gugliucci A, Menini T. The polyamines spermine and spermidine protect proteins from structural and functional damage by AGE precursors: a new role for old molecules? Life Sci. 2003 Apr 25;72(23):2603-16. doi: 10.1016/s0024-3205(03)00166-8. PMID: 12672506.
- Kiechl, Stefan, Raimund Pechlaner, Peter Willeit, Marlene Notdurfter, Bernhard Paulweber, Karin Willeit, Philipp Werner, Christoph Ruckenstuhl, Bernhard Iglseder, Siegfried Weger, et al. 2018. Higher spermidine intake …: A prospective population-based study. The American Journal of Clinical Nutrition 108 (2):371–80. doi: 10.1093/ajcn/nqy102.
- T. Eisenberg, M. Abdellatif, A. Zimmermann, S. Schroeder, T. Pendl, et al., Dietary spermidine f…, Autophagy 13 (2017) 767–769, https://doi.org/10.1080/15548627.2017.1280225.