Curcumin¤ Meriva® is a patented curcumin formulation (derived from Curcuma longa) combined with soy phospholipids to increase its bioavailability beyond that of classic standardised curcumin extracts. This key curcuma ingredient has emerged as a natural mTOR inhibitor and exhibits anti-tumour properties in a variety of cancer cell lines via modification of a number of oncogenic pathways.
Green tea extract standardised to 70% EGCG¤ Studies have confirmed the inhibitory role of certain components of green tea (Camellia sinensis) on mTORC1 and mTORC2. Specifically, a study conducted by GlaxoSmithKline in Collegeville, Pennsylvania, showed that EGCg (epigallocatechin-3-gallate) acted as a double inhibitor, both of the P13K (phosphoinositide-3-kinase) pathway and the mTOR signalling pathway.
Resveratrol¤ Research has established that transresveratrol, a polyphenol compound and calorie restriction mimetic, also inhibits the mTOR signalling pathway. Studies show that this pathway is activated by oxidised LDL-cholesterol lipoproteins in smooth muscle cells. Resveratrol can, however, block the phosphorylation and activation of the P13K and mTOR pathways. This activity is independent of resveratrol’s antioxidant effect and its activation of AMPK and clearly identifies a new property for resveratrol that may add to this polyphenol’s overall anti-atherogenic capacities.
Fisetin¤ This flavonoid, extracted from the small tree Rhus succedanea, sends an activating signal to anti-aging gene carrier cells, ensuring DNA and neuron protection, particularly during periods of oxidative stress.
Salicin extracted from white willow¤ This highly active compound, extracted from white willow bark (Salix alba) gave rise to the isolation of the acetylsalicylic acid molecule (aspirin®) by the chemist Felix Hoffman. It has been shown that taking a baby aspirin (81 mg) a day cuts the risk of developing cancer by at least 25%. Salicin possesses all the activity of aspirin® including its mTOR inhibitory effect. Although not as fast-acting as aspirin®, its effect is less irritating and it has longer-lasting efficacy.
With its exceptional formulation, the complex Natural Rapalogs offers the benefits of five natural inhibitors of the mTOR signalling pathway. In addition to this potent natural complex, other natural anti-ageing supplements may also be of interest. The product Longevity Nutrients, for example, has been formulated to provide a range of anti-ageing nutrients with antioxidant, anti-inflammatory and anti-infection effects. Similarly, the powerful AMPK Booster contains three plant extracts with active principles that reactivate a key enzyme of metabolism called AMPK. Discover too the supplement Nicotinamide Mononucleotide (NMN), an innovative formulation based on the latest advances in anti-ageing medicine.
|Daily dose : 3 capsules
Number of doses per pack : 30
|Amount per dose|
|Meriva® (soy phospholipids, extracted from Curcuma longa)A||500 mg|
|Green tea extract standardised to 70% EGCg||340 mg|
|Polygonum cuspidatum extract standardised to 50% trans-resveratrol||400 mg|
|Rhus Succedanea extract standardised to 98% fisetin||10 mg|
|White willow extract standardised to 25% salicin||300 mg|
| Other ingredients: microcrystalline cellulose, magnesium stearate, silicon dioxide
Meriva®, Indena, Italy.
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