Diosmin Plus is a flavonoid supplement standardised to 80% diosmin, a natural compound with powerful venotonic properties. It is designed to naturally reduce symptoms of venous insufficiency and improve circulation throughout the body.
Its enhanced bioavailability (the diosmin is 4-10 times better absorbed than standard supplements) makes it, along with the famous VeinoMax, one of the best natural venotonics available.
Who is Diosmin Plus aimed at?
Diosmin Plus is for all those affected by any of the following:
- Venous insufficiency and circulation problems. This condition is characterised by a defect in the nervous system, specifically in the veins’ valves which enable blood to be transported back up the legs. The consequent pooling of blood produces unpleasant symptoms such as pain and a feeling of heavy, swollen legs. It subsequently leads to the formation of varicosities, varicose veins and sometimes even varicose ulcers and eczema. A number of clinical trials have confirmed the efficacy of bioflavonoids, particularly diosmin, for reducing symptoms of venous insufficiency and improving the circulation (1).
- ‘Economy class’ syndrome. Those who spend too long confined in a sitting position often develop abnormal swelling in the legs and microangiopathy. This can be prevented or reduced by taking a diosmin supplement.
- Haemorrhoids. Several clinical trials have shown that diosmin can reduce the pain and bleeding of haemorrhoids (2).
What is in Diosmin Plus?
Diosmin Plus primarily contains diosmin, a flavonoid pigment found in certain citrus fruits (3-4) and plant species of the rutaceae family.
It’s an active compound that has been used therapeutically for more than 40 years to treat chronic venous insufficiency and is recognised for its venotonic and vasotonic properties. It’s associated with strengthening blood vessel walls, increasing venous tone and normalising capillary permeability.
What makes Diosmin Plus such an exceptional venotonic?
Once ingested, it is rapidly converted into diosmetin by enzymes in the gut microflora. The diosmetin is then absorbed across the intestinal wall to be converted in the bloodstream into its more active metabolite: 3, 7-O-diglucuronide (5-6).
Unfortunately, most flavonoids – and diosmin is no exception – are not very soluble, which significantly reduces their absorption through the gastrointestinal wall (7).
To rectify this problem, Supersmart has employed three innovative, high-tech processes:
- Micronisation, ie, reducing the particle size of the active principle. This increases its rate of dissolution and that of the contact surface with the intestinal epithelium.
- The use of a buffer system which increases the conversion of diosmin into diosmetin in the gastrointestinal cavity.
- Granulation, a clustering process which promotes its circulation in blood vessels.
This approach produces a diosmin supplement which is much more absorbable than standard micronised supplements. Two studies have demonstrated that Diosmin Plus is 4-10 times more bioavailable compared with conventional micronised diosmin supplements (8-9).
How should Diosmin Plus be taken?
The most common dose for diosmin is 300mg-900mg, ie 1-3 capsules a day.
It is sometimes combined with hesperidin for treating vein problems or relieving heavy leg syndrome during and post-menopause.
Diosmin is extremely well tolerated and safe to use.
Written : Avril 2019.
- Gohel MS, Davies AH. Pharmacological treatment in patients with C4, C5 and C6 venous disease. Phlebology. 2010 Oct;25 Suppl 1:35-41.
- Annoni F, Boccasanta P, et al. [Treatment of acute symptoms of hemorrhoid disease with high-dose oral O-(beta-hydroxyethyl)-rutosides]. Minerva Med 1986;77(37):1663-1668.
- Marín, F.R.; Del Río, J.A. Selection of hybrids and edible citrus species with a high content in the diosmin
- functional compound. Modulating effect of plant growth regulators on contents. J. Agric. Food Chem. 2001,
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- Caristi, C.; Bellocco, E.; Panzera, V.; Toscano, G.; Vadalà, R.; Leuzzi, U. Flavonoids detection by HPLC-DAD-MS-MS in lemon juices from Sicilian cultivars. J. Agric. Food Chem. 2003, 51, 3528–3534.
- Patel, K.; Gadewar, M.; Tahilyani, V.; Patel, D.K. A review on pharmacological and analytical aspects of diosmetin: A concise report. Chin. J. Integr. Med. 2013, 19, 792–800.
- Silvestro, L.; Tarcomnicu, I.; Dulea, C.; Attili, N.R.; Ciuca, V.; Peru, D.; Rizea Savu, S. Confirmation of diosmetin 3-O-glucuronide as major metabolite of diosmin in humans, using micro-liquid-chromatography-mass spectrometry and ion mobility mass spectrometry. Anal. Bioanal. Chem. 2013, 405, 8295–8310
- Garner, R.C.; Garner, J.V.; Gregory, S.; Whattam, M.; Calam, A.; Leong, D. Comparison of the absorption of micronized (Daflon 500 mg) and nonmicronized 14C-diosmin tablets after oral administration to healthy volunteers by accelerator mass spectrometry and liquid scintillation counting. J. Pharm. Sci. 2002, 91, 32–40
- Russo R, Mancinelli A, Ciccone M, Terruzzi F, Pisano C, Severino L. Pharmacokinetic Profile of µSMIN Plus™, a new Micronized Diosmin Formulation, after Oral Administration in Rats. Nat Prod Commun. 2015 Sep;10(9):1569-72.
- Russo, R., Chandradhara, D., & De Tommasi, N. (2018). Comparative Bioavailability of Two Diosmin Formulations after Oral Administration to Healthy Volunteers. Molecules, 23(9), 2174. doi:10.3390/molecules23092174